Navigation Links
JCI table of contents: March 23, 2009
Date:3/23/2009

p>ACCOMPANYING COMMENTARY
TITLE: The voltage-gated K+ channel subunit, Kv1.1, links kidney and brain

AUTHOR CONTACT:
David H. Ellison
Oregon Health & Science University, Portland, Oregon, USA.
Phone: (503) 494 7159; Fax: (503) 494-5330; E-mail: ellisond@ohsu.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=38835


NEPHROLOGY: Protective role for kallikrein proteins in kidney disease

A team of researchers, at the University of Texas Southwestern Medical Center, Dallas, and Uppsala University, Sweden, has shed new light on several forms of the kidney disease known as nephritis. Specifically, the data indicate a protective role for kallikrein proteins in anti-GBM antibodyinduced nephritis (a mouse model of Goodpasture syndrome) and spontaneous lupus nephritis in mice and humans.

In the study, which was led by Chandra Mohan, Edward Wakeland, and Marta Alarcn-Riquelme, kallikrein genes were found to be underexpressed in the kidneys of mouse strains sensitive to anti-GBM antibodyinduced nephritis. Conversely, mouse strains that upregulated kallikreins in the kidneys showed fewer signs of disease. Consistent with this, antagonizing the kallikrein pathway enhanced disease and agonists dampened disease severity. As both human systemic lupus erythematosus and spontaneous lupus nephritis were found to be associated with kallikrein genes, the authors conclude that kallikreins are protective disease-associated genes in anti-GBM antibodyinduced nephritis and lupus. In an accompanying commentary, Claudio Ponticelli and Pier Luigi Meroni, at IRCCS Istituto Clinico Humanitas, Italy, discuss this possibility and suggest alternative roles for kallikreins in lupus nephritis.

