Navigation Links
JCI table of contents: March 20, 2008
Date:3/20/2008

acy in rodent models of autoimmune diseases. New data generated by Holger M. Reichardt and colleagues at the University of Goettingen Medical School, Germany, has now provided more insight into the effects of drugs similar to TGN1412 in rats, but as with the preclinical trials no evidence of the devastating consequences in humans were observed. As pointed out in an accompanying commentary by William St. Clair, at Duke University Medical Center, Durham, these data serve to highlight the different responses of rodents and humans to drugs like TGN1412, and raise questions about how best to design preclinical studies that can better predict the risks of novel immunotherapeutics in humans.?

TITLE: A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats

AUTHOR CONTACT:
Holger M. Reichardt
University of Goettingen Medical School, Goettingen, Germany.
Phone: 49-551-393365; Fax: 49-551-395843; E-mail: hreichardt@med.uni-goettingen.de.

View the PDF of this article at: https://www.the-jci.org/article.php?id=32698

ACCOMPANYING COMMENTARY

TITLE: The calm after the cytokine storm: lessons from the TGN1412 trial

AUTHOR CONTACT:
E. William St. Clair
Duke University Medical Center, Durham, North Carolina, USA.
Phone: (919) 684-4499; Fax: (919) 684-8358; E-mail: stcla003@mc.duke.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=35382


ONCOLOGY: The protein TM4SF5 lets tumor cells grow out of control

A characteristic of tumor cells is that they grow in an uncontrolled manner. One reason for this is that although normal cells stop growing when they contact one another (a process
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Blue Cross and Blue Shield of Illinois Announces 2007 Charitable Donations
2. GSK Charitable Support Valued at $564 Million in 2007
3. JCI online early table of contents: March 13, 2008
4. Implantable medical devices may expose patients to security, privacy risks; solutions suggested
5. Perrigo Company to Market Over-the-Counter Cetirizine Hydrochloride, Pseudoephedrine Hydrochloride Extended-Release Tablets
6. Perrigo Company Announces Initial Shipments of Store Brand Omeprazole Tablets
7. V8 V-Fusion(R) Takes an Exotic, Tasty Twist on Vegetable Juice
8. JCI online early table of contents: March 3, 2008
9. AXA Equitable Meets the Needs of Two People under One Life Insurance Policy
10. Nanomedicine system engineered to enhance therapeutic effects of injectable drugs
11. Nurses Convince Hospital to Return to Bargaining Table
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Norton HealthDay Reporter , TUESDAY, ... the three Ebola cases in Dallas. But, mental health specialists ... Americans. President Barack Obama on Friday appointed an Ebola ... has infected two Dallas nurses who cared for a Liberian ... Presbyterian Hospital. But the U.S. cases are miniscule in ...
(Date:10/22/2014)... Shriners Hospitals for Children® and UK ... current location of Shriners Hospitals for Children - Lexington ... the University of Kentucky Albert B. Chandler Hospital. The ... owned and operated by Shriners Hospitals for Children, and ... and their families well into the future. , “The ...
(Date:10/22/2014)... Los Angeles, California (PRWEB) October 22, 2014 ... Recovery 2.0: Move Beyond Addiction and Upgrade Your Life (Paperback; ... the field of Yoga & Recovery. This book is ... and thrive in a life of recovery. , Recovery ... of the 12 Steps; Recovery 2.0 is a guide for ...
(Date:10/22/2014)... 22, 2014 During the Western United ... supply runs dangerously low, Southern Oregon’s water is proving ... despite the lowest mountain snow pack on record in ... and early autumn.* That was the observation of journalist-hikers ... book “Hiking Southern Oregon,” during an interview with water ...
(Date:10/22/2014)... Texas (PRWEB) October 22, 2014 ... of completing their continuing education at home or ... have access to 20 brand new, premium Seminar-on-Demand ... robust catalog of over 2,000 hours ... fully customize their educational experience. With such a ...
Breaking Medicine News(10 mins):Health News:Ebola Anxiety: A Bigger Threat Now Than the Virus Itself 2Health News:Ebola Anxiety: A Bigger Threat Now Than the Virus Itself 3Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2
... is high time for the medicine industry to embrace ... would help identify fake medicines. // ,Alarmingly, ... cheat customers have been found to contain even poisonous ... profit and have remained the target of crime gangs. ...
... Australian children, according to reports published today in the ... lead to a host of problems including brain damage, ... Eastman, one among Australia’s leading endocrinologists has co-authored these ... the authorities who seem to be very slow in ...
... will now form part of a unique experiment that will ... of the Scots. // ,7000 Scots will be ... motive to change the reputation of Europe, now known as ... of the largest ever study conducted in Europe that will ...
... has warned that almost one third of the Nurses will refuse to ... indicated that anything less than a 3% payaward, would tantamount to NHS ... // ,NHS nurses work overtime on an avergae of ... would cost the NHS ?8 million a week. ,Chancellor Gordon ...
... quite a trend setter of sorts. Now, BT Offices and ... // that smoking is banned in the BT premises as ... 26. Importantly, this move might encourage “anti-smoking” initiatives in other ... this announcement, which will surely set a precedent. Now this ...
... consider their Parents to be the most authentic source for ... ,Among 1171 teens who took part in the ... 63% named the Parents as a key Knowledge disseminator about ... part of their knowledge to their experience in schools and ...
Cached Medicine News:Health News:Need For Smarter Ways To Identify Fake Drugs & Internet Counterfeiting: WHO 2
(Date:10/22/2014)... 2014  Charlene Vernak, RPh, of Vernak Farms Pharmacy ... was awarded the George Roentsch Scholarship by the Professional ... in Houston during PCCA,s International ... annually to an independent pharmacist and PCCA member who ... Roentsch , a well-known pharmacist in the compounding community. ...
(Date:10/22/2014)... DIEGO , Oct. 22, 2014 AVACEN ... medical device received 510 (k) OTC clearance by the ... AVACEN 100 to be marketed over the Internet for: ... arthritis; muscle spasms; and minor strains and sprains . ... The AVACEN 100 (MSRP $2495) is a sophisticated ...
(Date:10/22/2014)... , October 22, 2014 ... ), a clinical-stage pharmaceutical company focused on the ... positive top-line clinical results from its Phase IIa ... insulin capsules, to treat type 1 diabetes. The trial ... under a U.S. Food and Drug ...
Breaking Medicine Technology:PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 2Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 3Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 4
... recognized for identifying healthy solutions that empower men and women ... natural supplement which includes an ingredient that clinical tests revealed ... by 98%. Men who take Mdrive daily report ... focus. Mdrive - A synergistic blend ...
... ReportsnReports - U.S. Rehabilitation Technology Market ... This research service covers the following market ... electrotherapy - muscle Stimulators, clinical electrotherapy - ultrasound, ... diathermy, continuous passive motion (CPM) machines, clinical treatment ...
Cached Medicine Technology:DreamBrands New Formula Helps Men Feel Younger and Stronger While Naturally Raising Low-T Without Prescription Drugs 2ReportsnReports Adds Market Research Report on U.S. Rehabilitation Technology Market in its Store 2ReportsnReports Adds Market Research Report on U.S. Rehabilitation Technology Market in its Store 3ReportsnReports Adds Market Research Report on U.S. Rehabilitation Technology Market in its Store 4ReportsnReports Adds Market Research Report on U.S. Rehabilitation Technology Market in its Store 5