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JCI table of contents: May 22, 2008
Date:5/22/2008

>Phone: (212) 746-2070; Fax: (212) 746-2286; E-mail: srafii@med.cornell.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34401

ACCOMPANYING COMMENTARY
TITLE: Is CD133 a marker of metastatic colon cancer stem cells?

AUTHOR CONTACT:
Mina J. Bissell
Lawrence Berkeley National Laboratory, Berkeley, California, USA.
Phone: (510) 486-4365; Fax: (510) 486-5586; E-mail: MJBissell@lbl.gov.

Mark A. LaBarge
Lawrence Berkeley National Laboratory, Berkeley, California, USA.
Phone: (510) 486-4365; Fax: (510) 486-5586; E-mail: MALabarge@lbl.gov.

View the PDF of this article at: https://www.the-jci.org/article.php?id=36046


EDITOR'S PICK: Its not an AKT: genetic variation affects brain region dysfunctional in schizophrenia

New data, generated by Daniel Weinberger and colleagues, at the National Institutes of Health, Bethesda, have indicated that in healthy individuals, variation in a gene known as AKT1 affects the structure and function of part of the brain that is dysfunctional in individuals with schizophrenia. Specifically, in healthy individuals, one particular AKT1 variant was associated with impaired cognition (an impaired ability to process information), something that is markedly affected in individuals with schizophrenia. In addition, the same AKT1 variant was associated with decreased grey-matter volume in the frontostriatal region of the brain, which is dysfunctional in individuals with schizophrenia. Further analysis indicated that the AKT1 variant was associated with an increased risk of schizophrenia and the therapeutic implications of this, as well as the other results of the study, are discus
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Contact: Karen Honey
press_releases@thje-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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