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JCI table of contents: March 20, 2008
Date:3/20/2008

BACTERIOLOGY: Antibodies protect against bacteria in the blood

In developed countries, infection with nontyphoidal strains of Salmonella bacteria (NTS) usually occurs through eating contaminated food and causes gastroenteritis. By contrast, in Africa, children under the age of 2 and HIV-infected adults usually develop an infection in the blood (bacteremia), which is fatal in almost a quarter of affected children. There is currently no vaccine against NTS and understanding the immune response that protects against NTS bacteremia is crucial if one is to be developed. New data, generated by Calman MacLennan and colleagues, has now identified a role for antibody in protection against NTS bacteremia in children from Malawi, leading to the suggestion that effective vaccines against NTS should induce the generation of protective antibody.

TITLE: The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children

AUTHOR CONTACT:
Calman A. MacLennan
University of Birmingham, Birmingham, United Kingdom.
Phone: 44-121-414-6944; Fax: 44-121-414-3599; E-mail: c.maclennan@bham.ac.uk.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33998


GENE THERAPY: Take heed: HOXB4 gene therapy causes leukemia in large animals

Individuals with a number of life-threatening genetic diseases of the immune system have been successfully treated by gene therapy that is, they were infused with early precursors of immune cells that had the correct form of the defective gene delivered into them by agents known as retroviral vectors. However, some patients later developed leukemia. This slowed progress in the field and has led to detailed studies seeking to determine the mechanisms underlying the cause of leukemia an
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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