Navigation Links
JCI table of contents: May 22, 2008
Date:5/22/2008

hich was named dendritic cell NK lectin group receptor-1 (DNGR-1), was an endocytic receptor and that if an antibody that recognizes DNGR-1 was linked to a peptide it delivered the peptide specifically to DCs expressing CD8-alpha. CTL responses directed to the peptide were induced in mice vaccinated with the peptide-linked DNGR-1specific antibody and an adjuvant. Directing these CTL responses toward melanoma cells by linking the DNGR-1specific antibody to peptides from proteins overexpressed by a melanoma cell line eradicated melanoma in a therapeutic mouse model. Further, as expression of DNGR-1 in humans was found to be restricted to a subset of DCs with characteristics similar to mouse DCs expressing CD8-alpha, the authors suggested that targeting DCs via DNGR-1 might provide a new approach to tumor immunotherapy.

TITLE: Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

AUTHOR CONTACT:
Caetano Reis e Sousa
Cancer Research UK, London, United Kingdom.
Phone: 44-20-7269-2832; Fax: 44-20-7269-2833; E-mail: caetano@cancer.org.uk.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34584


NEUROBIOLOGY: To protect against or to promote, that is the question about the role of the cellular process autophagy in Alzheimer disease

All neurodegenerative disorders (e.g. Alzheimer disease [AD], Parkinson disease, and Huntington disease) are characterized by the presence of protein aggregates in the brain and nerve cell death. Recent data have implicated a cellular process known as autophagy (whereby cells can degrade long-lived proteins and compartments to remodel their interiors and/or survive stressful situations) in neurodegeneration, but whether it protects against or promotes neurodegeneration remains controversial. New data, generated by T
'/>"/>

Contact: Karen Honey
press_releases@thje-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine news :

1. New Survey Suggests That Consumers Are Naive to the Risk of Botox Parties and the Importance of FDA Approval for Cosmetic Injectables
2. Eat Your Vegetables - That Means You, Parents!
3. Biotel Announces Profitable Third Quarter Ended March 31, 2008
4. Mylan Launches Paroxetine Hydrochloride Extended-Release Tablets
5. FDA Approves NOVO NORDISKs NovoSeven(R) RT (Coagulation Factor VIIa [Recombinant] Room Temperature Stable) for Hemophilia Patients With Inhibitors
6. Dawning Technologies, Inc. Releases JavaLin/PDI Portable Device Interface
7. SEIU Members to Politicians: Live Up to Your Promises or We Will Hold You Accountable
8. Dr. Arnold Klein Warns of Dangers With Permanent and Longer Lasting Injectable Fillers
9. Roxane Laboratories, Inc. Announces the Launch of Acarbose Tablets
10. After divorce, stable families help minimize long-term harm to children
11. Pilot study reinforces use of portable anteroom HEPA filtration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... HIPAA Secure Now! rolled out its EHR (electronic ... vendors to now offer their customers a HIPAA security ... , HIPAA Secure Now! provides risk analysis services, ... U.S. The company assesses the risks of storing and ... and device used by the practice. , HIPAA ...
(Date:8/21/2014)... 21, 2014 Inc. magazine ranked Centurion ... 500|5000, an exclusive ranking of the nation's fastest-growing private ... the most important segment of the economy—America’s independent entrepreneurs. ... LinkedIn, Zillow, and many other well-known names gained early ... is proud to have been named to the Inc. ...
(Date:8/21/2014)... August 21, 2014 The rising numbers of ... Boynton Beach, FL. For many years, countless lives have been ... in the community a new helpline was established to provide ... Florida who are seeking to overcome their youth substance ... Boynton Beach helpline at (561) 257-4053, parents and their teens ...
(Date:8/21/2014)... August 21, 2014 Drake University’s Phi ... $10,000 to support ovarian cancer research, according to Billy ... is also the kicker for the Cleveland Browns, says ... was matched by Colleen’s Dream Foundation and will fund ... Assistant Professor in the Division of Gynecologic Oncology at ...
(Date:8/20/2014)... August 21, 2014 Top 10 ... web hosting companies and announced Bluehost ( http://www.bluehost.com/track/seohosts ... hosting companies that provide high quality PHP hosting ... Top 10 Best SEO Hosting are unbiased and ... the best information possible. During the recent years, ...
Breaking Medicine News(10 mins):Health News:HIPAA Secure Now! Ramps up EHR Partner Program, Helps Healthcare Providers Achieve Meaningful Use under Revised CMS Deadlines 2Health News:Centurion Service Group Named to Inc. Magazine's List of the Nation's Fastest-Growing Private Companies 2Health News:Centurion Service Group Named to Inc. Magazine's List of the Nation's Fastest-Growing Private Companies 3Health News:Centurion Service Group Named to Inc. Magazine's List of the Nation's Fastest-Growing Private Companies 4Health News:Troubled Teens in Boynton Beach, FL Turn to Helpline for Valuable Assistance 2Health News:Drake University’s Phi Gamma Delta (FIJI) and Colleen’s Dream Foundation Donate $10,000 to the University of Iowa’s Holden Cancer Center to Fight Ovarian Cancer 2Health News:Drake University’s Phi Gamma Delta (FIJI) and Colleen’s Dream Foundation Donate $10,000 to the University of Iowa’s Holden Cancer Center to Fight Ovarian Cancer 3Health News:New Reviews Of Cheap PHP Hosting Companies Unveiled By Top 10 Best SEO Hosting 2
... Bethesda, MD (November 1, 2007) Diabetes is a very ... the U.S. and it is estimated an additional 54 million ... blood glucose levels are higher than normal but not high ... is important to determine whether glucose and insulin levels are ...
... Nov. 1 NuVasive, Inc. (Nasdaq:,NUVA), a medical device ... for the spine, announced today,that Alex Lukianov, Chairman and ... Investor Conference 2007 at the San Diego Marriott,Del Mar ... 2007 at 9:30 a.m.,PT. A live Web cast ...
... See their First Birthday, LOS ANGELES, Nov. 1 On ... all babies -- those born healthy,those who need help to thrive ... infants die before their first birthday each year -- more,than 5,000 ... Vicente Perez, Jr. is just one of those., He was ...
... Reps. Shelley Moore Capito and Tom Allen Express ... Nov. 1 Warning that cuts to,seniors, Medicare ... quality of,care and quality of life of America,s ... care, a broad array of clinician and,caregiver groups ...
... Mayo Clinic study of a drug that has shown promise ... drug may also be effective in treating breast cancer, in ... was done in mouse models, is featured on the cover ... National Cancer Institute reports that of 240,510 breast cancer diagnoses ...
... slowly to save their lives can be an invasive ... to the November issue of Journal of Clinical Nursing. ... Dublin, has called for clinical and legal guidelines to ... and highlighted the need for better communication about do ...
Cached Medicine News:Health News:Increased glucose level is a strong risk factor for colorectal cancer 2Health News:Increased glucose level is a strong risk factor for colorectal cancer 3Health News:NuVasive to Present at BIOCOM Investor Conference 2007 2Health News:NuVasive to Present at BIOCOM Investor Conference 2007 3Health News:March of Dimes Honors Babies on 'El Dia de Todos los Santos' 2Health News:Coalition of Caregivers Warns Congress of Danger to Oldest U.S. Seniors if Medicare Slashed 2Health News:Coalition of Caregivers Warns Congress of Danger to Oldest U.S. Seniors if Medicare Slashed 3Health News:Coalition of Caregivers Warns Congress of Danger to Oldest U.S. Seniors if Medicare Slashed 4Health News:Mayo Clinic study shows drug could effectively treat, prevent the spread of breast cancer 2Health News:Mayo Clinic study shows drug could effectively treat, prevent the spread of breast cancer 3Health News:Token resuscitation attempts on hopelessly ill patients prolong suffering 2Health News:Token resuscitation attempts on hopelessly ill patients prolong suffering 3
(Date:8/20/2014)... 20, 2014 Research and Markets ... "Global Biosimilars/Follow-on-Biologics Market (Technology, Types, Applications, Services and ... report to their offering. A ... and geography) - Size, Share, Global Trends, Company ... and Forecast, 2013 - 2020", suggests that the ...
(Date:8/20/2014)... ALBANY, New York , August 20, 2014 /PRNewswire/ ... published a new market report titled "Monochloroacetic Acid (MCA) ... Other Applications - Global Industry Analysis, Size, Share, Growth, ... acid market was valued at USD 817.1 million in ... by 2020, growing at a CAGR of 3.6% during ...
(Date:8/20/2014)... Research and Markets has ... Wound Care and Closure Market (Types, Applications, End ... Company Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, ... to their offering. The new ... market (types, applications, end user and geography) - ...
Breaking Medicine Technology:Global Biosimilars/Follow-on-Biologics Market (Technology, Types, Applications, Services and Geography) - Research Report, 2013 - 2020 2Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 2Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 3Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 4Global Advanced Wound Care and Closure Market (Types, Applications, End User and Geography) - Forecast to 2020 2
... MINNETONKA, Minn. , July 14 American ... provider of world-class devices and therapies for both male and ... study on their market leading MiniArc Single-Incision Sling System for ... MiniArc efficacy rates for negative cough stress test (CST) and ...
... and TULSA, Okla. , July 14 ... strategic alliance to increase the availability of important new ... These tests and the GeneMedRx medication management software can ... personalize their prescribing practices in order to prevent adverse ...
Cached Medicine Technology:12-Month Study Reports 90% Success Rate for AMS' MiniArc Single-Incision Sling 212-Month Study Reports 90% Success Rate for AMS' MiniArc Single-Incision Sling 3Helix Bioscience Appointed DNA Drug Sensitivity Testing Distributor for Genelex Corporation 2
The Sutura family of products is designed to allow interventionalists to perform vessel closure from 6F up to 24F. It's elegant design allows one-handed use through sheath, routinely eliminating need...
The Closer vascular closure device is a suture mediated closure system. It has a sheath-like profile and easy positioning. It has an innovative design which involves the needles outside the artery an...
Spyglass angiography catheters, combined with St. Jude Medical hemostasis introducers and GuideRight guidewires, offer a safe and effective diagnostic angiography system....
Jography angiographic catheter has a new material combination, a patented angled weld, a flat wire braid design with a XXL lumen. It also has an atraumatic soft tip....
Medicine Products: