Navigation Links
JCI table of contents: May 24, 2010
Date:5/24/2010

ore of great importance for developing new anticancer therapeutics. A team of researchers, led by Jean-Pierre Abastado, at the Singapore Immunology Network, Singapore, has now provided insight into the issue by studying tumor cell dissemination in a mouse model of spontaneous melanoma (the most dangerous form of skin cancer). Martin Rcken, at Eberhard Karls University, Germany, discusses the importance of these data in an accompanying commentary.

The classical model of tumor cell dissemination is that it occurs late in tumor development, after the original tumor has grown. However, recent evidence suggests that single tumor cells spread to distant sites very early in the development of the original tumor. In the study, Abastado and colleagues found that tumor cells did spread to distant sites early during the development of the original tumor, even before it became clinically detectable. Interestingly, the disseminated tumor cells remained dormant for varying periods of time depending on the tissue to which they had spread. The reason the disseminated tumor cells remained dormant was that they were prevented from proliferating by immune cells known as CD8+ T cells. The authors therefore suggest that therapeutic approaches designed to bolster these immune responses should help prevent the outgrowth of tumor cells at distant sites and improve outcomes for individuals with early-stage cancer.

TITLE: Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma

AUTHOR CONTACT:
Jean-Pierre Abastado
Singapore Immunology Network, BMSI, A-STAR, Singapore.
Phone: 65.6407.0003; Fax: 65.6464.2057; E-mail: abastado@immunol.a-star.edu.sg.

View this article at: http://www.jci.org/articles/view/42002?key=5b3de9dbc98dcddf5d68

ACCOMPANYING COMMENT
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Avoiding Child Obesity: Children Eat Vegetables with Author of New Picture Book, A Hungry Lion in My Tummy
2. Choir Singing May Relieve Irritable Bowel Syndrome
3. The Human Spirit is Indomitable
4. AchooAllergy.com Cools Down with Portable Air Conditioners
5. Millions Are Losing Their Hearing Unnecessarily; Noise-Induced Hearing Loss Is Always Preventable, Says HearUSA Audiologist
6. Unstable chromosome regions are the origin of yeasts brewing capacity
7. The Hastings Center Report table of contents for May/June 2010
8. Physical Therapy Online Continuing Education Courses Undergo an Inevitable Evolution
9. Disabled American Veterans Charitable Services Trust Supports OIF/OEF Veterans Battling PTSD
10. JCI online early table of contents: May 17, 2010
11. Innovative Motorized and Mobile Medical Procedure Table Developed By MTI, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... With today’s levels of weight gain and obesity ... the causes of weight gain and how to lose weight ... of weight gain and treatments that will help patients lose ... by the Child Study Center at NYU Langone Medical Center ... ADHD and the soring rates of obesity later in life. ...
(Date:5/24/2013)... May 24, 2013 Today marks the ... online Itinerary Builder. , The redesigned and enhanced ... unique vacation itineraries on their computer or mobile device ... The interactive tool allows users to fill in their ... through and select their choice of vacation packages, accommodations, ...
(Date:5/24/2013)... CA (PRWEB) May 24, 2013 ... today of the latest update involving allegations that ... Zmax SR (azithromycin) can allegedly cause potentially ... Company reported on May 17, 2013* that Health ... Administration in warning that Zithromax can cause abnormal ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 Scott Ryan ... brother, Troy Tischler, lose 200 lbs. of fat in ... Tischler teach his younger brother the importance of exercising. ... diet. By sticking to these 7 rules of healthy ... loss goals can be accomplished. , 1.    Find a distraction ...
(Date:5/24/2013)... Psoriasis treatment cream has been released online for ... registered company is now offering its natural solution to ... infected skin. , Dermasis has launched its new psoriasis ... cream is designed to offer immediate relief to those ... red skin often caused by psoriasis outbreaks. This new ...
Breaking Medicine News(10 mins):Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Now Help Patients with Weight Gain Linked to Childhood ADHD Lose Weight Fast 2Health News:Create and Win the Perfect Halifax Getaway with the All-New Itinerary Builder 2Health News:2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning 2Health News:2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning 3Health News:2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning 4Health News:Dermasis Psoriasis Treatment Cream for Men and Women Released Online at HealthCareSupplementz.com 2
... , WASHINGTON, July 22 The ... in the new book, Rethinking Responsibility: Reflections on Sex ... Teen and Unplanned Pregnancy, a nonprofit, nonpartisan organization, the volume includes ... , , , ...
... NEW YORK and SAN FRANCISCO, July 22 WeissComm ... Weiss , who was recently named an "Emerging Power Player" by ... the inaugural CLIO Healthcare Awards . The awards honor creative ... , About the CLIO Healthcare Awards and Entry ...
... HOUSTON, July 22 Service Corporation International (NYSE: SCI ) ... the second quarter 2009 on Wednesday, August 5, 2009, after the market ... Thursday, August 6, 2009. Details of the conference call are as ... Service Corporation International Second Quarter 2009 Earnings Conference Call , ...
... Proteus syndrome is a complex disorder associated with ... and unregulated adipose tissue. The overgrowth seen in ... Patients with Proteus syndrome require repeated treatment for ... period. Aggressive treatment may cause severe functional and ...
... , BINGHAM FARMS, Mich., July 22 ... as the new Director of Strategic Partnerships. Terrisca comes to ... Lives Save Dollars (SLSD) initiative where she served most recently as ... with key regional, state, national and international organizations to advance the ...
... , , , ... Board: ACCP) announced today that Jeffrey B. Davis, President & CEO, ... the LifeTech Capital Group on Thursday, July 30, 2009 at 10:45 am EDT. ... Astoria Boca Beach Club in Boca Raton, Florida. , , ...
Cached Medicine News:Health News:National Leaders Examine Sex and Responsibility in New Book 2Health News:National Leaders Examine Sex and Responsibility in New Book 3Health News:WeissComm Group CEO Jim Weiss Appointed Founding Board Member and Judge of First-Ever CLIO Healthcare Awards 2Health News:WeissComm Group CEO Jim Weiss Appointed Founding Board Member and Judge of First-Ever CLIO Healthcare Awards 3Health News:Service Corporation International Announces Schedule For Its Second Quarter 2009 Earnings Release and Conference Call 2Health News:Terrisca Des Jardins, MHSA, joins my1HIE as Director of Strategic Partnerships 2Health News:Access Pharmaceuticals to Present at Jessup & Lamont 2009 Growth Stock Conference 2
(Date:5/23/2013)... Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA ) today announced ... Firm of the Year by the Tech Council of ... TCM,s 25 th Annual Tech Awards Celebration held in ... recognizes the leaders and innovators in the technology and life ... surrounding regions. "We are deeply honored to ...
(Date:5/23/2013)... , May 23, 2013 Amgen (NASDAQ: ... Annual  Healthcare Conference on Thursday, May 30, 2013, at ... beginning at 9:20 a.m. Eastern Daylight Time. Arvind ... will present at the conference. Live audio of the presentation ... www.amgen.com , under Investors. A replay of the webcast ...
(Date:5/23/2013)... May 23, 2013 Hearing health affects a man,s ... and remain socially and professionally engaged, he should address any ... message that the Better Hearing Institute (BHI) is ... National Men,s Health Week , which leads up to and ... from June 10 through June 16. To ...
Breaking Medicine Technology:Vanda Pharmaceuticals Named the 2013 Life Science Firm of the Year by the Tech Council of Maryland 2Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 2Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 3Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 4
Microporous tape sheets for covering 96-well plates, square-well or flat-bottom blocks.;...
ThermalSeal RT (2mil) is Optically Clear for Real Time PCR and easy to apply. Works for all plates....
Sealing tape, slightly stiffer than Polyolefin tape....
Sealing tape featuring 3M adhesive technology. Compatible with DMSO. Good optical quality. Minimal autofluorescence....
Medicine Products: