Navigation Links
JCI table of contents: May 22, 2008
Date:5/22/2008

EDITOR'S PICK: Anti-HIV drugs reduce the cause of some forms of vision loss

A potential new therapeutic use for anti-HIV drugs known as protease inhibitors has been suggested by a team of researchers from Harvard Medical School, Boston, and Inserm U848, France, as a result of their work in a mouse model of retinal detachment.

An important cause of vision loss in many diseases of the eye is the death (by a process known as apoptosis) of nerve cells in the eye (known as photoreceptors) after retinal detachment. In the study, administration of HIV protease inhibitors by mouth markedly decreased photoreceptor apoptosis in the mouse model of retinal detachment. Mechanistic analysis in mouse retinal cell cultures and in mice expressing decreased amounts of specific proteins established that the HIV protease inhibitors disrupted two molecular pathways that cause apoptotic cell death, both of which affect the cell compartments known as mitochondria. As the same apoptotic cell deathinducing pathways were shown to be activated in human retinas after retinal detachment, the authors suggest that although the HIV protease inhibitors cannot reattach the retina, they might be of clinical benefit through their ability to prevent the photoreceptor apoptosis that has a central role in vision loss after retinal detachment.

TITLE: HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice

AUTHOR CONTACT:
Joan W. Miller
Harvard Medical School, Boston, Massachusetts, USA.
Phone: (617) 573-3526; Fax: (617) 573-3364; E-mail joan_miller@meei.harvard.edu.

Guido Kroemer
INSERM U848, Villejuif (Paris), France.
Phone: 33-1-42-11-60-46; Fax: 33-1-42-11-60-47; E-mail kroemer@igr.fr.

View the PDF of this article at: https://ww
'/>"/>

Contact: Karen Honey
press_releases@thje-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine news :

