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JCI table of contents: March 23, 2009
Date:3/23/2009

pher Baum, at Hannover Medical School, Germany, discuss the clinical importance of these data and the numerous questions that they pose for future research.

TITLE: The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

AUTHOR CONTACT:
Eugenio Montini
San Raffaele-Telethon Institute for Gene Therapy, Milan, Italy.
Phone: 39-02-26433869; Fax: 39-02-26434621, E-mail: montini.eugenio@hsr.it.

Luigi Naldini
San Raffaele-Telethon Institute for Gene Therapy, Milan, Italy.
Phone: 39-02-26434681; Fax: 39-02-26434621, E-mail: naldini.luigi@hsr.it.

View the PDF of this article at: https://www.the-jci.org/article.php?id=37630

ACCOMPANYING COMMENTARY
TITLE: Preventing and exploiting the oncogenic potential of integrating gene vectors

AUTHOR CONTACT:
Christopher Baum
Hannover Medical School, Hannover, Germany.
Phone: 49-511-532-6069; Fax: 49-511-532-6068; E-mail: baum.christopher@mh-hannover.de.

View the PDF of this article at: https://www.the-jci.org/article.php?id=38831


ONCOLOGY: Too much oxygen not a good thing for tumors

As tumors grow, some regions lack a blood supply adequate to maintain good levels of oxygen, that is some regions become hypoxic. This is a hallmark of malignant tumors and has been suggested, but not experimentally proven, to promote tumor progression. However, Paolo Michieli and colleagues, at the University of Turin Medical School, Italy, have now developed xenograft models to examine how human lung tumors without regions of hypoxia develop and found that tumors re
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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