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JCI table of contents: May 24, 2010
Date:5/24/2010

les/view/39933?key=d2c548238630efc1daa6

ACCOMPANYING ARTICLE
TITLE: A molecular classifier for predicting future graft loss in late kidney transplant biopsies

AUTHOR CONTACT:
Philip F. Halloran
Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada.
Phone: 780.407.8880; Fax: 780.407.3417; E-mail: phil.halloran@ualberta.ca.

View this article at: http://www.jci.org/articles/view/41789?key=7c600d8645775c4229a2

ACCOMPANYING COMMENTARY
TITLE: Gazing into a crystal ball to predict kidney transplant outcome

AUTHOR CONTACT:
Peter S. Heeger
Mount Sinai School of Medicine, New York, New York, USA.
Phone: 212.241.6324; Fax: 212.987.0389; E-mail: peter.heeger@mssm.edu

View this article at: http://www.jci.org/articles/view/43286?key=d11a51ae2927a3000427


EDITOR'S PICK: What is the protein modification hypusine? A therapeutic target in diabetes

Underlying all forms of diabetes is dysfunction of cells in the pancreas known as beta cells. The dysfunction is, in part, a result of inflammation mediated by soluble immune molecules known as cytokines. Greater understanding is needed of the molecular mechanisms by which beta cells respond to cytokines if protective therapeutics are to be developed. Insight into this issue has now been generated in mice by researchers, led by Raghavendra G. Mirmira, at Indiana University School of Medicine, Indianapolis, who have identified a crucial role in this response for the protein eIF5A. Importantly, both depleting eIF5A and preventing it from becoming active, by blocking its modification to contain the molecule hypusine, protected mi
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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