Navigation Links
JCI table of contents: Sept. 4, 2007
Date:9/4/2007

"https://www.the-jci.org/article.php?id=33375">https://www.the-jci.org/article.php?id=33375


EDITOR'S PICK: It's a knock out: eIF4E-specific antisense oligonucleotides knock down cancer

A new study by Jeremy Graff and colleagues from Eli Lilly and Company has demonstrated the anti-cancer effect of a new therapeutic in a mouse model of human tumors and has spawned clinical trials to test the ability of this therapeutic to treat human cancers. As highlighted in the accompanying commentary by Celeste Simon and colleagues from the University of Pennsylvania, Philadelphia, if the therapeutic is as effective in clinical trials as it was in mice it will be useful for the treatment of a broad range of cancers.

The growth of many tumors is promoted by increased expression of the protein eIF4E, but no eIF4E-specific therapy has yet been developed. In this study, the intravenous administration of eIF4E-specific antisense oligonucleotides (ASOs) to mice bearing human tumors substantially inhibited tumor growth. Importantly, although these ASOs also decreased eIF4E expression in normal tissues, the function of the normal tissues analyzed was not compromised. The authors therefore suggest that tumor cells are more susceptible to decreased expression of eIF4E than normal cells, meaning that eIF4E-specific ASOs should not cause damage to normal tissues.

TITLE: Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

AUTHOR CONTACT:

Jeremy R. Graff
Eli Lilly and Company, Indianapolis, Indiana, USA.
Phone: (317) 277-0220; Fax: (317) 277-3652; E-mail: graff_jeremy@lilly.com.

View the PDF of this article at: https://www.the-jci.org/article.php?id=32044

ACCOMPANYING COMMENTARY

TITLE: Taking aim at translation f
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related medicine news :

1. Another injectable contraceptive Pill approved by FDA
2. Nearly all asthma deaths preventable
3. Ginsengs efficacy debatable
4. Implantable Contact Lens Found Safe and Effective
5. Predictable genes
6. The Beneficial Effects Of Fruits and Vegetables
7. Aloe Vera Coating For Fruits And Vegetables Preservation
8. Eat more vegetables and fruits
9. Cooked vegetables give more iron
10. Unpredictable Premature Birth
11. Vegetables decrease Tobacco Toxins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... A new white paper by The ... in the long-term care environment as well as provides ... The paper, “The Power of Person-Centeredness in Long-Term Care: ... of the patient, resident and family experience in long-term ...
(Date:1/22/2015)... 22, 2015 For over 20 years, Dr. David ... and Vista area has treated just about every type of ... circumstances. And for those same twenty-plus years, the team at ... those injuries with the best possible doctor. With the ...
(Date:1/22/2015)... 22, 2015 A study recently ... flagship journal Medicine & Science in Sports & ... may help reduce gastrointestinal (GI) problems associated with ... Participants in the double-blind, placebo-controlled study took 10 ...
(Date:1/22/2015)... IsoComforter, Inc. has introduced the most innovative and easy ... treat specific body parts and muscle groups. , IsoComforter, ... use patented cold therapy machine with the innovative IsoTube design ... injuries. IsoComforter has become the industry leader in cold ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 EBSCO Information ... (AMA) are expanding their relationship in an effort to further ... the world. While EBSCO has long made AMA journals available ... sales agent for The JAMA Network. , Long ...
Breaking Medicine News(10 mins):Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... ... accordance with the requirements of Directive 98/79/EC on in vitro diagnostic medical devices. ... Madison, WI (PRWEB) March 18, ... with the requirements of Directive 98/79/EC on in vitro diagnostic medical devices. The CE mark ...
... treatments for smoking-related diseases, , THURSDAY, March 18 ... or prevented smoking-related lung inflammation in mice, Australian ... pulmonary obstructive disease (COPD) and many other health ... researchers from the University of Melbourne focused on ...
... for losing weight , THURSDAY, March 18 (HealthDay News) -- The ... of a low-fat diet comes to the unexciting conclusion that it ... regimen had almost no effect on cholesterol levels, according to a ... of Clinical Nutrition on the Women,s Health Initiative (WHI), a ...
... CHICAGO and TALLAHASSEE, Fla. , March 18 Allscripts (Nasdaq: ... Health Record (EHR) and Practice Management solution to automate and connect clinical ... will utilize Allscripts in treating patients in the outpatient setting. , ... ...
... That Could Prevent Cancer , ... , , ... ... BLOOMINGTON, Minn. , March 18 As part ...
... , March 18 PROLOR Biotech, Inc., (OTC ... proteins, today announced that it has raised $24.4 million ... common stock, par value $0.00001 per share, to ... share, which represents an approximate 17% discount to the average ...
Cached Medicine News:Health News:Promega Maxwell 16 IVD System CE Marked to the European Union IVD Directive Delivers Combined Solution for Infectious Disease 2Health News:Blocking Protein May Stem COPD 2Health News:Low-Fat Diet Does Little to Alter Cholesterol Levels 2Health News:Low-Fat Diet Does Little to Alter Cholesterol Levels 3Health News:Tallahassee Memorial HealthCare Selects Allscripts Electronic Health Record and Practice Management for More Than 100 Providers 2Health News:Tallahassee Memorial HealthCare Selects Allscripts Electronic Health Record and Practice Management for More Than 100 Providers 3Health News:Tallahassee Memorial HealthCare Selects Allscripts Electronic Health Record and Practice Management for More Than 100 Providers 4Health News:Tallahassee Memorial HealthCare Selects Allscripts Electronic Health Record and Practice Management for More Than 100 Providers 5Health News:Tallahassee Memorial HealthCare Selects Allscripts Electronic Health Record and Practice Management for More Than 100 Providers 6Health News:Tallahassee Memorial HealthCare Selects Allscripts Electronic Health Record and Practice Management for More Than 100 Providers 7Health News:Tallahassee Memorial HealthCare Selects Allscripts Electronic Health Record and Practice Management for More Than 100 Providers 8Health News:Minnesota Organizations Join Together to Save 500 Lives 2Health News:Minnesota Organizations Join Together to Save 500 Lives 3Health News:Minnesota Organizations Join Together to Save 500 Lives 4Health News:Minnesota Organizations Join Together to Save 500 Lives 5Health News:PROLOR Biotech Announces Sale of $24.4 Million of Common Stock 2Health News:PROLOR Biotech Announces Sale of $24.4 Million of Common Stock 3Health News:PROLOR Biotech Announces Sale of $24.4 Million of Common Stock 4
(Date:1/23/2015)...  HyGreen, Inc., a leader in hand hygiene monitoring, today ... a subsidiary of Ascendis Health Limited, in ... hundreds of millions of patients around the world are ... from patient to patient via the unwashed hands of ...
(Date:1/23/2015)... 2015  iMD Companies, Inc. (ICBU) has repositioned itself as a ... grab a foothold in the hydroponic, hemp and medical marijuana ... presence in the sector, and recently partnering with the Chippewa ... and medical marijuana, iMD is committing to bring its vision ...
(Date:1/23/2015)... 23, 2015 Cord Blood America, Inc. ( www.cordblood-america.com ) ... "Company")  filed a Preliminary Proxy Statement, Schedule 14A, with the ... provides an update for shareholders detailing why a "YES" vote ... Dear Shareholders, As we reflect upon the ...
Breaking Medicine Technology:HyGreen Partners with RCA Medical in Johannesburg, South Africa 2iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4
... Combining the therapeutic benefits of controlled compression ... swelling, and pain. The anatomically designed cuff ... Cryo/Cuffs can be ordered as a single ... tube assembly and insulation disk). The Cooler ...
... designed to comfortably restrict motion of ... motion of the fingers and wrist. ... splint may be trimmed using cast ... gun. One cotton stockinet is included ...
... Cronin, Inc. is a ... Footwear, Orthopedic Softgoods, and ... Our products are of ... available in the USA ...
... Cronin, Inc. is a ... Footwear, Orthopedic Softgoods, and ... Our products are of ... available in the USA ...
Medicine Products: