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JCI table of contents: Sept. 4, 2007
Date:9/4/2007

jci.org/article.php?id=33376">https://www.the-jci.org/article.php?id=33376


PHYSIOLOGY: Too many proteins spoil the muscle

Skeletal and heart (cardiac) muscles are composed of muscle fibers that contain many myofibrils, the contractile unit of muscles. Myofibrils are, in turn, built of many repeating units known as sarcomeres. As the proteins of the sarcomere are therefore crucial for muscle contraction, their synthesis, assembly, and degradation are tightly regulated and defects in any of these result in muscle dysfunction (myopathy). Eric Olson and colleagues at the University of Texas Southwestern Medical Center, Dallas, have now shown that mice lacking two proteins, MuRF1 and MuRF3, develop skeletal muscle myopathy and hypertrophic cardiomyopathy because degradation of their sarcomere proteins by the ubiquitin proteasome system was reduced. Inhibitors of MuRF proteins have been proposed as potential therapeutics for the treatment of muscle atrophy but the evidence presented in this study indicates that care should be taken to develop agents that specifically target individual MuRFs if such an approach is not to cause adverse side effects.

TITLE: Myosin accumulation and striated muscle myopathy result from loss of muscle RING finger 1 and 3

AUTHOR CONTACT:

Eric N. Olson
University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Phone: (214) 648-1187; Fax: (214) 648-1196; E-mail: Eric.Olson@utsouthwestern.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=32827


IMMUNOLOGY: Identifying who keeps watch in the skin

New data provided by Michelle Lowes and colleagues at The Rockefeller University, New York, has provided a detailed characterization of the immune sentinel cells in the normal human skin.
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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