Navigation Links
JCI table of contents: Nov. 8, 2007
Date:11/8/2007

h the carrier complexes HDL and LDL have an increased risk of developing cardiovascular disease, a class of diseases that affect the heart and or blood vessels, including atherosclerosis. In this context, high levels of HDL protect against cardiovascular disease, but the mechanisms behind this protection are poorly understood. New insight into the antiatherogenic effects of HDL is provided by a study in mice by Laurent Yvan-Charvet and colleagues at Columbia University New York.

HDL is known to promote the efflux of cholesterol from cells known as macrophage foam cells via two proteins known as ABCA1 and ABCG1. Previous studies examining the role of each of these proteins individually have produced conflicting results as to the importance of this process for the antiatherogenic effects of HDL. In this study, mice lacking both ABCA1 and ABCG1 were generated. When bone marrow from these mice was transplanted into mice susceptible to developing atherosclerosis the recipients developed atherosclerosis more rapidly than recipients of normal bone marrow or bone marrow lacking either ABCA1 or ABCG1. These data indicate that efflux of cholesterol via ABCA1 and ABCG1 is central to the antiatherogenic properties of HDL.

TITLE: Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice

AUTHOR CONTACT:
Laurent Yvan-Charvet
Columbia University College of Physicians and Surgeons, New York, New York, USA.
Phone: (212) 305-5789; Fax: (212) 305-5052; E-mail: ly2159@columbia.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33372


HEMATOLOGY: Too many red blood cells spoil the mouse

A new mouse model of Chuvash polycythemia, an inherited disease characterized by increased numbers of red blood cells, generated by Celeste Simon a
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Ranbaxy Receives Tentative Approval to Manufacture and Market Galantamine Tablets on an Exclusive Basis
2. Schering-Plough/Merck Pharmaceuticals Announce FDA Filing Acceptance of New Drug Application for Loratadine/Montelukast Tablet
3. JCI table of contents: Sept. 4, 2007
4. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
5. Actavis Launches Carvedilol Tablets in the U.S.
6. Mylan Announces Final FDA Approval for Carvedilol Tablets
7. Ranbaxy Gains Approval to Manufacture and Market Carvedilol Tablets in the U.S. Market
8. Actavis Launches Amlodipine Tablets in the U.S.
9. Implantable device designed to detect, stop seizures under study at MCG
10. Stevens Health, Technology and Society roundtable: Sept. 19
11. Fruity vegetables and fish reduce asthma and allergies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... Over 700 toys, that’s what ... That is 700 smiling little faces this holiday that ... $6000 in monetary donations was given to the various ... expenses they incur through the year. Some of the ... Child's Haven , Shrine's Children's Hospitals, Toys for Tots ...
(Date:12/24/2014)... December 24, 2014 Risperdal lawsuit ( ... mass tort litigation currently underway in Pennsylvania’s Philadelphia Court ... of December 24, 2014, court documents indicate that 1,183 ... of individuals who developed gynecomastia (male breast growth) and ... the Court indicates that this represents an increase of ...
(Date:12/24/2014)... 25, 2014 Today, UWDress.com, the famous women’s ... wedding gowns, and launched a site-wide wedding gown promotion. ... wedding gowns in a more unexpected way, the collection should ... popular in the global market, and they are available with ... are offered at discounted prices, up to 75% off; most ...
(Date:12/24/2014)... BambooIndustry.com a famous bamboo flooring company offering bamboo flooring ... announces its multiple layer bamboo panel board collection , ... , Bamboo panel is the product made from 100 ... board features high quality selective bamboo and eco-friendly adhesives ... panel consists of multiple layers of bamboo. , According ...
(Date:12/24/2014)... A new, injectable weight-loss drug has been approved by ... on Tuesday approved Saxenda (liraglutide) for adults who are ... at least one weight-related health condition, such as high ... Patients taking the drug, made by Novo Nordisk, should ... FDA noted. "Obesity is a public health concern ...
Breaking Medicine News(10 mins):Health News:AlignLife Donates Over 700 Toys This Year 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 4Health News:Buy Cheap Long Sleeve Wedding Gowns At UWDress.com 2Health News:Bamboo Flooring Company Bambooindustry.com Introduces Its Multiple Layer Bamboo Panel Board Collection 2Health News:FDA Approves New Weight-Loss Drug 2Health News:FDA Approves New Weight-Loss Drug 3
... Negative pressure wound therapy is a new innovation in treating ... for frequent and stressful dressing changes. A new study ... a wide range of applications with children, and can be ... a vacuum system which applies negative suction pressure to the ...
... Bereaved families of firefighters who lost their lives to work- ... relief at last. Ontarios new labor laws state that they ... in order to qualify for compensation due the dead workers ... identify eight types of cancer that will be presumed to ...
... Service, an agency of the New York state government has ... County Hospital as a shameful "chamber of filth, decay, ... Civil Liberties Union, the agency has filed a suit in ... the ward, where patients are subjected to overcrowded conditions, physical ...
... is recalling half-gallon packages of Galliker's Acidophilus Plus Reduced ... milk may be unsafe. It has not been shown ... the raw milk itself to determine the presence or ... is free of infectious organisms. Only products with the ...
... An oral vaccine can prevent mice from developing a brain ... will be presented at the American Academy of Neurology's ... 2007. Prion diseases, which include scrapie, mad cow disease, and ... or cure. ,The disease spreads when an animal ...
... Coast Eagles star Ben Cousins broke his silence for the first ... that he has indeed a problem of substance abuse. ... rehabilitation centre for the past months. He was being treated for ... ,He did not disclose the name of the drug ...
Cached Medicine News:Health News:Ontario Grants Fast-Track Compensation Rights for Work-Related Illnesses 2Health News:Ontario Grants Fast-Track Compensation Rights for Work-Related Illnesses 3Health News:Suit Filed Against Horrors of Psychiatric Ward in New York Hospital 2Health News:Vaccine Prevents Prion Disease in Mice 2Health News:Cousins Recovering from His Substance Abuse Problem 2
(Date:12/24/2014)... 2014   Assurex Health, a personalized medicine ... providers for behavioral health and chronic pain conditions, ... in equity financing from new and existing investors, ... and Chief Executive Officer. The financing ... Assurex Health,s GeneSight ®  products.  GeneSight,s ...
(Date:12/24/2014)... , Dec. 23, 2014 Tianyin Pharmaceutical ... that specializes in patented biopharmaceutical, modernized traditional Chinese ... (API) today announced that the Company achieved the ... Manufacturing Practice (GMP) certificate of TPI,s Qionglai Facility ... (CFDA). The public notice period is a significant ...
(Date:12/24/2014)... 23, 2014  Medical Science Liaisons play a large ... between the medical device industry and key stakeholders, the ... coming years as the device industry relies on them ... research by benchmarking firm, Best Practices, LLC, one area ... edge is by harnessing new technology to enable education. ...
Breaking Medicine Technology:Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... CellTracks® Analyzer II is ... used to enumerate fluorescently ... immunomagnetically selected and aligned. ... the CellTracks® Analyzer II, ...
... These unique Acid Fast ... sputum smear with appropriate background ... containing a positive and negative ... Kinyoun (Cat. No. 353), Ziehl-Neelsen ...
PRINCIPLE: The QC-SLIDES™ are specifically designed microscope slides intended to be part of the quality control program to monitor microbiological stains and staining techniques....
PRINCIPLE: The QC-SLIDES™ are specifically designed microscope slides intended to be part of the quality control program to monitor microbiological stains and staining techniques....
Medicine Products: