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January/February 2012 Annals of Family Medicine
Date:1/9/2012

st critical supports, they assert, are additional practice reimbursement for time spent coordinating care and the integration of care coordinators within primary care teams. The summary includes a link to a longer policy brief published simultaneously on the AHRQ website.

Organizing Care for Complex Patients in the Patient-Centered Medical Home

By Eugene C. Rich, MD

Mathematic Policy Research, Washington, D.C.

Antidepressant Treatments Safe and Effective for Patients Regardless if They Have Comorbid Medical Conditions

Though past studies have suggested that patients with general medical conditions are less responsive to antidepressant therapy, researchers studying the effectiveness and side effects of three different antidepressant regimens on patients with comorbid medical conditions found only minimal differences in treatment response between groups. Analyzing data on 665 depressed patients with none (50 percent), one (24 percent), two (15 percent) or three or more (12 percent) treated medical conditions over 28 weeks, researchers found an almost lack of statistical difference in efficacy and tolerability outcome measures. Moreover, researchers did not find any differences in outcomes between antidepressant monotherapy using escitalopram and antidepressant combination therapies (either bupropion-SR plus escitalopram or venlafaxine-XR plus mirtazapine), regardless of the number of comorbid medical conditions the patient had. The authors conclude these findings suggest that depressed patients with or without comorbid conditions can receive safe and effective depression treatment without the risk of adverse effects or antidepressant tolerability, and no additional benefit is seen for combination antidepressant therapy versus monotherapy with selective serotonin reuptake inhibitors.

Depression Treatment in Patients With General Medical Conditions: Results from the CO-MED Trial

By David W. Morris, PhD, et al

The University o
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Contact: Angela Sharma
asharma@aafp.org
913-269-2269
American Academy of Family Physicians
Source:Eurekalert

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