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JCI table of contents: May 24, 2010
Date:5/24/2010

ARY
TITLE: Early tumor dissemination, but late metastasis: insights into tumor dormancy

AUTHOR CONTACT:
Martin Rcken
Eberhard Karls University, Tbingen, Germany.
Phone: 49.7071.2984556; Fax: 49.7071.295450; E-mail: mrocken@med.uni-tuebingen.de.

View this article at: http://www.jci.org/articles/view/43424?key=8ad3098ffa651bbc2806


INFLAMMATION: Uric acid: an in vivo trigger of sterile inflammation

Inflammation occurs not only upon microbial infection but also in response to tissue damage under sterile conditions, an event that contributes to many diseases including acetaminophen-induced liver toxicity, the most common cause of acute liver failure in the Western world. Exactly what triggers the inflammatory response under sterile conditions in vivo has not been determined, although in vitro studies have suggested several molecular candidate triggers. Now, a team of researchers, led by Kenneth Rock, at the University of Massachusetts Medical School, Worcester, has determined that one of these candidate molecules, uric acid, is a proinflammatory molecule released from dying cells and that it acts as an important trigger of cell deathinduced inflammatory responses, such as those that model acetaminophen-induced liver toxicity, in mice. In an accompanying commentary, Yan Shi, at the University of Calgary, Edmonton, outlines the novelty of this observation and suggests that uric acid might be a good therapeutic target for the treatment of inflammation induced under sterile conditions associated with substantial cell death.

TITLE: Uric acid promotes an acute inflammatory response to sterile cell death in mice

AUTHOR CONTACT:
Kenneth L. Rock
University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Phone: 508.856.2521; Fax:
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

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