TITLE: Kallikrein genes are associated with lupus and glomerular basement membranespecific antib
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Ranbaxy Receives Tentative Approval to Manufacture and Market Galantamine Tablets on an Exclusive Basis
2. Schering-Plough/Merck Pharmaceuticals Announce FDA Filing Acceptance of New Drug Application for Loratadine/Montelukast Tablet
3. JCI table of contents: Sept. 4, 2007
4. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
5. Actavis Launches Carvedilol Tablets in the U.S.
6. Mylan Announces Final FDA Approval for Carvedilol Tablets
7. Ranbaxy Gains Approval to Manufacture and Market Carvedilol Tablets in the U.S. Market
8. Actavis Launches Amlodipine Tablets in the U.S.
9. Implantable device designed to detect, stop seizures under study at MCG
10. Stevens Health, Technology and Society roundtable: Sept. 19
11. Fruity vegetables and fish reduce asthma and allergies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... The report "Indoor Location Market ... and Navigation, Location based analytics, Location based ... Market Forecasts and Analysis (2014 - 2019)" ... into various sub-segments with an in-depth analysis ... identifies the factors driving this market, various ...
(Date:8/21/2014)... therapy for depression has the added benefit of reducing ... doctors, according to a new study by the Centre ... Institute for Clinical Evaluative Sciences (ICES). , The research ... cognitive therapy showed a significant reduction in non-mental health ... who received other types of group therapy. , ...
(Date:8/21/2014)... As part of a continuing mission to ... joined with the Alliance for Safe Online Pharmacies (ASOP) ... sale of medicines. , “Helping to ensure the quality, ... a core mission for USP and an important tool ... T. Piervincenzi, chief executive officer of USP. “The illegal ...
(Date:8/21/2014)... According to a new market report published ... Industry Analysis, Size, Share, Growth, Trends and Forecast, 2012 ... at USD 236.1 million in 2011 and is estimated ... 2018 at a CAGR of 6.3% from 2012 to ... http://www.transparencymarketresearch.com/fundus-cameras.html . , Fundus cameras market growth in ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 Tibet has ... explore the mysterious mountaintop kingdom. Prayers flags whip ... Himalayas and the low rumble of chanting monks fill ... roof of the world’, access to Tibet is challenging ... the foreign land can prove to be daunting for ...
Breaking Medicine News(10 mins):Health News:Indoor Location Market Worth $3.9 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Indoor Location Market Worth $3.9 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Indoor Location Market Worth $3.9 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Mindfulness-based depression therapy reduces health care visits 2Health News:USP Joins Efforts to Halt Illegal Online Drug Sales 2Health News:Fundus Cameras Market: Product Type- Mydriatic, Non-Mydriatic, Hybrid and ROP Cameras; End Users- Hospitals, Ophthalmology Clinics and Ophthalmic & Optometrist Offices 2
... Inc. (Nasdaq:,ENMD), a clinical-stage pharmaceutical company developing therapeutics ... reported financial,results for the three months ended March ... The Company reported a net loss for ... per share, compared with a net loss of ...
... Musician/photographer captures celebrity images for non-profit hearing ... awareness ... and,official photographer of the Hear the World initiative, today introduced,his photography ... exhibit. Last night,s opening was timed to celebrate the,beginning of Better ...
... ... Healthcare, OAKLAND, Calif., May 1 With talk of a ... poll,this week illustrates that Californians will once again pay particular,attention to ... poll this week by the influential Field Institute released documented,that CNA ...
... 1 LifeStem,International, Inc., (OTC Bulletin Board: LSTM), ... life sciences company,concentrating on the collection and banking ... today announced that as of May 2, it ... trading symbol, effected a,3000 for 1 reverse stock ...
... , , THURSDAY, May 1 (HealthDay News) -- Not having money ... than those making more money, according to a study that ... scored their feelings of pain on a scale of 0 ... household incomes below $30,000 a year reported moderate to severe ...
... a Unified National Acute Coronary Syndromes Registry,to Measure ... 1 The American College of,Cardiology Foundation,s National ... Get With The Guidelines(SM),(GWTG)-Coronary Artery Disease (CAD) Registry ... national unified registry for measuring and,improving safety and ...
Cached Medicine News:Health News:EntreMed Reports First Quarter 2008 Financial Results 2Health News:EntreMed Reports First Quarter 2008 Financial Results 3Health News:EntreMed Reports First Quarter 2008 Financial Results 4Health News:Photo: Bryan Adams Unveils Hear the World Ambassadors Photo Exhibit 2Health News:Photo: Bryan Adams Unveils Hear the World Ambassadors Photo Exhibit 3Health News:Field Poll: California Nurses Association Most Favorably Viewed Group in Healthcare Arena 2Health News:Field Poll: California Nurses Association Most Favorably Viewed Group in Healthcare Arena 3Health News:CalbaTech, Inc. Officially Changes Name to LifeStem International, Inc.; Lists New Symbol (LSTM) and Launches New Web Site 2Health News:Less Money Means More Hurting 2Health News:Less Money Means More Hurting 3Health News:The American College of Cardiology Foundation's NCDR(R) and the American Heart Association's GWTG Join Forces to Fight Heart Attacks 2Health News:The American College of Cardiology Foundation's NCDR(R) and the American Heart Association's GWTG Join Forces to Fight Heart Attacks 3
(Date:8/21/2014)... Aug. 21, 2014  Decision Resources Group finds ... Brazil and ... and commonly prescribe long-acting beta-agonist (LABA)- and long-acting ... so within current severe cost/coverage constraints. Therefore, new ... expected to launch in these countries—which will considerably ...
(Date:8/21/2014)... , Aug. 21, 2014  Seventy-one percent of Americans ... OxyContin is a serious public health and safety issue in ... from a survey released today by Repass & Partners, a ... "Americans understand the severity of the prescription medication ... progress with this very serious health situation facing our country," ...
(Date:8/21/2014)... Aug. 21, 2014  Henry Schein, Inc. (NASDAQ: ... and services to office-based dental, animal health and medical practitioners, ... conferences in September: , September 4, 2014 – ... , NY at 12:50 p.m. ET , September 8, 2014 ... New York , NY at 1:25 p.m. ET ...
Breaking Medicine Technology:Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3Henry Schein To Present At Two Investor Conferences In September 2
... 4, 2011 /PRNewswire-Asia-FirstCall/ -- Dehaier Medical Systems Ltd. ... "Company"), an emerging leader in the development, assembly, marketing ... in China, today announced that it will release financial ... June 30, 2011 on Monday, August 15, 2011 before ...
... Medical, Inc. (OTCBB: HASC), www.mysouthernmed.com , a ... Florida, and Mississippi, announced today that the Chairman ... guaranteed the financing that was used for the ... on May 17th, 2011. As part ...
Cached Medicine Technology:Dehaier Medical to Report Second Quarter 2011 Financial Results on August 15 2HASCO Medical Chairman Provides $2 Million in Capital and a Personal Guarantee on Additional $2 Million Promissory Note 2HASCO Medical Chairman Provides $2 Million in Capital and a Personal Guarantee on Additional $2 Million Promissory Note 3
... to U.S. and international engineering and ... Screw and Plating System* provides seamless ... of use for open reduction internal ... TC-100 system works well beyond the ...
... The Alphatec Small Fragment ... wide range of fractures, including ... distal humerus, distal radius, distal ... malleolus, metatarsals, and metacarpals. The ...
Stainless steel threaded Steinman Pins available in point types A,D, E, and F....
Round Bevel-Point Pin Sets available in 2.3mm, 3.1mm, 4.7mm, and 6.3mm sizes....
Medicine Products: