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JCI table of contents: June 23, 2011
Date:6/23/2011

pithelial progenitor cell: a step forward for cell-based therapies for pulmonary disease

AUTHOR CONTACT:
Jeffrey A. Whitsett
Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Phone: 513.803.2790; Fax: 513.636.7868; E-mail: jeff.whitsett@cchmc.org.

View this article at: http://www.jci.org/articles/view/58704?key=627c5ee85d69eecc49a1


NEPHROLOGY: Long live dopamine production by the kidneys

Dopamine is a natural chemical in the body well known for its role in nerve cell communication; loss of dopamine-producing nerves in a specific region of the brain causes Parkinson disease. However, dopamine also exerts effects on other organs of the body, including the kidneys, where it modulates water transport. The dopamine that acts on the kidneys comes both from the circulation and from the kidneys themselves, which have the capacity to make the chemical, but the roles of these distinct sources of dopamine have not been determined. Raymond Harris, Ming-Zhi Zhang, and colleagues, at Vanderbilt University, Nashville, have now investigated this issue in mice and found that dopamine made within the kidneys is critical for maintaining normal blood pressure. As mice unable to make dopamine within their kidneys developed high blood pressure and lived for a much shorter length of time than normal mice, Harris and colleagues suggest that a functional dopaminergic system in the kidney is important for long-term health and survival.

TITLE: Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice

AUTHOR CONTACT:
Raymond C. Harris
Vanderbilt University School of Medicine and Nashville Veterans Affairs Hospital, Nashville, Tennessee, USA.
Phone: 615.322.2150; Fax: 615.343.2675;
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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