Navigation Links
JCI table of contents: May 22, 2008
Date:5/22/2008

w.the-jci.org/article.php?id=34267


EDITOR'S PICK: What identifies cancer cells causing relapse and metastasis? Not CD133

New data, generated by Shahin Rafii and colleagues, at Weill Medical College of Cornell University, New York, through analysis of human colon cancer cells and mice, have shed doubt on the recently proposed designation of the protein CD133 as a marker of colon cancer stem cells a term given to the small number of cells within a colon cancer that are thought to be able to give rise to a new tumor and that therefore are responsible for tumor recurrence and metastasis.

In the study, mice were engineered such that they expressed a reporter protein everywhere that CD133 is normally expressed. In contrast to previous studies in which CD133 expression had been shown to be expressed by very few cells in the colon, this reporter protein was detected in many cells in the colon, including nonstem cells. A similarly broad expression of CD133 in the colon of both mice and humans was observed using antibodies that bind CD133. Analysis of human and spontaneous mouse primary colon tumors indicated that CD133 was expressed by most cells. Conversely, not all human colon cancer cells that had metastasized to the liver expressed CD133. Further, both the CD133+ and CD133 cells generated tumors when transplanted into immunocompromised mice. Some of the reasons why this study and previous investigations reached such distinct conclusions as to whether or not CD133 is a marker of colon cancer stem cells are noted by the authors and discussed in detail in an accompanying commentary by Mark LaBarge and Mina Bissell, at Lawrence Berkeley National Laboratory, Berkeley.

TITLE: CD133 expression is not restricted to stem cells, and both CD133+ and CD133 metastatic colon cancer cells initiate tumors

AUTHOR CONTACT:
Shahin Rafii
Weill Medical College of Cornell University, New York, New York, USA. '/>"/>

Contact: Karen Honey
press_releases@thje-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine news :

1. New Survey Suggests That Consumers Are Naive to the Risk of Botox Parties and the Importance of FDA Approval for Cosmetic Injectables
2. Eat Your Vegetables - That Means You, Parents!
3. Biotel Announces Profitable Third Quarter Ended March 31, 2008
4. Mylan Launches Paroxetine Hydrochloride Extended-Release Tablets
5. FDA Approves NOVO NORDISKs NovoSeven(R) RT (Coagulation Factor VIIa [Recombinant] Room Temperature Stable) for Hemophilia Patients With Inhibitors
6. Dawning Technologies, Inc. Releases JavaLin/PDI Portable Device Interface
7. SEIU Members to Politicians: Live Up to Your Promises or We Will Hold You Accountable
8. Dr. Arnold Klein Warns of Dangers With Permanent and Longer Lasting Injectable Fillers
9. Roxane Laboratories, Inc. Announces the Launch of Acarbose Tablets
10. After divorce, stable families help minimize long-term harm to children
11. Pilot study reinforces use of portable anteroom HEPA filtration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... New York, NY (PRWEB) January 22, 2015 ... component of overall health care gains momentum worldwide, Rev. ... York-based HealthCare Chaplaincy Network (HCCN), will be the ... advance spiritual care in Israel’s public health system. , The ...
(Date:1/22/2015)... has released a new blog post presenting a list of vehicles ... , Some types of vehicles cannot be covered under an ... post to see if their vehicle qualifies for auto insurance coverage. ... the cars that cannot be covered by a plan. Clients have ...
(Date:1/22/2015)... VA (PRWEB) January 22, 2015 Step ... power at the Science Museum of Virginia. Wicked Plants, ... , Wicked Plants unearths 75 poisonous, carnivorous and diabolical ... through each room to uncover the biochemical, physical and ...
(Date:12/26/2014)... December 26, 2014 The US represents the ... report. In 2013, GlobalData’s forecast estimates that sales of branded ... market due to the high incidence of the disease, high ... 5EU, Japan, and China. Increased sales of CRC therapies over ...
(Date:12/26/2014)... Cooking and warming equipment has ... score reflects slightly positive negotiation conditions for buyers, stemming from ... a low level of price volatility. “However, buyer power is ... warming equipment and high volatility in the world price of ...
Breaking Medicine News(10 mins):Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2Health News:Wicked Plants are taking over the Science Museum of Virginia 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 3Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 4Health News:Cooking & Warming Equipment Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Cooking & Warming Equipment Procurement Category Market Research Report from IBISWorld has Been Updated 3
... behavior change, DES MOINES, Iowa, Oct. 10 ... good things about the current,health care system, but major ... Survey. The survey was released today by the,Employee Benefit ... underwritten by the Principal Financial Group(R)., To view ...
... 10 NuView Life Sciences Inc.,(NuView) has agreed ... including operations of the linear accelerator and cyclotron,production ... Copper- 67, Indium-111, Iodine-123 and Thallium-201 used in,molecular ... and,CEO, stated that "We are confident that by ...
... Public interest,advocates(1) welcomed the results of a global ... mercury to human health and environment.,On 6-10 October 2008, ... agreed on the elements that would form part of ... Governing Council (GC) in February,2009, where it will be ...
... avoiding radiation could lessen long-term side effects, study finds ... chemotherapy alone, and delaying or avoiding radiation altogether, may ... low-grade glioma brain tumors, according to a multi-institutional study. ... in children. If surgery can be performed, the survival ...
... implementation of electronic health records (EHRs), the Healthcare Information and ... Davies Awards in the Organizational, Ambulatory and Community Health Organization ... ... October 10, 2008 -- Honoring excellence in the implementation of ...
... a $5,807,469 grant over five years from the National Institute ... Older Americans Independence Center. BMC,s Pepper Center is one of ... Claude D. Pepper Older Americans Independence Center Program was established ... from Florida. During his five decades of public service, Pepper ...
Cached Medicine News:Health News:Video: Just What the Doctor Ordered: Survey Shows Americans Adopting Healthier Lifestyles 2Health News:Video: Just What the Doctor Ordered: Survey Shows Americans Adopting Healthier Lifestyles 3Health News:Elements for a UN Global Framework on Mercury Agreed to 2Health News:Chemo Alone Effective in Treating Kids' Brain Tumors 2Health News:2008 HIMSS Davies Awards: Nation's Outstanding Healthcare Organizations Recognized 2Health News:2008 HIMSS Davies Awards: Nation's Outstanding Healthcare Organizations Recognized 3Health News:2008 HIMSS Davies Awards: Nation's Outstanding Healthcare Organizations Recognized 4Health News:2008 HIMSS Davies Awards: Nation's Outstanding Healthcare Organizations Recognized 5Health News:Boston Medical Center receives $5.8m grant 2
(Date:1/23/2015)... 2015  MedScope ( www.medscope.org ), the leading provider of ... Connected World magazine Connected World Award for ... can be used anywhere, anytime. The nomination was made ... In nominating MedScope, Landon Garner , Director of ...
(Date:1/23/2015)... , Jan. 23, 2015 /PRNewswire/-- Harwood Feffer LLP ( ... of directors of Advaxis, Inc. ("Advaxis" or the "Company") ... has breached its fiduciary duties to shareholders. ... an investing website reporting that Advaxis had misrepresented the ...
(Date:1/23/2015)... Idaho , Jan. 23, 2015  Now available for ... No. 7,849,611) support that prevents ankle sprains by cushioning ... brace, it fits securely around the outside of any ... mobility & comfort while still offering protection against sprains. ...
Breaking Medicine Technology:MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2
... an Interventional Radiology Treatment -- Detailed for Those ... Osteoplasty -- a highly effective minimally invasive procedure ... disease by injecting bone cement to support weakened ... often presenting individuals who are suffering terribly with ...
... Any Age: Comparison by Interventional Radiologists Shows No ... FistulasSAN DIEGO, March 9 A new study ... disease, it doesn,t matter if you,re young or ... for maintaining access to one,s circulatory system to ...
Cached Medicine Technology:Metastatic Bone Disease Patients Can Walk in Lazarus' Footsteps 2Metastatic Bone Disease Patients Can Walk in Lazarus' Footsteps 3Metastatic Bone Disease Patients Can Walk in Lazarus' Footsteps 4Metastatic Bone Disease Patients Can Walk in Lazarus' Footsteps 5For Old or Young Dialysis Patients, AV Fistulas Remain Pure Gold 2For Old or Young Dialysis Patients, AV Fistulas Remain Pure Gold 3For Old or Young Dialysis Patients, AV Fistulas Remain Pure Gold 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: