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JCI table of contents: May 24, 2010
Date:5/24/2010

ore of great importance for developing new anticancer therapeutics. A team of researchers, led by Jean-Pierre Abastado, at the Singapore Immunology Network, Singapore, has now provided insight into the issue by studying tumor cell dissemination in a mouse model of spontaneous melanoma (the most dangerous form of skin cancer). Martin Rcken, at Eberhard Karls University, Germany, discusses the importance of these data in an accompanying commentary.

The classical model of tumor cell dissemination is that it occurs late in tumor development, after the original tumor has grown. However, recent evidence suggests that single tumor cells spread to distant sites very early in the development of the original tumor. In the study, Abastado and colleagues found that tumor cells did spread to distant sites early during the development of the original tumor, even before it became clinically detectable. Interestingly, the disseminated tumor cells remained dormant for varying periods of time depending on the tissue to which they had spread. The reason the disseminated tumor cells remained dormant was that they were prevented from proliferating by immune cells known as CD8+ T cells. The authors therefore suggest that therapeutic approaches designed to bolster these immune responses should help prevent the outgrowth of tumor cells at distant sites and improve outcomes for individuals with early-stage cancer.

TITLE: Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma

AUTHOR CONTACT:
Jean-Pierre Abastado
Singapore Immunology Network, BMSI, A-STAR, Singapore.
Phone: 65.6407.0003; Fax: 65.6464.2057; E-mail: abastado@immunol.a-star.edu.sg.

View this article at: http://www.jci.org/articles/view/42002?key=5b3de9dbc98dcddf5d68

ACCOMPANYING COMMENT
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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