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JCI table of contents: Sept. 4, 2007
Date:9/4/2007

causes disease in mice

In a new study, Benjamin Gaston and colleagues from the University of Virginia School of Medicine, Charlottesville, have shown that chronic treatment of mice with a drug known as NAC, which is an antioxidant used commonly in the clinic, causes pulmonary arterial hypertension (in humans, pulmonary arterial hypertension leads to heart failure). This surprising observation raises questions about the long-term use of NAC in humans and provides researchers with a new mouse model of pulmonary hypertension that mimics the effects of chronic hypoxia. However, as Philip Marsden cautions in the accompanying commentary, further studies are required to determine whether chronic NAC therapy causes similar problems in humans.

TITLE: S-nitrosothiols signal hypoxia-mimetic vascular pathology

AUTHOR CONTACT:

Benjamin Gaston
University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Phone: (434) 924-1820; Fax: (434) 924-8388; E-mail: bmg3g@virginia.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=29444

ACCOMPANYING COMMENTARY

TITLE: Low-molecular-weight S-nitrosothiols and blood vessel injury

AUTHOR CONTACT:

Philip A. Marsden
St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada.
Phone: (416) 978-2441; Fax: (416) 978-8765; E-mail: p.marsden@utoronto.ca.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33136


CARDIOLOGY: The beta1-adrenergic receptor is two faced in the heart

New data generated by Howard Rockman and colleagues at Duke University Medical Center, have identified a new signaling pathway downstream of the
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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