Navigation Links
Japanese P2 study shows potential of combined vaccine and steroid drug in castration-resistant PCa
Date:3/15/2013

Arnhem, 11 March 2013- Multi-peptide vaccination therapy combined with the low-dose steroid drug dexamethasone shows promise in treating chemotherapy-naive castration resistant prostate cancer (CRPC) patients.

The study, which won the third prize for best abstract in oncology at the 28th European Association of Urology Congress held in Milan, Italy from 15 to 19 March, showed the promising benefit of this combination therapy in patients who are chemotherapy-naive or those not yet exposed to specific antigens.

"Results of our randomized prospective study suggest that multi-peptide vaccination therapy in combination with low dose dexamethasone has the therapeutic potential as a safe and efficient option for chemotherapy-nave CRPC patients," said lead study author Dr. Takahiro Kimura, of the Jikei University School of Medicine, Dept. of Urology, Tokyo, Japan.

Since immunotherapy does not have a strong ability to decrease tumour burden, it is considerably difficult to evaluate the full extent of a significant therapeutic effect with peptide vaccines, explained Kimura. "Taking this into consideration, the present evidence is promising," he said.

The researchers have previously developed MHC class-I restricted peptide vaccines for prostate cancer and carried out a phase 1 trial to assess safety and immunological evaluation. In the present study, Kimura and his colleagues conducted a randomized phase 2 study to evaluate the efficacy of peptide vaccine therapy for chemotherapy nave CRPC patients.

Early stage CRPC (PSA<10ng/ml) patients were randomized to two treatment groups; peptide vaccine with low dose (1mg/day) dexamethasone (Dx), while the other group were given low dose Dx alone. The patients were vaccinated subcutaneously with 3 mg of selected peptides (max. 4 kinds) six times at two weeks interval. Dx 1mg/day p.o. was started on the first day of peptide vaccination. Toxicity assessment, immunological and clinical res
'/>"/>

Contact: Ivanka Moerkerken
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Japanese P2 study shows potential of combined vaccine and steroid drug in castration resistant PCa
2. CogniFit Launches its Online Brain Training Platform in Japanese
3. 68% Fake? Japanese Dietary Products Sold on eBay
4. Japanese family members less likely than others to give CPR for cardiac arrest
5. Rising cardiovascular incidence after Japanese earthquake 2011
6. Physical, Mental Toll of Japanese Nuke Plant Meltdown Assessed
7. Japanese-American Men With Low Vitamin-D Diet Face Higher Stroke Risk
8. Study uncovers new cells in the urethra which may detect hazardous substances
9. Surgery is superior to radiotherapy in men with localized PCa, says prize-winning Swedish study
10. New study on UTIs suggests flagellin is key in stimulating bodys natural defences
11. Study shows additional role for abiraterone in blocking tumor growth in CRPC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... , ... August 04, 2015 , ... Statement by Paul ... the introduction of the Mental Health Reform Act of 2015 by Senators ... mental health reform a reality in America. , “This legislation and H.R. ...
(Date:8/4/2015)... ... August 04, 2015 , ... assistPoint Partners, LLC is ... oncology patient assistance programs. Through a secure web portal, assistPoint connects Life Sciences, ... enterprise level, cloud-based application and workflow solution. This provides cancer center patient advocates, ...
(Date:8/4/2015)... ... August 04, 2015 , ... Healthy ... Origins® Cognizin® is a trademark for Citicoline, a nutrient that supports memory function ... those applications which have more of a semi-solid composition. Vegetarian capsules are ...
(Date:8/4/2015)... ... August 04, 2015 , ... It’s hard ... Medical & Day Spa in Santa Barbara, CA is offering the solution by ... that permanently eliminates sweat and odor glands in the underarms. This simple and ...
(Date:8/4/2015)... ... August 04, 2015 , ... Recent studies ... a rise in binge drinking among certain populations and specific locations. ... continuing to examine trends and evidence to help facilitate health care treatment to ...
Breaking Medicine News(10 mins):Health News:MHA Applauds Introduction of Mental Health Reform Act of 2015 2Health News:MHA Applauds Introduction of Mental Health Reform Act of 2015 3Health News:assistPoint.com Web Site Launched 2Health News:Healthy Origins® Introduces Cognizin® Citicoline in a Vegetarian Capsule 2Health News:Healthy Origins® Introduces Cognizin® Citicoline in a Vegetarian Capsule 3Health News:Simple, Non-Invasive, Permanent Solution To Stop Underarm Sweating in Santa Barbara 2Health News:Simple, Non-Invasive, Permanent Solution To Stop Underarm Sweating in Santa Barbara 3Health News:DARA Responds To International Trends in Binge Drinking 2Health News:DARA Responds To International Trends in Binge Drinking 3
... University of the Rockies (UoR) has introduced a ... master,s or doctoral degree in Psychology."As the demand ... an increasing need for professionals to administer the ... provided," said Dr. Steve Kirkpatrick, Dean of the ...
... Letter to Governors Rendell, Douglas Says to Use Medicaid ... Feb. 23 In a new letter to National ... Douglas (R-VT), the Coalition to Protect Senior Care (CPSC), ... today urged the nation,s Governors to ensure new state ...
... 23 Nostrum Pharmaceuticals, LLC ("Nostrum"), a privately-held ... that it has obtained a worldwide license to ... derivatives and analogues ("Caerulomycin") for their novel indication ... Institute of Microbial Technology ("IMTECH"), Chandigarh, India, one ...
... teamed up with world famous "Hippocrates Health Institute" with ... of HHI are now able to take advantage of ... the source of what many doctors and alternative health ... health problems including obesity, skin problems, and even cancer, ...
... Star Sabrina Bryan Will Visit SchoolLEOTI, Kan., Feb. 23 ... the economy. One challenge was that the junior high gymnasium ... the students with no place to exercise indoors during the ... high managed to rally support for their dedication to health ...
... March 12, 2009 - 9:00 a.m. ET HOPKINTON, Mass., ... CALP ) will conduct a conference call discussing ... a.m. ET on Thursday, March 12. Kevin Hrusovsky, ... Financial Officer, will host the call. Management will discuss ...
Cached Medicine News:Health News:University of the Rockies Introduces Mental Health Administration Specialization for Psych Majors 2Health News:National Caregiver Coalition to National Governors Association: Establish State Task Forces to Monitor Medicaid Spending, Ascertain Funds Going to Protect Seniors 2Health News:National Caregiver Coalition to National Governors Association: Establish State Task Forces to Monitor Medicaid Spending, Ascertain Funds Going to Protect Seniors 3Health News:Nostrum Pharmaceuticals Obtains Worldwide Licensing Rights From IMTECH for Clinical Development of the Small Molecule Caerulomycin and Its Proprietary Derivatives for Their Novel Indication of Immunosuppression 2Health News:Nostrum Pharmaceuticals Obtains Worldwide Licensing Rights From IMTECH for Clinical Development of the Small Molecule Caerulomycin and Its Proprietary Derivatives for Their Novel Indication of Immunosuppression 3Health News:LuxSauna Teams With World Famous Detox Health Retreat 'Hippocrates Health Institute' 2Health News:Leoti, Kan. Junior High Finds Ways to Exercise, Wins National Health Contest 2Health News:Leoti, Kan. Junior High Finds Ways to Exercise, Wins National Health Contest 3Health News:Leoti, Kan. Junior High Finds Ways to Exercise, Wins National Health Contest 4Health News:Caliper Life Sciences' Fourth Quarter 2008 Financial Results Conference Call Notice 2
(Date:8/4/2015)... , Aug. 4, 2015 HeartWare ... innovator of less invasive, miniaturized circulatory support technologies that ... announced that its President and Chief Executive Officer, ... Canaccord Genuity 35th Annual Growth Conference at 8:30 a.m. ... being held August 12-13, 2015 at the InterContinental Boston. ...
(Date:8/4/2015)... 2015  The Pittsburgh Life Sciences Greenhouse (PLSG), the ... that one of its portfolio companies, Medrobotics Corporation, has ... Robotic System in the U.S.  ... Medrobotics," said John W. Manzetti , president and ... way since spinning out of The Robotics Institute at ...
(Date:8/4/2015)... Pharma Ltd. (the "Company") (NASDAQ: NTEC ), a ... on its proprietary Accordion Pill platform technology, today announced ... the United States of 5,025,000 of ... of $6.00 per ordinary share, before underwriting discounts and ... by the Company.  In addition, the Company has granted ...
Breaking Medicine Technology:HeartWare Presentation At The Canaccord Genuity 35th Annual Growth Conference To Be Webcast 2Pittsburgh Life Sciences Greenhouse Portfolio Client Medrobotics Receives FDA Market Clearance 2Pittsburgh Life Sciences Greenhouse Portfolio Client Medrobotics Receives FDA Market Clearance 3Intec Pharma Ltd. Announces Pricing of U.S. Initial Public Offering 2Intec Pharma Ltd. Announces Pricing of U.S. Initial Public Offering 3
All BioWhittaker Cell Culture Reagent and Buffer products are manufactured in accordance with cGMP regulations and are cell culture tested to assure compatibility. , Typical Properties, Sterility : ...
...
... sulfate is effective against gram positive and ... by interfering with bacterial protein synthesis by ... Its suggested working concentration of 50 mg/L ... cells, thereby making a gentler alternative to ...
Gentamicin Reagent Solution (10 mg/ml) liquid...
Medicine Products: