Navigation Links
JCI table of contents: May 24, 2010
Date:5/24/2010

ARY
TITLE: Early tumor dissemination, but late metastasis: insights into tumor dormancy

AUTHOR CONTACT:
Martin Rcken
Eberhard Karls University, Tbingen, Germany.
Phone: 49.7071.2984556; Fax: 49.7071.295450; E-mail: mrocken@med.uni-tuebingen.de.

View this article at: http://www.jci.org/articles/view/43424?key=8ad3098ffa651bbc2806


INFLAMMATION: Uric acid: an in vivo trigger of sterile inflammation

Inflammation occurs not only upon microbial infection but also in response to tissue damage under sterile conditions, an event that contributes to many diseases including acetaminophen-induced liver toxicity, the most common cause of acute liver failure in the Western world. Exactly what triggers the inflammatory response under sterile conditions in vivo has not been determined, although in vitro studies have suggested several molecular candidate triggers. Now, a team of researchers, led by Kenneth Rock, at the University of Massachusetts Medical School, Worcester, has determined that one of these candidate molecules, uric acid, is a proinflammatory molecule released from dying cells and that it acts as an important trigger of cell deathinduced inflammatory responses, such as those that model acetaminophen-induced liver toxicity, in mice. In an accompanying commentary, Yan Shi, at the University of Calgary, Edmonton, outlines the novelty of this observation and suggests that uric acid might be a good therapeutic target for the treatment of inflammation induced under sterile conditions associated with substantial cell death.

TITLE: Uric acid promotes an acute inflammatory response to sterile cell death in mice

AUTHOR CONTACT:
Kenneth L. Rock
University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Phone: 508.856.2521; Fax:
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Avoiding Child Obesity: Children Eat Vegetables with Author of New Picture Book, A Hungry Lion in My Tummy
2. Choir Singing May Relieve Irritable Bowel Syndrome
3. The Human Spirit is Indomitable
4. AchooAllergy.com Cools Down with Portable Air Conditioners
5. Millions Are Losing Their Hearing Unnecessarily; Noise-Induced Hearing Loss Is Always Preventable, Says HearUSA Audiologist
6. Unstable chromosome regions are the origin of yeasts brewing capacity
7. The Hastings Center Report table of contents for May/June 2010
8. Physical Therapy Online Continuing Education Courses Undergo an Inevitable Evolution
9. Disabled American Veterans Charitable Services Trust Supports OIF/OEF Veterans Battling PTSD
10. JCI online early table of contents: May 17, 2010
11. Innovative Motorized and Mobile Medical Procedure Table Developed By MTI, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... “The SWEET Act is an important step ... available and help parents who are working to reduce sugar ... approach to support public health, and we will continue to ... health of all families,” said Dr. Jane Delgado President and ... introduction of the Sugar-Sweetened Beverage Tax (SWEET) Act by Congresswoman ...
(Date:3/26/2015)... Dr. Alex Rabinovich and his San Francisco ... for Bay Area patients considering dental implants or teeth ... been a top-rated center, serving primarily San Franciscans; however, ... strong demand by others throughout Northern California. , “We ... implant facility in San Francisco,”explained Dr. Alex Rabinovich, owner ...
(Date:3/26/2015)... Springs, FL (PRWEB) March 26, 2015 ... of the nation’s leading innovative specialty pharmacies, announces ... created position of Vice President of Pharmaceutical Relations. ... fostering beneficial connections with our pharmaceuticals partners and ... relationships in support of BioPlus’ expansion. , ...
(Date:3/26/2015)... UK (PRWEB) March 26, 2015 In the ... billion as of 2013 and is set to decrease through ... by 2020; the growth is expected up to 2017 at ... is expected to be owing to the surging penetration of ... HCT, Twynsta, Micardis Plus, Valturna, Benicar HCT, and Tekamlo), a ...
(Date:3/26/2015)... Sunrise, FL (PRWEB) March 26, 2015 ... unveiled its brand-new, state-of-the-art company website: http://www.metabolicnutrition.com ... of the revamped website creates a user-friendly experience ... supplement company. , The new, enhanced Metabolic ... Comprehensive information about the company’s diverse line of ...
Breaking Medicine News(10 mins):Health News:National Alliance for Hispanic Health Statement on Introduction of SWEET Act in 114th Congress 2Health News:Bay Area Dental Implant Specialist, Dr. Alex Rabinovich Announces Regional Educational Strategy 2Health News:Bay Area Dental Implant Specialist, Dr. Alex Rabinovich Announces Regional Educational Strategy 3Health News:BioPlus Specialty Pharmacy Expands Executive Team with New Position, Naming Sharon Ferrer as Vice President of Pharmaceutical Relations 2Health News:Top 8 Developed Anti-Hypertensive Therapeutics Markets Discussed in New GBI Research Report Published at MarketPublishers.com 2Health News:Top 8 Developed Anti-Hypertensive Therapeutics Markets Discussed in New GBI Research Report Published at MarketPublishers.com 3Health News:Metabolic Nutrition Launches Sleek New Website with New Features and Enhanced Consumer Information 2
... use of alternative or complementary therapies have increased over ... using // at least one form of alternative medicine. ... yoga, hypnosis, acupuncture, chiropractic care, and high-dose vitamins. ... own survey taken in 1997 to the National Health ...
... disorder, where white blood cells attack fatty tissue surrounding nerve ... is twice as common in women as in men . ... with multiple sclerosis. Since MS causes muscle weakness and fatigue, ... of life, researchers designed an exercise program to develop ...
... days of physical inactivity, the body's efficient use of insulin ... ,Researchers conducted a study in rats and found insulin sensitivity ... stopped running for two days after a period of running ... muscle in response to insulin was found to have decreased ...
... Duchenne muscular dystrophy (DMD) with the oral steroid prednisone is ... effects of the drug . Most patients with this form ... 20s from respiratory failure or heart problems. Despite the beneficial ... side effects, which can range from weight gain to behavioral ...
... people who carry a gene that produces a higher ... increased risk for stroke.// ,Researchers reviewed medical literature ... that previous study results were observational in nature. A ... factors by looking at data on the link between ...
... coronary heart disease who follow a heart-healthy diet and ... // medications that raise HDL (high-density lipoproteins or "good" ... studied 143 patients younger than 76 with low HDL ... study followed a heart-healthy diet and lost weight. However, ...
Cached Medicine News:
(Date:3/26/2015)... Over-the-counter healthcare costs can be a ... new survey of store brand over-the-counter products aimed ... to diabetes, can offer significant savings for those ... Private Label Manufacturers Association, assembled a market basket ... essential for treatment of pre-diabetes and diabetes. These ...
(Date:3/26/2015)... 2015  Desert Valley Medical Center, named a Top ... is the first U.S. hospital to deploy the wireless ... help clinicians prevent hospital acquired pressure ulcers. ... , is a community hospital serving some higher risk ... Patient Monitor in the hospital,s emergency department enables the ...
(Date:3/26/2015)... Californie, 26 mars 2015 Finesse Solutions ... conçu pour les innovateurs, visionnaires et cadres de ... conférence d,une durée de deux jours proposée exclusivement ... dans le centre ville de San ... 2015. Il s,agira d,un forum destiné aux leaders ...
Breaking Medicine Technology:Consumers can keep over-the-counter medicine affordable by using store brands 2Desert Valley Medical Center First to Use Leaf Healthcare Patient Wearable Technology in its ED as Part of Hospital-wide Deployment 2Desert Valley Medical Center First to Use Leaf Healthcare Patient Wearable Technology in its ED as Part of Hospital-wide Deployment 3Finesse Solutions annonce l'événement Cellworld 2015 2
... Its USD520.6 million Sale to Sanofi-... -- PARIS, Nov. 1, 2010 /PRNewswire-Asia/ -- ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we need ...
... NeoStem, Inc. (NYSE Amex: NBS ) ... operations in the U.S. and China, today announced that ... (China), Inc., the Company,s wholly-owned subsidiary, will present "Building ... Therapy Industry Summit 2010 hosted by Life Technologies Corporation ...
Cached Medicine Technology:E. J. McKay Advises BMP Sunstone on Its USD520.6 million Sale to Sanofi- aventis 2E. J. McKay Advises BMP Sunstone on Its USD520.6 million Sale to Sanofi- aventis 3E. J. McKay Advises BMP Sunstone on Its USD520.6 million Sale to Sanofi- aventis 4E. J. McKay Advises BMP Sunstone on Its USD520.6 million Sale to Sanofi- aventis 5E. J. McKay Advises BMP Sunstone on Its USD520.6 million Sale to Sanofi- aventis 6E. J. McKay Advises BMP Sunstone on Its USD520.6 million Sale to Sanofi- aventis 7E. J. McKay Advises BMP Sunstone on Its USD520.6 million Sale to Sanofi- aventis 8NeoStem to Present at Cell Therapy Industry Summit to be held on November 3-5, 2010 in Carlsbad, California 2NeoStem to Present at Cell Therapy Industry Summit to be held on November 3-5, 2010 in Carlsbad, California 3
... Sun Med TruFlow™ Oxygen flowmeter with ... lifetime warranty covering calibration and manufacturing defects. ... to meet most needs. Also available with ... auxiliary power take-off and double unit configurations. ...
... TruFlow™ Oxygen flowmeter with a Lexan®inner calibrated ... calibration and manufacturing defects. A wide range ... needs. Also available with all popular inlet ... and double unit configurations. Our extra large ...
... Oxygen flowmeter with a Lexan®inner calibrated flow ... and manufacturing defects. A wide range of ... Also available with all popular inlet connections, ... double unit configurations. Our extra large knob ...
... Sun Med TruFlow™ Oxygen flowmeter with ... lifetime warranty covering calibration and manufacturing defects. ... to meet most needs. Also available with ... auxiliary power take-off and double unit configurations. ...
Medicine Products: