Navigation Links
Japanese P2 study shows potential of combined vaccine and steroid drug in castration-resistant PCa
Date:3/15/2013

Arnhem, 11 March 2013- Multi-peptide vaccination therapy combined with the low-dose steroid drug dexamethasone shows promise in treating chemotherapy-naive castration resistant prostate cancer (CRPC) patients.

The study, which won the third prize for best abstract in oncology at the 28th European Association of Urology Congress held in Milan, Italy from 15 to 19 March, showed the promising benefit of this combination therapy in patients who are chemotherapy-naive or those not yet exposed to specific antigens.

"Results of our randomized prospective study suggest that multi-peptide vaccination therapy in combination with low dose dexamethasone has the therapeutic potential as a safe and efficient option for chemotherapy-nave CRPC patients," said lead study author Dr. Takahiro Kimura, of the Jikei University School of Medicine, Dept. of Urology, Tokyo, Japan.

Since immunotherapy does not have a strong ability to decrease tumour burden, it is considerably difficult to evaluate the full extent of a significant therapeutic effect with peptide vaccines, explained Kimura. "Taking this into consideration, the present evidence is promising," he said.

The researchers have previously developed MHC class-I restricted peptide vaccines for prostate cancer and carried out a phase 1 trial to assess safety and immunological evaluation. In the present study, Kimura and his colleagues conducted a randomized phase 2 study to evaluate the efficacy of peptide vaccine therapy for chemotherapy nave CRPC patients.

Early stage CRPC (PSA<10ng/ml) patients were randomized to two treatment groups; peptide vaccine with low dose (1mg/day) dexamethasone (Dx), while the other group were given low dose Dx alone. The patients were vaccinated subcutaneously with 3 mg of selected peptides (max. 4 kinds) six times at two weeks interval. Dx 1mg/day p.o. was started on the first day of peptide vaccination. Toxicity assessment, immunological and clinical res
'/>"/>

Contact: Ivanka Moerkerken
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Japanese P2 study shows potential of combined vaccine and steroid drug in castration resistant PCa
2. CogniFit Launches its Online Brain Training Platform in Japanese
3. 68% Fake? Japanese Dietary Products Sold on eBay
4. Japanese family members less likely than others to give CPR for cardiac arrest
5. Rising cardiovascular incidence after Japanese earthquake 2011
6. Physical, Mental Toll of Japanese Nuke Plant Meltdown Assessed
7. Japanese-American Men With Low Vitamin-D Diet Face Higher Stroke Risk
8. Study uncovers new cells in the urethra which may detect hazardous substances
9. Surgery is superior to radiotherapy in men with localized PCa, says prize-winning Swedish study
10. New study on UTIs suggests flagellin is key in stimulating bodys natural defences
11. Study shows additional role for abiraterone in blocking tumor growth in CRPC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... Thompson HealthDay Reporter THURSDAY, ... wars that break out regularly between outspoken celebrities or loudmouth ... own relationship, a new study suggests. High amounts of ... if the couple is in a long-term relationship, according to ... In turn, that friction can lead to cheating and breakups, ...
(Date:7/10/2014)... More than 200 experts on aggression, who research issues ... attend the 21st World Meeting of the International Society ... Hotel, July 15-19. , Georgia State University is hosting ... year on alternating continents. , "We are excited to ... different countries, which will help produce fresh ideas about ...
(Date:7/10/2014)... infant seemingly cured of HIV that was reported as a ... The New England Journal of Medicine last fallnow ... of not taking antiretroviral therapy without evidence of virus, according ... case. , "Certainly, this is a disappointing turn ... in the child,s care, and the HIV/AIDS research community," said ...
(Date:7/10/2014)... The benefits of medical imaging far outweigh the ... Right Way, with The Right Radiation Dose. However, overuse ... Mayo Clinic is leading a collaborative effort to ensure ... published online in the Journal of Patient Safety ... Joint Commission, the Intersociety Accreditation Commission, and the Centers ...
(Date:7/10/2014)... brain operates much the same whether active or at ... understanding of schizophrenia, bipolar disorder and other serious mental ... , In newly published research in the journal ... Center for Molecular and Behavioral Neuroscience, determined that the ... basically the same as that of a person performing ...
Breaking Medicine News(10 mins):Health News:Are You Tweeting Your Marriage Away? 2Health News:Are You Tweeting Your Marriage Away? 3Health News:Georgia State hosts national conference on aggression 2Health News:Georgia State hosts national conference on aggression 3Health News:'Mississippi Baby' now has detectable HIV, researchers find 2Health News:'Mississippi Baby' now has detectable HIV, researchers find 3Health News:Mayo Clinic calls for standardization of safe imaging protocols for children 2Health News:Working to loosen the grip of severe mental illness 2
... June 30 LifeSecure Insurance Company,(LifeSecure), a wholly-owned ... announced the executive appointment of Ron Hagen to ... sales executive with extensive knowledge of,the long term ... was,regional sales vice president, long term care sales ...
... Mesothelioma Center as a way for victims, or the ... get help,very honest advice & tailor made assistance at ... According to Americas Watchdog, "watching what happened to a ... help all Mesothelioma victims, with the best possible free ...
... in newborns undergoing painful procedures should be limited ... newborn screening test but not for intramuscular injections, ... In this double-blind, randomized controlled trial of 240 ... that "sucrose reduced overall pain in newborns when ...
... how much physical activity children need to boost their health and ... study published ahead of print in the Archives of Disease ... and only one in eight girls manage the recommended weekly amounts. ... of 113 boys and 99 girls from 54 different schools, all ...
... The cognitive strategies humans use to regulate emotions can ... a team of New York University and Rutgers University ... recent issue of the journal Nature Neuroscience , ... influence decision making. , Previous research has demonstrated ...
... 25, 2008 marks a revolutionary day in history for anybody who cares ... almost tantamount to July 4th, Independence Day, for Lung Cancer. For the ... voice, thanks to Senators Chuck Hagel, Dianne Feinstein and the tireless work ... Lung Cancer Alliance. , ...
Cached Medicine News:Health News:The Mesothelioma Victims Center Offers Victims Of Asbestos Related Cancer & Their Loved Ones The Most Comprehensive Free Service Especially For US Navy Veterans 2Health News:The Mesothelioma Victims Center Offers Victims Of Asbestos Related Cancer & Their Loved Ones The Most Comprehensive Free Service Especially For US Navy Veterans 3Health News:UK and US guidelines on kids' physical activity levels need rethinking 2Health News:NYU, Rutgers study shows how using mental strategies can alter the brain's reward circuitry 2Health News:Senators Chuck Hagel and Dianne Feinstein Make Lung Cancer Matter 2Health News:Senators Chuck Hagel and Dianne Feinstein Make Lung Cancer Matter 3Health News:Senators Chuck Hagel and Dianne Feinstein Make Lung Cancer Matter 4
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... report is available in its catalogue: ... for Advanced Drug Delivery Systems -- Focus ... STUDY OBJECTIVES ...
(Date:1/15/2014)... Jan. 15, 2014  Zafgen, Inc., a leading biopharmaceutical ... severely obese patients, today announced initial results from ... inhibitor of methionine aminopeptidase 2 (MetAP2), in patients ... genetic obesity.  These results showed improvements in body ...
(Date:1/14/2014)... FRAMINGHAM, Mass. , Jan. 14, 2014 ... a leading innovator of less invasive, miniaturized circulatory support ... failure, today announced that it expects revenues for the ... bringing expected full-year 2013 revenues to approximately $208 million. ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4
... For Pfizer, a key success factor in bringing ... the condition that the drug was designed to treat. ... shift the nomenclature for the condition from "impotence" (with ... dysfunction" (more clinical-sounding) to "ED" (casual and conversationally appropriate). ...
... At MEDRAD, Inc., community outreach is a celebrated ... Day of Caring, a company-sponsored event where employees ... volunteering in their communities. (Logo: ... 1000 MEDRAD employees will participate in the event ...
Cached Medicine Technology:Using Internal Communications to Help Build a Credible External Message Regarding New Pharmaceutical Products 2MEDRAD Employees Demonstrate Longstanding Commitment to Community 2MEDRAD Employees Demonstrate Longstanding Commitment to Community 3
Inquire...
Inquire...
... Before TOPscan Dispensers used to only have two ... process the completed job at a wholesale lab, ... The alternative was to finish the order in ... additional offices required another edger, lens inventory, more ...
Inquire...
Medicine Products: