Navigation Links
Japanese P2 study shows potential of combined vaccine and steroid drug in castration resistant PCa
Date:3/15/2013

Arnhem, 11 March 2013- Multi-peptide vaccination therapy combined with the low-dose steroid drug dexamethasone shows promise in treating chemotherapy-naive castration resistant prostate cancer (CRPC) patients.

The study, which won the third prize for best abstract in oncology at the 28th European Association of Urology Congress held in Milan, Italy from 15 to 19 March, showed the promising benefit of this combination therapy in patients who are chemotherapy-naive or those not yet exposed to specific antigens.

"Results of our randomized prospective study suggest that multi-peptide vaccination therapy in combination with low dose dexamethasone has the therapeutic potential as a safe and efficient option for chemotherapy-nave CRPC patients," said lead study author Dr. Takahiro Kimura, of the Jikei University School of Medicine, Dept. of Urology, Tokyo, Japan.

Since immunotherapy does not have a strong ability to decrease tumour burden, it is considerably difficult to evaluate the full extent of a significant therapeutic effect with peptide vaccines, explained Kimura. "Taking this into consideration, the present evidence is promising," he said.

The researchers have previously developed MHC class-I restricted peptide vaccines for prostate cancer and carried out a phase 1 trial to assess safety and immunological evaluation. In the present study, Kimura and his colleagues conducted a randomized phase 2 study to evaluate the efficacy of peptide vaccine therapy for chemotherapy nave CRPC patients.

Early stage CRPC (PSA<10ng/ml) patients were randomized to two treatment groups; peptide vaccine with low dose (1mg/day) dexamethasone (Dx), while the other group were given low dose Dx alone. The patients were vaccinated subcutaneously with 3 mg of selected peptides (max. 4 kinds) six times at two weeks interval. Dx 1mg/day p.o. was started on the first day of peptide vaccination. Toxicity assessment, immunological and clinical res
'/>"/>

Contact: Ivanka Moerkerken
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. CogniFit Launches its Online Brain Training Platform in Japanese
2. 68% Fake? Japanese Dietary Products Sold on eBay
3. Japanese family members less likely than others to give CPR for cardiac arrest
4. Rising cardiovascular incidence after Japanese earthquake 2011
5. Physical, Mental Toll of Japanese Nuke Plant Meltdown Assessed
6. Japanese-American Men With Low Vitamin-D Diet Face Higher Stroke Risk
7. Study shows additional role for abiraterone in blocking tumor growth in CRPC
8. Study: 15% of Children Ages 10 - 14 Consider Using Steroids; polyDNA Recommends Muxscle for Safe Muscle Building
9. Blacks With Kidney Disease Should Watch for Blood Pressure Shifts: Study
10. Study of dragonfly prey detection at MBL wins PNAS Cozzarelli Prize
11. Study shows how vitamin E can help prevent cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... For many busy people, having their missing or damaged teeth ... from dental surgery that have traditionally been required for a ... youthful appearance. , But the dental implant experts ... Hills, Calif., can provide someone with a full mouth of ... patient’s bone has deteriorated. , Dr. Saj Jivraj and Dr. ...
(Date:11/21/2014)... 21, 2014 Even with years of experience ... learn and room for growth, participating in two recent events ... Farm’s National Convention, a networking event with the leaders of ... bringing back the latest and greatest in insurance news and ... Kirk and his team (Stacy, Anthony, Reina and Jacob) as ...
(Date:11/21/2014)... West Palm Beach, FL (PRWEB) November 21, 2014 ... Administration report issued on June 11th, 2014, ... Takata Corporation can rupture when the airbag inflates. The ... break into metal shrapnel, and the metal shards may ... anyone within the vehicle’s cabin. , According to ...
(Date:11/21/2014)... Maureen Salamon HealthDay Reporter ... Jobs requiring intellectually challenging tasks may help preserve thinking ... suggests. The researchers compared IQ scores obtained ... with their memory and reasoning scores around age 70. ... jobs appeared to retain sharper thinking even years after ...
(Date:11/21/2014)... While levels of testosterone and other reproductive hormones have ... health and quality of their relationships have a stronger ... the main sex hormone in men. But, women,s ovaries ... researchers noted. The researchers analyzed data from more ... study of women,s health. They found that women with ...
Breaking Medicine News(10 mins):Health News:Anacapa Dental Art Institute Prosthodontists Develop New Technique to Offer Younger Appearance in Just One Visit 2Health News:Anacapa Dental Art Institute Prosthodontists Develop New Technique to Offer Younger Appearance in Just One Visit 3Health News:Anacapa Dental Art Institute Prosthodontists Develop New Technique to Offer Younger Appearance in Just One Visit 4Health News:Anacapa Dental Art Institute Prosthodontists Develop New Technique to Offer Younger Appearance in Just One Visit 5Health News:Kirk Martin Insurance Agency Goes Local and National with State Farm 2Health News:Takata Airbag Recall Class Action Lawsuit Resource Released by Florida Injury Attorney 2Health News:Takata Airbag Recall Class Action Lawsuit Resource Released by Florida Injury Attorney 3Health News:Could Your Job Help Preserve Your Aging Brain? 2Health News:Could Your Job Help Preserve Your Aging Brain? 3Health News:Testosterone Plays Minor Role in Older Women's Sex Lives, Study Finds 2
... receive safer and more efficient treatment through a system ... in Glasgow. The scientists have devised a method ... nebuliser, rather than the current approach of intravenous delivery. ... quickly than existing methods and without the harmful side ...
... University School of Medicine and the Case Comprehensive ... of a highly competitive $5.4 million grant to ... adenocarcinoma. This five-year award from the National Cancer ... Network (BETRNet), which consists of multiple centers collaborating ...
... cause 18 million more cases of tuberculosis worldwide over the ... That,s the sobering scenario predicted by a new study led ... continues at current rates. Smoking raises the risk of ... physician at UCSF. Once smokers develop the disease, they are ...
... JUPITER, FL, October 10, 2011 The Scripps Research ... the National Institutes of Health (NIH) to determine how ... research could lead to potentially new therapeutic targets for ... Tellinghuisen, an assistant professor on the Florida campus of ...
... -- Men with disabilities are four times more likely ... study says. The researchers studied data collected from ... Massachusetts Behavioral Risk Factor Surveillance System, an annual health ... about 14 percent of men with disabilities said they ...
... with Restless Legs Syndrome, you may have a higher risk ... in Hypertension: Journal of the American Heart Association . ... characterized by intense, unpleasant leg sensations, and an irresistible urge ... sleep and daytime drowsiness. It affects as many as 15 ...
Cached Medicine News:Health News:Inhaler treatment for lung cancer 2Health News:Case Western Reserve receives prestigious $5.4 million grant to study esophageal cancer 2Health News:Case Western Reserve receives prestigious $5.4 million grant to study esophageal cancer 3Health News:40 million TB deaths due to smoking over next 40 years 2Health News:Scripps Florida scientist awarded $2.2 million grant to study hepatitis C 2Health News:Men With Disabilities More Vulnerable to Sexual Assault 2Health News:Restless legs syndrome may raise high blood pressure risk in middle-aged women 2
(Date:11/21/2014)... 2014  Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX ... underwritten public offering of $50,000,000 of shares of its ... The offering will consist of 49,751,244 shares of common ... share.  Lexicon has also granted the underwriters a 30-day ... common stock.  All of the shares in the offering ...
(Date:11/18/2014)... MOUNT LAUREL, N.J. , Nov. 18, 2014 ... more than 230,000 American women this year who ... Manager Certification® today announced new resources for case ... cancer—stages 4 and 5—to navigate the myriad physical, ... territory. The resources are available at no cost ...
(Date:11/18/2014)... , Nov. 18, 2014 SynCardia Systems, ... the Year Award for Small Companies presented by the ... Authority. The 11th annual Governor,s Celebration of ... Arizona . Arizona ... the awards ceremony. SynCardia was honored for its Freedom® ...
Breaking Medicine Technology:Lexicon Announces Pricing Of Common Stock Offering 2Lexicon Announces Pricing Of Common Stock Offering 3New Breast Cancer Resources: Commission For Case Manager Certification Adds Specialty Tools to Case Management Body of Knowledge Online Learning Center 2SynCardia Named Innovator of the Year by the 2014 Governor's Celebration of Innovation Awards for Its Freedom Portable Driver 2SynCardia Named Innovator of the Year by the 2014 Governor's Celebration of Innovation Awards for Its Freedom Portable Driver 3
... N.C. , July 7 The growing ... company,s need to manage rapidly changing regulatory requirements in ... anticipate an increase in medical affairs funding of more ... the minds of medical affairs executives is insufficient resources, ...
... SHANGHAI , July 7 /PRNewswire-Asia-FirstCall/ ... leading developer,manufacturer and distributor of probiotics products in China ... share repurchase program,of up to US$ 20 million ... to time over the next 12 months. The repurchases will ...
Cached Medicine Technology:Medical Affairs Budget & Staffing Remain Top Challenges Despite Increased Funding 2China-Biotics, Inc. Announces US$20 million Share Buyback Program 2China-Biotics, Inc. Announces US$20 million Share Buyback Program 3
The flexible nature of the vinyl allows the user to reach deeper into the chamber and allows for a greater comfort when working inside the glove box over a long period of time compared to any rigid s...
Compact, economical Bactron II anaerobic environment system with air lock, workspace and a 200 plate capacity incubator delivers optimum productivity in a compact space....
... an ideal first anaerobic chamber. ... smaller laboratories, it can also ... station for larger labs. All ... Bactron models are standard (excluding ...
... 400-M incorporates all the familiar and proven features ... interface with the Ruskinn patented gas mixing system.The ... (0.1% - 20% in 0.1% increments), carbon dioxide ... (0% - 10% in 1% increments) components of ...
Medicine Products: