Navigation Links
JCI table of contents: Sept. 4, 2007
Date:9/4/2007

beta1-adrenergic receptor in the heart that protects the muscle cells of the heart from dying. The potential clinical impact of these observations is discussed in the accompanying commentary by Stefan Englehardt from the University of Würzburg, Germany.

In the study, stimulation of the beta1-adrenergic receptor, in vitro in human and mouse cells and in vivo in mice, was shown to activate a beta-arrestin signaling pathway that required the G protein–coupled receptor kinases 5 and 6 and resulted in transactivation of EGFR. Signaling downstream of EGFR activation protected the heart muscle cells from the toxic effects of chronic signals from the beta1-adrenergic receptor transmitted through Gs-dependent adenylyl cyclase activation. The latter signals are associated with heart failure and so the authors suggest that drugs that block Gs-dependent adenylyl cyclase activation but activate beta-arrestin signaling might provide a new type of therapeutic for the prevention of heart failure.

TITLE: Beta-Arrestin–mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection

AUTHOR CONTACT:

Howard A. Rockman
Duke University Medical Center, Durham, North Carolina, USA.
Phone: (919) 668-2520; Fax: (919) 668-2524; E-mail: h.rockman@duke.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=31901

ACCOMPANYING COMMENTARY

TITLE: Alternative signaling: cardiomyocyte beta1-adrenergic receptors signal through EGFRs

AUTHOR CONTACT:

Stefan Engelhardt
University of Würzburg, Würzburg, Germany..
Phone: 49-931-201-48710; Fax: 49-931-201-48123; E-mail: stefan.engelhardt@virchow.uni-wuerzburg.de.

View the PDF of this article at:

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related medicine news :

1. Another injectable contraceptive Pill approved by FDA
2. Nearly all asthma deaths preventable
3. Ginsengs efficacy debatable
4. Implantable Contact Lens Found Safe and Effective
5. Predictable genes
6. The Beneficial Effects Of Fruits and Vegetables
7. Aloe Vera Coating For Fruits And Vegetables Preservation
8. Eat more vegetables and fruits
9. Cooked vegetables give more iron
10. Unpredictable Premature Birth
11. Vegetables decrease Tobacco Toxins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... 2014 Valero Renewable Fuels Company, LLC, ... VLO), and the Ports of Indiana hosted Lt. Gov. ... at a Port Appreciation and Welcome Celebration commemorating the ... , “The opening of Valero’s ethanol facility at the ... development win for the State of Indiana,” Ellspermann said. ...
(Date:8/28/2014)... HealthDay Reporter THURSDAY, Aug. ... electrical currents through the scalp to a specific network of ... day. In a small study of healthy young adults, ... networks involved in memory. That, in turn, boosted participants, performance ... the brain stimulation. During TMS, an electromagnetic coil is ...
(Date:8/28/2014)... IL (PRWEB) August 28, 2014 Data ... Supplement shows that while most hospitals utilize a basic ... health care information technology is still a challenge. ... the August issue of Health Affairs , and ... Forum’s Health Care Data Center, as well as Chantal ...
(Date:8/28/2014)... is hurting reproduction of the endangered Devils Hole pupfish, threatening ... few as 35 individuals, new research by the University of ... that geothermal water on a small shelf near the surface ... pupfish live is heating up as a result of climate ... , The hotter water, which now reaches more than ...
(Date:8/28/2014)... 28, 2014 Dr. Paul Kovatis is being ... the U.S. military for his efforts to treat many wounded ... Warriors Foundation and several other military organizations. Dr. Kovatis’ ... in WWII. Having five members of his immediate family ... Cemetery, it’s no wonder Dr. Kovatis is so dedicated to ...
Breaking Medicine News(10 mins):Health News:Valero, Ports of Indiana Celebrate Restart of Ethanol Plant 2Health News:Valero, Ports of Indiana Celebrate Restart of Ethanol Plant 3Health News:Electrical Pulses to Scalp May Boost Memory: Study 2Health News:Electrical Pulses to Scalp May Boost Memory: Study 3Health News:AHA Data Shows Progress, Challenges on Road to Healthcare IT Adoption 2Health News:AHA Data Shows Progress, Challenges on Road to Healthcare IT Adoption 3Health News:Climate change puts endangered Devils Hole pupfish at risk of extinction 2Health News:Climate change puts endangered Devils Hole pupfish at risk of extinction 3Health News:NJ Top Docs Presents, Dr. Paul Kovatis 2
... survey reveals that 61% of Australians are not aware of the ... the Salvation Army survey, binge drinking was "worryingly high" among teenage ... 41 % of the18 to 24-year-olds confessed to take not less ... ,"What is of such concern is that people don't know ...
... New York: An investigation into the degree of consequence type ... the condition before 50 years//, led to the finding that ... say Swedish researchers. ,The status of type ... measured with the presence of biological identification in the blood ...
... well known that the output of nerve cells is the ... is still unclear about how widely separated regions of the ... complex activity. A new study by neuroscientists at the University ... Francisco (UCSF) is getting to resolve this mystery. ...
... the degree of hangover one might experience, after a night ... delved into this arena, and studied the connection between the ... by being hangover less as compared to the ones with ... a hangover, characterized by an unbearable headache, nausea, dry mouth ...
... type 1 Diabetes was admitted to the Clinical Research Center ... // Four days later the North Shore suburban girl was ... body and ready to spend a few days at the ... to do well, her insulin was reduced day by day. ...
... would benefit a lot if they were given albumin ... in London and experts in Kenya have developed this ... with malaria. ,In initial studies less ... new treatment died, researchers said. "The observation is that ...
Cached Medicine News:Health News:The need for cancer warnings on alcohol packaging 2Health News:Slow brain waves integral in coordination of complex activity 2Health News:Molecular Medicine And Diabetes 2Health News:Molecular Medicine And Diabetes 3Health News:Molecular Medicine And Diabetes 4Health News:Molecular Medicine And Diabetes 5Health News:Molecular Medicine And Diabetes 6Health News:Molecular Medicine And Diabetes 7
(Date:8/28/2014)... , Aug. 28, 2014 Levi & ... commenced in the United States District Court for the ... of investors who purchased Galectin Therapeutics Inc. ("Galectin" or ... and July 28, 2014. For more information, ... alleges that during the Class Period the Company violated ...
(Date:8/28/2014)... , August 28, 2014 According ... Research "Radiofrequency Identification (RFID) Market (Tags, Readers, Middleware, Printers ... Trends and Forecast, 2014 - 2020" the global radiofrequency ... in 2013 and is expected to grow at a ... an estimated value of USD 5.3 billion in 2020. ...
(Date:8/28/2014)... , Aug. 28, 2014 ... research report is available in its ... in Asia-Pacific Markets to 2020 - ... Need in Newly Diagnosed and Recurrent ... Glioblastoma Multiforme ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Levi & Korsinsky, LLP Reminds Investors of Class Action Against Galectin Therapeutics Inc. and Its Board of Directors and a Lead Plaintiff Deadline of September 29, 2014 -- GALT 2Radiofrequency Identification (RFID) Market in Healthcare is Expected to Reach USD 5.3 Billion Globally by 2020: Transparency Market Research 2Radiofrequency Identification (RFID) Market in Healthcare is Expected to Reach USD 5.3 Billion Globally by 2020: Transparency Market Research 3Radiofrequency Identification (RFID) Market in Healthcare is Expected to Reach USD 5.3 Billion Globally by 2020: Transparency Market Research 4Radiofrequency Identification (RFID) Market in Healthcare is Expected to Reach USD 5.3 Billion Globally by 2020: Transparency Market Research 5Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 2Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 3Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 4Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 5Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 6Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 7Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 8Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 9
The Biopro All Poly cup is a uniquely designed UHMWPE acetabular cup....
The Pe-Plus offers an additional clinical option for replacing the acetabulum....
BatCup cotyloid implant, designed for use in revision surgery, is an hemispherical metal cup, with grooves on the edges that house locking flanges, which are attached to the iliac bone by cancellous ...
The cementless acetabular shells form part of the Mallory head range of femoral and acetabular implants....
Medicine Products: