JCI table of contents: March 20, 2008( BACTERIOLOGY: Antibodies protect ag...),Health

In developed countries, infection with nontyphoidal strains of Salmonella bacteria (NTS) usually occurs through eating contaminated food and causes gastroenteritis. By contrast, in Africa, children under the age of 2 and HIV-infected adults usually develop an infection in the blood (bacteremia), which is fatal in almost a quarter of affected children. There is currently no vaccine against NTS and understanding the immune response that protects against NTS bacteremia is crucial if one is to be developed. New data, generated by Calman MacLennan and colleagues, has now identified a role for antibody in protection against NTS bacteremia in children from Malawi, leading to the suggestion that effective vaccines against NTS should induce the generation of protective antibody.

TITLE: The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children

AUTHOR CONTACT:
Calman A. MacLennan
University of Birmingham, Birmingham, United Kingdom.
Phone: 44-121-414-6944; Fax: 44-121-414-3599; E-mail: c.maclennan@bham.ac.uk.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33998

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