Navigation Links
JCI table of contents: Oct. 19, 2009
Date:10/19/2009

EDITOR'S PICK: The protein APC slows Lou Gehrig's disease in mice

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a neurodegenerative disease that causes progressive weakness, disability, and death. Treatments are largely palliative. Using mice carrying the mutated form of the human SOD1 gene that causes inherited forms of ALS, however, Berislav Zlokovic and colleagues, at the University of Rochester Medical Center, Rochester, have now found that administration of the protein APC slows disease progression and extends survival. The authors therefore suggest that strategies designed to activate APC might be of benefit to patients with inherited, and possibly sporadic, ALS. However, in an accompanying commentary, Charles Esmon and Jonathan Glass warn that such an approach would not be without risks.

In the study, administration of both APC, whose main function is to prevent blood clotting, and APC analogs with a reduced ability to prevent blood clotting slowed disease progression in the mutant SOD1expressing mice and extended their survival, even when the compounds were administered after disease onset. Further analysis indicated that these compounds were able to access the brain and that once there, they worked by decreasing expression of the mutant SOD1 in several cell types in the brain, including the nerve cells destroyed in individuals with ALS. This study therefore indicates that APC can have a neuroprotective effect in mouse models of inherited ALS.

TITLE: Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

AUTHOR CONTACT:
Berislav V. Zlokovic
University of Rochester Medical Center, Rochester, New York, USA.
Phone: (585) 273-3132; Fax: (585) 273-3133; E-mail: berislav_zlokovic@urmc.rochester.edu.

View this article at: '/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Detecting the undetectable in prostate cancer screening
2. Drugs for Irritable Bowel Might Increase Cancer Risk
3. Not Getting Enough Fruits and Vegetables? Think Frozen! Antioxidant-rich Frozen Wild Blueberries are Convenient and Just As Nutritious As Fresh
4. Fabled vegetable lamb plant contains potential treatment for osteoporosis
5. Over 800 Lives of Domestic Violence Survivors Restored by the American Academy of Cosmetic Dentistry Charitable Foundations Give Back A Smile Program
6. Discrete Reportable Transcription to Populate the EHR/EMR With Physician Dictated Reports
7. Certain Types of Infertility Are Preventable
8. Long-Term Back Pain Not Inevitable, Study Finds
9. New Book Provides Alcoholics with Hope for Stable, Long-Term, Craving-Free Sobriety
10. OAKWORKS Clinician Massage Table Product Line Gets a Green Makeover
11. A New Jersey Anti-Poverty Charity Meets a Crisis of Need with Charitable Giving from Local Paterson, NJ Small Businesses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... The National Quality Forum’s (NQF) Board ... for a defined period that will assess the ... measures for sociodemographic factors, prior to making a ... can be socioeconomic, e.g., income, education, and occupation, ... Growing evidence shows that sociodemographic factors may ...
(Date:7/23/2014)... 23, 2014 In preparation for National ... Millennium Treatment Group is providing tips on choosing a ... society ever since man first figured out the process ... has existed since shortly thereafter. Its basis lies in ... then developing a way to combat that problem while ...
(Date:7/23/2014)... Steven Reinberg HealthDay ... -- Many obese and overweight American children and teens ... is fine, U.S. health officials reported Wednesday. "Being ... such as high blood pressure, high cholesterol and diabetes," ... the U.S. Centers for Disease Control and Prevention,s National ...
(Date:7/23/2014)... Inventor and entrepreneur Delegate Joe T. ... the gas pump – sharing his passion for technology ... at Noon. , With 24 patents granted and three ... anyone in the General Assembly since Thomas Jefferson. Inventions ... marker as seen on television, an instrument for measuring ...
(Date:7/23/2014)... WHAT: The National Institute of Biomedical Imaging and ... Investigator Symposium on July 30, 2014 on the NIH ... new investigators covering a wide breadth of NIBIB-funded research. ... Adam Cohen, Harvard, Engineering Microbial Rhodopsins as Optical Voltage ... Testing Fluorescently Labeled Probes for Nerve ...
Breaking Medicine News(10 mins):Health News:NQF Board Approves Trial Period to Test Impact of Risk Adjustment of Performance Measures for Sociodemographic Factors 2Health News:Millennium Treatment Group Offers Tips on Choosing a Reputable Treatment Center 2Health News:Millennium Treatment Group Offers Tips on Choosing a Reputable Treatment Center 3Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 2Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 3Health News:Celebrating Innovation and Invention 2
... UK, US and Canada are undermining tobacco prevention campaigns by ... public health researchers says. The paper, published in the open ... tobacco imagery should be ineligible for public funding to ensure ... goals. Earlier research shows that young people who are ...
... Aug. 23 (HealthDay News) -- Researchers say boys are ... that males have been reaching sexual maturity about 2.5 ... "The reason for earlier maturity for ... disease environments are getting more favorable for it," demographer ...
... 2011 In a joint research effort with researchers ... from scientists at The University of Pennsylvania, The University ... from the Florida campus of The Scripps Research Institute ... to rid themselves of damaged mitochondria, which are the ...
... in a new study a different approach to predict ... other similar chemicals. For many chemicals in ... to understand all of the effects on the environment ... Union enacted the REACH regulation, which places greater responsibility ...
... the University of Toronto,s psychology department show that ... Botox injections or surgery are viewed more negatively than ... facial creams and younger adults are more negative about ... suggest that despite the rapid growth of the anti-aging ...
... most frequent type of malignant brain tumor in children. Ependymoma ... hollow cavities of the brain. Therapy results of ependymoma vary ... standstill after surgery and radiotherapy, in other children the disease ... affected the tumor continues to grow and the patients often ...
Cached Medicine News:Health News:Government subsidies to the US film industry promote youth smoking, argue researchers 2Health News:Boys Mature Sexually Earlier Than Ever Before: Study 2Health News:Scripps Research scientists define cellular pathway essential to removing damaged mitochondria 2Health News:Scientists develop new approaches to predict the environmental safety of chemicals 2Health News:U of T research shows anti-aging techniques not yet viewed as acceptable 2Health News:Brain tumors found to have a 2-tier system 2
(Date:7/23/2014)... , July 23, 2014 Research and ... "Disposable Medical Gloves (Exam and Surgical) Markets Worldwide 2014" ... http://photos.prnewswire.com/prnh/20130307/600769 The purpose of this ... for Disposable Medical (Exam and Surgical) Gloves. The report ... for these products. Topics covered include product ...
(Date:7/23/2014)... 2014  Nearly 8,000 attendees will converge in ... Retail Business Conference (RBC), taking place July 23-26 at ... event encourages pharmacists to "Lead Change" in the pharmacy ... for their future. "RBC is the ... their peers and learn new ways they can lead ...
(Date:7/23/2014)... -- The management team at Columbia Laboratories, Inc. (Nasdaq: ... call on July 31, 2014, to discuss financial ... 2014.  The call details are as follows:Date: , ... numbers: , Toll free: (877) 870-4263 (U.S.), (855) ... , www.columbialabs.com , under ,Investor, or ...
Breaking Medicine Technology:Disposable Medical Gloves (Exam and Surgical) Markets Worldwide 2014 2Disposable Medical Gloves (Exam and Surgical) Markets Worldwide 2014 3Disposable Medical Gloves (Exam and Surgical) Markets Worldwide 2014 4Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 2Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 3Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 4Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 5Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 6Columbia Laboratories to Discuss Second Quarter 2014 Financial Results on July 31st Conference Call 2
... BURLINGTON, Vt ., June 4 Mach 7 Technologies ... has relocated its global headquarters from suburban Chicago to ... the company,s base for Americas, sales and professional service operations, and ... and strategic R&D functions. , ...
... June 4 /PRNewswire-Asia-FirstCall/ -- Jiangbo,Pharmaceuticals, Inc. (OTC Bulletin Board: JGBO) ... China , today,announced that the Company has received approval to list its ... , , ... will begin trading on the NASDAQ,Global Market on Tuesday, June 8, ...
Cached Medicine Technology:Mach 7 Technologies Establishes New Headquarters in Burlington, VT 2Jiangbo Pharmaceuticals, Inc. Receives Approval to List on the NASDAQ Global Market 2Jiangbo Pharmaceuticals, Inc. Receives Approval to List on the NASDAQ Global Market 3
Round handle colibri tying forceps with 5 mm titanium coated platforms. Length 100 mm....
Barraquer straight tying forceps....
Round handle curved tying forceps with 5 mm titanium coated platforms. Length 110 mm....
Colibri tying forceps with 5 mm titanium coated platforms. Length 85 mm....
Medicine Products: