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JCI table of contents: Nov. 8, 2007
Date:11/8/2007

s vitamin D production. In a new study in rats, Justin Silver and his colleagues at Hadassah Hebrew University Medical Center, Israel, have demonstrated a link between FGF23 and the parathyroid gland, an organ that is vital in calcium homeostasis.

The parathyroid glands release parathyroid hormone (PTH), a small protein that stimulates the release of calcium from bone. Researchers identified the presence of Klotho, a protein required for FGF23 to bind to tissues, on rat parathyroid glands. Furthermore, the amount of Klotho on the parathyroid increased after injection of FGF23 into rats. FGF23 injection also resulted in decreased gene expression and serum levels of PTH. Because PTH modulates serum calcium levels, and FGF23 affects vitamin D and phosphate levels, the authors suggest a mineral homeostasis feedback loop connecting the bone, kidney, and parathyroid.

TITLE: The parathyroid is a target organ for FGF23 in rats

AUTHOR CONTACT:
Justin Silver
Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Phone: 972-2-6436778; Fax: 972-2-6421234; E-mail: silver@huji.ac.il

MEDIA CONTACT:
Yael Bossem-Levi
Press Office
Hadassah Hospital, Jerusalem, Israel.
Phone: 972-2-6776220; E-mail: yael@hadassah.org.il.

View the PDF of this article at: https://www.the-jci.org/article.php?id=32409


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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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