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JCI table of contents: March 20, 2008
Date:3/20/2008

acy in rodent models of autoimmune diseases. New data generated by Holger M. Reichardt and colleagues at the University of Goettingen Medical School, Germany, has now provided more insight into the effects of drugs similar to TGN1412 in rats, but as with the preclinical trials no evidence of the devastating consequences in humans were observed. As pointed out in an accompanying commentary by William St. Clair, at Duke University Medical Center, Durham, these data serve to highlight the different responses of rodents and humans to drugs like TGN1412, and raise questions about how best to design preclinical studies that can better predict the risks of novel immunotherapeutics in humans.?

TITLE: A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats

AUTHOR CONTACT:
Holger M. Reichardt
University of Goettingen Medical School, Goettingen, Germany.
Phone: 49-551-393365; Fax: 49-551-395843; E-mail: hreichardt@med.uni-goettingen.de.

View the PDF of this article at: https://www.the-jci.org/article.php?id=32698

ACCOMPANYING COMMENTARY

TITLE: The calm after the cytokine storm: lessons from the TGN1412 trial

AUTHOR CONTACT:
E. William St. Clair
Duke University Medical Center, Durham, North Carolina, USA.
Phone: (919) 684-4499; Fax: (919) 684-8358; E-mail: stcla003@mc.duke.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=35382


ONCOLOGY: The protein TM4SF5 lets tumor cells grow out of control

A characteristic of tumor cells is that they grow in an uncontrolled manner. One reason for this is that although normal cells stop growing when they contact one another (a process
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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