Navigation Links
JCI table of contents: May 24, 2010
Date:5/24/2010

ore of great importance for developing new anticancer therapeutics. A team of researchers, led by Jean-Pierre Abastado, at the Singapore Immunology Network, Singapore, has now provided insight into the issue by studying tumor cell dissemination in a mouse model of spontaneous melanoma (the most dangerous form of skin cancer). Martin Rcken, at Eberhard Karls University, Germany, discusses the importance of these data in an accompanying commentary.

The classical model of tumor cell dissemination is that it occurs late in tumor development, after the original tumor has grown. However, recent evidence suggests that single tumor cells spread to distant sites very early in the development of the original tumor. In the study, Abastado and colleagues found that tumor cells did spread to distant sites early during the development of the original tumor, even before it became clinically detectable. Interestingly, the disseminated tumor cells remained dormant for varying periods of time depending on the tissue to which they had spread. The reason the disseminated tumor cells remained dormant was that they were prevented from proliferating by immune cells known as CD8+ T cells. The authors therefore suggest that therapeutic approaches designed to bolster these immune responses should help prevent the outgrowth of tumor cells at distant sites and improve outcomes for individuals with early-stage cancer.

TITLE: Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma

AUTHOR CONTACT:
Jean-Pierre Abastado
Singapore Immunology Network, BMSI, A-STAR, Singapore.
Phone: 65.6407.0003; Fax: 65.6464.2057; E-mail: abastado@immunol.a-star.edu.sg.

View this article at: http://www.jci.org/articles/view/42002?key=5b3de9dbc98dcddf5d68

ACCOMPANYING COMMENT
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Avoiding Child Obesity: Children Eat Vegetables with Author of New Picture Book, A Hungry Lion in My Tummy
2. Choir Singing May Relieve Irritable Bowel Syndrome
3. The Human Spirit is Indomitable
4. AchooAllergy.com Cools Down with Portable Air Conditioners
5. Millions Are Losing Their Hearing Unnecessarily; Noise-Induced Hearing Loss Is Always Preventable, Says HearUSA Audiologist
6. Unstable chromosome regions are the origin of yeasts brewing capacity
7. The Hastings Center Report table of contents for May/June 2010
8. Physical Therapy Online Continuing Education Courses Undergo an Inevitable Evolution
9. Disabled American Veterans Charitable Services Trust Supports OIF/OEF Veterans Battling PTSD
10. JCI online early table of contents: May 17, 2010
11. Innovative Motorized and Mobile Medical Procedure Table Developed By MTI, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company ... to follow it on Facebook, Twitter, and Pinterest. The fans ... Angelweddingdress draws a lottery every week. , Moreover, the company ... 2015. Click Angelweddingdress homepage for more information. ...
(Date:1/22/2015)... January 23, 2015 AngelWeddingDress, the premier ... 2015 maternity wedding dresses. View website of ... looking for maternity wedding dresses online for a bridal ... with high quality for them. Its maternity wedding dresses ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and ... Merchandise Show to bestow a Juvent Sports Achievement award ... Arlene McKitrick. The award commemorated and congratulated McKitrick for ... She won her first amateur tournament in 1979 and ...
(Date:1/22/2015)... January 22, 2015 Thousand of GranuFlo ... Care recalled its GranuFlo and NaturaLyte dialysis concentrates continue ... in U.S. District Court, District of Massachusetts, Bernstein Liebhard ... the Court has remanded a case filed by the ...
(Date:1/22/2015)... over 20 years, Dr. David Cruz of Cruz Chiropractic Care ... just about every type of injury that can result from car ... twenty-plus years, the team at Doctors on Liens has ... doctor. With the combined breadth of experience between the ...
Breaking Medicine News(10 mins):Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2
... JOSE, Calif., May 22 VNUS(R) Medical,Technologies, Inc. (Nasdaq: ... the minimally invasive treatment of venous reflux disease, today,announced ... 12th Annual,Spring Investor Conference, to be held May 28-29, ... NY., VNUS, presentation is currently scheduled for 12:50 ...
... DURHAM, N.C. -- A new study by Duke University researchers provides ... of a cell plays a key role in disease, and the ... heart disease and cancer. , The nitric oxide system in cells ... regard to the way it controls proteins, and it is linked ...
... HHS Secretary Mike,Leavitt today announced efforts underway ... the Centers for Medicare & Medicaid Services (CMS),that ... and the quality,of medical care., "This initiative ... use of medical products on the market," Secretary ...
... study suggests threat of starvation triggers the switch , , ... suggests the body,s biological clock, which regulates sleep cycles ... can be overridden in extreme situations by an internal ... with mice and has not yet been tested among ...
... For patients undergoing kidney transplantation, treatment with the anti-rejection ... diabetes, reports a study in the July Journal of ... a robust association between sirolimus and diabetes after transplantation ... the United States," comments Dr. John S. Gill of ...
... (Amex:,ADL), ( http://www.amdl.com ), a world leader ... Jilin, China, announced today that,it has made available ... financial results conference call. The document can be ... Click on "Investor Relations",then "Recent News.", The ...
Cached Medicine News:Health News:Major 'missed' biochemical pathway emerges as important in virtually all cells 2Health News:Major 'missed' biochemical pathway emerges as important in virtually all cells 3Health News:New Efforts to Help Improve Medical Products for Patient Safety and Quality of Medical Care 2Health News:New Efforts to Help Improve Medical Products for Patient Safety and Quality of Medical Care 3Health News:New Efforts to Help Improve Medical Products for Patient Safety and Quality of Medical Care 4Health News:'Food Clock' May Override Master Sleep Clock in Times of Duress 2Health News:'Food Clock' May Override Master Sleep Clock in Times of Duress 3Health News:'Food Clock' May Override Master Sleep Clock in Times of Duress 4Health News:Anti-rejection drug may increase risk of diabetes after kidney transplant 2Health News:AMDL Teleconference Available on amdl.com at 5:00 p.m. EDT Today 2
(Date:1/23/2015)... , Jan. 23, 2015  Immune Therapeutics, Inc. today announced ... for the compounding, packaging and distributing of its naltrexone tablets. ... the United States . KRS Global ... naltrexone tablets in various strengths for individual patients in response ...
(Date:1/23/2015)... available for sale, The Armor1 Ankle Roll Guard is a ... by cushioning the ankle from an inversion or "roll." ... of any shoe type and allows the user to ... against sprains. With customers in physical therapy, podiatry, and ...
(Date:1/23/2015)... South Africa , Jan. 23, 2015   Leatt ... of personal protective equipment for all forms of sports, ... flagship Leatt-Brace® neck brace, announced today that the UISP ... federation, now requires all riders to wear a neck ...
Breaking Medicine Technology:Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3
Bipolar semi-floating pacing lead for temporary stimulation of the heart especially in emergency cases of bradycardial arrhythmias or for recording intracardiac ECGs....
VascoStim 2F are bipolar temporary pacing leads to be used in conjunction with thermodilution catheters with implemented paceport-channel....
Permanent, sutureless, epicardial pacing leads...
The HT-PB is a implantable bipolar tined permanent pacing lead for stimulation of the ventricle....
Medicine Products: