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JCI table of contents: May 24, 2010
Date:5/24/2010

ce in a model of diabetes. The authors therefore suggest that developing therapeutics that prevent the hypusine modification of eIF5A might be a good way to preserve pancreatic beta cell function.

In an accompanying commentary, Joachim Hauber, at Heinrich-Pette-Institute for Experimental Virology and Immunology, Germany, agrees that targeting eIF5A hypusine modification might make a good therapeutic approach and discusses how these data provide new understanding of the function of eIF5A, information that has thus far been elusive to uncover.

TITLE: The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice

AUTHOR CONTACT:
Raghavendra G. Mirmira
Indiana University School of Medicine, Indianapolis, Indiana, USA.
Phone: 317.274.4145; Fax: 317.274.4107; E-mail: rmirmira@iupui.edu.

View this article at: http://www.jci.org/articles/view/38924?key=b2bc783a7aa254cd4fbd

ACCOMPANYING COMMENTARY
TITLE: Revisiting an old acquaintance: role for eIF5A in diabetes

AUTHOR CONTACT:
Joachim Hauber
Heinrich-Pette-Institute for Experimental Virology and Immunology, Hamburg, Germany.
Phone: 49.40.48051.241; Fax: 49.40.48051.184; E-mail: joachim.hauber@hpi.uni-hamburg.de.

View this article at: http://www.jci.org/articles/view/43237?key=15814398a23209e0d2ae


ONCOLOGY: Tumor cell spread: an early event kept in check by the immune system

The major cause of death in patients with cancer is the formation of tumors at sites distant to the initial tumor. Understanding more about the processes involved in the spread and development of tumors at distant sites is theref
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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