1. New Survey Suggests That Consumers Are Naive to the Risk of Botox Parties and the Importance of FDA Approval for Cosmetic Injectables
2. Eat Your Vegetables - That Means You, Parents!
3. Biotel Announces Profitable Third Quarter Ended March 31, 2008
4. Mylan Launches Paroxetine Hydrochloride Extended-Release Tablets
5. FDA Approves NOVO NORDISKs NovoSeven(R) RT (Coagulation Factor VIIa [Recombinant] Room Temperature Stable) for Hemophilia Patients With Inhibitors
6. Dawning Technologies, Inc. Releases JavaLin/PDI Portable Device Interface
7. SEIU Members to Politicians: Live Up to Your Promises or We Will Hold You Accountable
8. Dr. Arnold Klein Warns of Dangers With Permanent and Longer Lasting Injectable Fillers
9. Roxane Laboratories, Inc. Announces the Launch of Acarbose Tablets
10. After divorce, stable families help minimize long-term harm to children
11. Pilot study reinforces use of portable anteroom HEPA filtration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... (PRWEB) July 29, 2014 Gummy smile ... and dark gums treatments that can enhance and perfect ... a balanced appearance that displays the teeth to their best ... gum tissue or have gums that are dark or discolored. ... to feel self-conscious about their smiles or experience a high ...
(Date:7/29/2014)... Kathleen Doheny HealthDay ... Healthy women at low risk of cardiovascular disease may be ... a short time without harming their hearts, according to a ... Initiative, found that hormone replacement therapy had harmful effects on ... they began the hormone treatments, and much further past menopause. ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 iFitDress.com, one of ... its new selection of 2014 high low wedding dresses ... new gowns are offered at discounted prices, up to 68% ... the big discounts before August 05. , The ... of high low wedding dresses. In the new collection, there ...
(Date:7/29/2014)... WA (PRWEB) July 29, 2014 “Approximately ... one of the most common chronic illnesses,” Western Washington ... addressing the need for those suffering from allergies ... spent on allergy-related health care each year in the ... as a mere way of life for themselves, rather ...
(Date:7/29/2014)... "Acceptance, Recognition, and Control (A.R.C.) Against ... own demons and wants other men to heed the call ... A month later, he had no job, leaving Raymond with ... approached the government for assistance, the emotional disturbance was so ... But this approach didn’t get to the root of his ...
Breaking Medicine News(10 mins):Health News:Gummy Smile Surgeon, Dr. Alex Farnoosh, Now Offers Procedures to Improve Gummy Smiles and Dark Gums 2Health News:Early Hormone Therapy May Be Safe for Women's Hearts 2Health News:Early Hormone Therapy May Be Safe for Women's Hearts 3Health News:2014 High Low Wedding Dresses Provided By iFitDress.com 2Health News:Allergy Sufferers are Urged to Seek Medical Help in Recent Article by Western Washington Medical Group 2Health News:Allergy Sufferers are Urged to Seek Medical Help in Recent Article by Western Washington Medical Group 3Health News:SBPRA Announces the Release of Its Newest Title, "Acceptance, Recognition, and Control (A.R.C.) Against Depression" 2
... from Scripps Research Institute, have identified a sensor that identifies ... of glucose. It acts like a switch that increases or ... other times it helps to convert glucose into fat for ... named Liver X Receptor. Its dual function makes it a ...
... largely to the socializing that takes place there, according to ... keeping fit and losing weight but also for meeting new ... Professor of Social Sciences from the University of Manchester, spent ... motivating them to join health clubs. He wanted to study ...
... promises heavy investment opportunities for Non-Resident Keralites (NRK), making ... long term. ,Kerala Tourism Department has ... 23 – 27 for showcasing the opportunities in the ... a congregation of major hospitals, health insurance companies, policy ...
... malnutrition. In spite of hospitalization the survival rate is less ... a research published concerning certain clinical signs that would indicate ... are at greater risk. ,The international group of researchers ... where 920 children were admitted with severe malnutrition between Septemb ...
... A new study provides the strongest evidence yet that a ... testing and risk assessment// for toxins is wrong when it ... ,Edward J. Calabrese, a scientist at the University of Massachusetts ... 56,000 tests in 13 strains of yeast using 2,200 drugs, ...
... has for the first time identified several genes// whose expression ... cancers – lung, breast, prostate and colon cancer. ,The ... genes, is often lost in tumor cells. This can occur ... deletion of the gene. Loss of tumor suppression function also ...
Cached Medicine News:Health News:Glucose Sensor That Controls Glucose Metabolism Identified 2Health News:New Study Challenges How Regulators Determine Risk 2Health News:Profiling of Cancer Genes May Lead to Earlier Detection Human Cancers 2Health News:Profiling of Cancer Genes May Lead to Earlier Detection Human Cancers 3
(Date:7/29/2014)... July 29, 2014  Cloud Pharmaceuticals, Inc., a ... development, announced today that it has been awarded ... Foundation Small Business Innovation Research (NSF SBIR) program. ... Cloud Pharmaceuticals designs new drugs and drug ... new, innovative cloud computing technology in place of ...
(Date:7/29/2014)... -- Encision Inc. (OTCQB:ECIA), a medical device company owning patented ... minimally invasive surgery, today announced financial results for its ... The Company posted quarterly net revenue of $2.476 ... or $(0.02) per share. These results compare to net ... $311 thousand, or $(0.04) per share, in the year-ago ...
(Date:7/29/2014)... July 29, 2014   ... that it has taken an exclusive worldwide licence to ... a Durham University spin-out company. ... pay an upfront fee, development and commercial milestone payments, ... also taken an option for additional exclusive licences to ...
Breaking Medicine Technology:Cloud Pharmaceuticals Receives Phase I NSF SBIR Grant Valued at $150,000 2Encision Reports First Quarter Fiscal Year 2015 Results 2Encision Reports First Quarter Fiscal Year 2015 Results 3Encision Reports First Quarter Fiscal Year 2015 Results 4Glide Pharma Takes Exclusive Worldwide Rights to Novel Diagnostic Technology for Prostate Cancer 2Glide Pharma Takes Exclusive Worldwide Rights to Novel Diagnostic Technology for Prostate Cancer 3
1.7% Tryptone, 0.3% Soytone, 0.5% Sodium Chloride, 0.25% Dextrose, 0.25% Potassium Phosphate....
Penicillin G (1 x 10 4 units/mL and Streptomycin (10mg/mL) Solution. 100X Concentrate....
Penicillin-Streptomycin-Glutamine (100X) liquid...
Contains 10,000 units of penicillin (base), 10,000 g of streptomycin (base), and 25 g of amphotericin B/ml utilizing penicillin G (sodium salt), streptomycin sulfate, and amphotericin B as Fungizone ...
Medicine Products: