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JCI table of contents: May 22, 2008
Date:5/22/2008

increased blood vessel permeability in the retina of individuals with diabetic retinopathy. In the study, injection of vasoinhibins into the eye was found to block increases in blood vessel permeability in the eye of diabetic rats and to block increases in blood vessel permeability in the eye of normal rats injected (into the eye) with either VEGF or the fluid from the eye of an individual with diabetic retinopathy. Mechanistically the vasoinhibins were shown to work by activating a protein known as PP2A, which, in turn, inactivated a protein known as eNOS.

TITLE: Vasoinhibins prevent retinal vasopermeability associated with diabetic retinopathy in rats via protein phosphatase 2Adependent eNOS inactivation

AUTHOR CONTACT:
Carmen Clapp
Universidad Nacional Autnoma de Mxico, Quertaro, Mexico.
Phone: (52-442) 238-1028; Fax: (52-442) 238-1005; E-mail: clapp@servidor.unam.mx.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34508


IMMUNOLOGY: A new target for tumor immunotherapy on dendritic cells?

Many researchers are interested in developing approaches to induce antitumor immune responses carried out by immune cells known as CTLs. In mice, one way to do this is to target tumor proteins to a subset of immune cells known as dendritic cells (DCs) that express the protein CD8-alpha. This is because DCs expressing CD8-alpha are able to efficiently direct CTLs to attack any proteins that are targeted to them. A new way to target tumor proteins to DCs expressing CD8-alpha has been uncovered by Caetano Reis e Sousa and colleagues, at Cancer Research UK, United Kingdom, who have identified a molecule whose expression is restricted in mice to DCs expressing CD8-alpha and another subset of DC known as plasmacytoid DCs.

Functional studies indicated that the molecule, w
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Contact: Karen Honey
press_releases@thje-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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