Navigation Links
JCI table of contents: Sept. 4, 2007
Date:9/4/2007

le.php?id=33135">https://www.the-jci.org/article.php?id=33135


PHYSIOLOGY: How to enhance muscle function

Skeletal muscle is composed of two types of muscle fiber, slow and fast, which have different capabilities — slow fibers do not tire easily and are high endurance, whereas fast fibers tire easily and are low endurance. The relative amount of each fiber type is determined by muscle usage — exercise training causes fast fibers to become slow fibers, whereas inactivity that results in muscle atrophy (for example inactivity induced by spinal cord injury and unloading caused by space flight or tail suspension) causes slow fibers to become fast fibers. Two studies in mice appearing in the November issue of the Journal of Clinical Investigation have provided insight into the molecular mechanisms that regulate muscle function. As discussed in the accompanying commentary by David Glass from Novartis Institutes for BioMedical Research, these two studies provide much fodder for researchers looking to develop new therapeutics for the treatment of skeletal muscle diseases.

Eric Olson and colleagues from the University of Texas Southwestern Medical Center, Dallas, showed that in mice, proteins known as class II HDACs repress the activity of MEF2, which is required for the expression of genes that cause muscle fibers to be slow fibers. Furthermore, in slow fibers, class II HDACs were degraded by the ubiquitin proteasome system such that slow fiber identity was maintained. In the second study, Shin'ichi Takeda and colleagues from the National Center of Neurology and Psychiatry, Tokyo, showed that in mice, one mechanism by which tail suspension causes muscle atrophy is that it alters the function of a protein known as nNOS, which leads to the activation of Foxo3a, which, in turn, upregulates the expression of various atrophy-related genes. Importantly, pharmacological inhibition of nNOS attenuated muscle atrophy in the mice.'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related medicine news :

1. Another injectable contraceptive Pill approved by FDA
2. Nearly all asthma deaths preventable
3. Ginsengs efficacy debatable
4. Implantable Contact Lens Found Safe and Effective
5. Predictable genes
6. The Beneficial Effects Of Fruits and Vegetables
7. Aloe Vera Coating For Fruits And Vegetables Preservation
8. Eat more vegetables and fruits
9. Cooked vegetables give more iron
10. Unpredictable Premature Birth
11. Vegetables decrease Tobacco Toxins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... , , , , ... , , , , ... 50m downrange from the firer and approximately 30cm from the bullet... , , ... , , , , , ... , , , , , , University of Southampton researchers, ...
(Date:7/9/2014)... School of Medicine of the University of Southern ... specific component of the immune system are completely ... infection. The discovery suggests that blocking this immune ... autoimmune and hyper-inflammatory diseases such as rheumatoid arthritis ... published online on June 23 in The ...
(Date:7/8/2014)... Department of Defense,s Defense Advanced Research Projects Agency ... to $2.5 million to develop an implantable neural ... neurons within the brain to help restore memory, ... builds on the understanding that memory is a ... the brain encode information, store it and retrieve ...
(Date:7/8/2014)... 2014 In a study published yesterday in the ... La Jolla Institute (LJI) led by Pandurangan Vijayanand, Ph.D. identify ... currently affects over 200 million people world wide. , ... be divided into small sections or ,neighborhoods., Scientists can ... primed for gene production, by looking for a marker on ...
(Date:7/8/2014)... new NPR/Robert Wood Johnson Foundation/Harvard School of Public Health ... stress in Americans, lives finds that about half of ... stressful event or experience in the past year. Nearly ... to health. , More than half of those who ... month say too many overall responsibilities and financial problems ...
Breaking Medicine News(10 mins):Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 2Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 3Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 4Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 5Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 6Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 7Health News:DARPA selects Lawrence Livermore to develop world's first neural device to restore memory 2Health News:DARPA selects Lawrence Livermore to develop world's first neural device to restore memory 3Health News:LJI develops new approach to identify genes poised to respond in asthma patients 2Health News:Poll finds health most common major stressful event in Americans' lives last year 2Health News:Poll finds health most common major stressful event in Americans' lives last year 3Health News:Poll finds health most common major stressful event in Americans' lives last year 4
... ... international events for Valentine,s weekend in Las Vegas: The USA ... the Power Pilates "Power Higher" Conference will host Pilates professionals worldwide. ... teams, Pilates professionals and thousands of spectators from around the world ...
... from the Cleveland Clinic found that the overall mortality ... rheumatic diseases was not worse than the age and ... reported in previous studies of rheumatic diseases and conditions ... study appear in the February issue of Arthritis ...
... , Jan. 27 Ms. Lorren ... issued the following statement in advance of the President,s ... more than 150 public, private, and voluntary organizations dedicated to ... viral hepatitis that afflicts more than 5 million Americans: , ...
... had brain or other central nervous system cancers, or ... public, according to an article published online January 27 ... . This study was undertaken because previous studies ... had contradictory findings, or were not population-based. E.R. ...
... from diabetes, according to a prospective study of Group ... kidney failure or blindness, the result of small vessel ... heart attack or stroke. The findings were published ... journal of the American Diabetes Association. The study was ...
... Study suggests higher cost-sharing for outpatient visits may increase ... Boosting co-pays for doctor visits and other outpatient care ... may have the unintended consequence of sharply increasing hospitalizations, ... end up inflating overall health-care spending and put vulnerable ...
Cached Medicine News:Health News:Rugby & Pilates Have a Date for Valentine's Weekend in Vegas 2Health News:Rugby & Pilates Have a Date for Valentine's Weekend in Vegas 3Health News:Rugby & Pilates Have a Date for Valentine's Weekend in Vegas 4Health News:Rugby & Pilates Have a Date for Valentine's Weekend in Vegas 5Health News:Mortality rates for pediatric rheumatology patients significantly lower than previously reported 2Health News:NVHR Issues Challenge to Administration, Congress: Don't Leave 5 Million Americans Afflicted with Chronic Viral Hepatitis Out in the Cold with Budget Freeze 2Health News:NVHR Issues Challenge to Administration, Congress: Don't Leave 5 Million Americans Afflicted with Chronic Viral Hepatitis Out in the Cold with Budget Freeze 3Health News:Severe complications of diabetes higher in depressed patients 2Health News:Raising Co-Pays for Doctor Visits Raises Seniors' Hospital Use 2Health News:Raising Co-Pays for Doctor Visits Raises Seniors' Hospital Use 3
(Date:1/15/2014)... LAVAL, Quebec , Jan. 15, 2014  Valeant Pharmaceuticals ... VRX) announced that the applicable waiting period under the ... to the previously announced tender offer by its indirect ... the outstanding shares of common stock of Solta Medical, ...
(Date:1/14/2014)... 14, 2014 HeartWare International, Inc . (NASDAQ: ... invasive, miniaturized circulatory support technologies that are revolutionizing the ... expects revenues for the fourth quarter of 2013 will ... to approximately $208 million. "Our full-year revenue ...
(Date:1/14/2014)... Jan. 14, 2014 /PRNewswire-iReach/ -- Acumed,s new SLIC Screw ... with accompanying instrumentation to place and insert the screw ... soft tissue (e.g. ligament) repair or reconstruction as it ... (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) ...
Breaking Medicine Technology:Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3
... Panasonic Healthcare Group today announced a new distribution ... for the hearing professional, which will allow licensed ... www.panasonic-hearingshop.com .  This is the first time ... for hearing care professionals to order online.    ...
... CHICAGO, Feb. 10, 2012  Zacks highlights commentary from People and ... http://photos.prnewswire.com/prnh/20101027/ZIRLOGO ) For more Voice of the ... Market Percolates, Doubters Wait They,re ... of course the troll community. They,re telling you the market ...
Cached Medicine Technology:Panasonic Reaches Distribution Agreement With The Hearing Shop 2Panasonic Reaches Distribution Agreement With The Hearing Shop 3Panasonic Reaches Distribution Agreement With The Hearing Shop 4Zacks' Voice of the People highlights opportunities with Walgreen, Occidental Petroleum and Brown & Brown 2Zacks' Voice of the People highlights opportunities with Walgreen, Occidental Petroleum and Brown & Brown 3
The BluefishRx ICD-9 is a Palm OS code lookup tool which incorporates the ICD-9 code set with the full and short code descriptions. It includes a multi keyword search tool with a dictionary of over 2...
MD Coder v 6.0 is a charge capture for the Palm OS and Pocket PC operating systems. We have integrated the feedback from hospitals and physicians. MD Coder v 6.0 comes in three versions: Physician Ba...
Preferred Health Resourses Practice Management System is called Remedy. The PDA version is Remedy for the Palm. It is a data capture program for your medical billing....
ZapICD is a reference to the complete set of ICD codes....
Medicine Products: