Navigation Links
JCI table of contents: June 20, 2008
Date:6/20/2008

ys

AUTHOR CONTACT:
Sidney A. Simon
Duke University Medical Center, Durham, North Carolina, USA.
Phone: (919) 684-4178; Fax: (919) 684-4431; Email: sas@neuro.duke.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=36111


EDITOR'S PICK: Battle of the bulge: low leptin levels undermine successful weight loss

Individuals who are obese are at increased risk of many diseases, including type 2 diabetes and heart disease. As 75%-95% of previously obese individuals regain their lost weight, many researchers are interested in developing treatments to help individuals maintain their weight loss. A new study, by Michael Rosenbaum and colleagues, at Columbia University Medical Center, New York, has provided new insight into the critical interaction between the hormone leptin and the brain's response to weight loss.

Leptin levels fall as obese individuals lose weight. So, the authors set out to see whether changes in leptin levels altered activity in the regions of the brain known to have a role in regulating food intake. They observed that activity in these regions of the brain in response to visual food-related cues changed after an obese individual successfully lost weight. However, these changes in brain activity were not observed if the obese individual who had successfully lost weight was treated with leptin. These data are consistent with the idea that the decrease in leptin levels that occurs when an individual loses weight serves to protect the body against the loss of body fat. Further, both the authors and, in an accompanying commentary, Rexford Ahima, at the University of Pennsylvania School of Medicine, Philadelphia, suggest that leptin therapy after weight loss might improve weight maintenance by overriding this fat-loss defense.

TITLE: Leptin reverses we
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Ranbaxy Receives Tentative Approval to Manufacture and Market Galantamine Tablets on an Exclusive Basis
2. Schering-Plough/Merck Pharmaceuticals Announce FDA Filing Acceptance of New Drug Application for Loratadine/Montelukast Tablet
3. JCI table of contents: Sept. 4, 2007
4. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
5. Actavis Launches Carvedilol Tablets in the U.S.
6. Mylan Announces Final FDA Approval for Carvedilol Tablets
7. Ranbaxy Gains Approval to Manufacture and Market Carvedilol Tablets in the U.S. Market
8. Actavis Launches Amlodipine Tablets in the U.S.
9. Implantable device designed to detect, stop seizures under study at MCG
10. Stevens Health, Technology and Society roundtable: Sept. 19
11. Fruity vegetables and fish reduce asthma and allergies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... (PRWEB) , ... September 04, 2015 , ... Friday night, ... IL hosting Generation Rescue’s A Night of Hope event supporting families affected by autism, ... and Rowena and Joe Salas, joined together at the Oscar Swan Inn to support ...
(Date:9/3/2015)... CA (PRWEB) , ... September 03, 2015 , ... TransPack ... X. Users can choose from wipes and framing transitions in 30 different styles. ... made exclusively for Final Cut Pro X. , TransPack Toon features 90 cartoon transitions ...
(Date:9/3/2015)... (PRWEB) , ... September 03, 2015 , ... ... agreement with Amerinet Inc., a leading national healthcare solutions organization, to provide electronic ... EMR. , Through this agreement, Amerinet members will receive negotiated pricing on E-Volve ...
(Date:9/3/2015)... ... September 03, 2015 , ... DriButts, a non-profit organization dedicated ... Product Development Group to manufacture a long-lasting reusable diaper for warm weather climates ... to bring 600 DriButts Diapers to rural areas of Haiti during a trip ...
(Date:9/3/2015)... ... 2015 , ... Silverado next week lays the foundation on ... Bellingham, Washington. Silverado Bellingham, a 41,000 square foot, single-story community, is expected to ... 80 people living with Alzheimer’s, dementia and other memory-impairing conditions. , Site ...
Breaking Medicine News(10 mins):Health News:Jenny McCarthy & Donnie Wahlberg Help Raise Over $200,000 For Generation Rescue’s ‘Night Of Hope’ Chicago Charity Event 2Health News:Pixel Film Studios Releases TransPack Toon, a New FCPX Transition 2Health News:E-Volve Health to Offer EMR Consulting Solutions to Amerinet Members 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 3Health News:Site Dedication Ceremony to Celebrate New Silverado Memory Care Community 2
... , , WASHINGTON, July 13 ... society of blood specialists, will honor six scientists who have made ... the newly created Ernest Beutler Lecture and Prize, will be presented ... New Orleans. , , ...
... , ALEXANDRIA, Va., July 13 The nation,s hospice providers ... billion over a ten-year period in the preliminary estimates of the House ... Office. , , These cuts are ... 1 as a result of the elimination of the Budget Neutrality Adjustment ...
... Consumption also appears to undercut effect of cancer-prevention drug, ... especially when it,s beer, increases the risk for highly ... The researchers did not set out to determine the ... rather to test the effectiveness of finasteride (Proscar, Propecia), ...
... than 10 years, the universally accepted lung cancer staging system ... patients with non-small cell lung cancer (NSCLC). A ... the peer-reviewed journal of the American College of Chest Physicians ... Staging Committee of the International Association for the Study of ...
... laws restricting the ability of hospitals to disclose patient ... suffer by more than 24%, according to the Management ... Science , the flagship journal of the Institute for ... drop is seen most clearly in reduced adoption of ...
... you could test your risk for Alzheimer,s disease much like ... UCLA scientists have discovered a way to measure the ... cells in the blood. Amyloid beta forms the plaques considered ... isn,t adequately clearing amyloid beta, it may indicate Alzheimer,s risk, ...
Cached Medicine News:Health News:Six Researchers to Receive Prestigious Awards from the American Society of Hematology 2Health News:Six Researchers to Receive Prestigious Awards from the American Society of Hematology 3Health News:More Cuts to Hospice Announced: Hospice Community Responds with Virtual Lobby Day on July 15 2Health News:Heavy Drinking Linked to Aggressive Prostate Cancer 2Health News:Heavy Drinking Linked to Aggressive Prostate Cancer 3Health News:New lung cancer staging system revealed 2Health News:New lung cancer staging system revealed 3Health News:State privacy rules reduce electronic medical sharing by 24 percent, warns Management Insights 2Health News:UCLA scientists identify how immune cells may help predict Alzheimer's risk 2
(Date:9/3/2015)... ROCHESTER, N.Y. , Sept. 3, 2015 /PRNewswire/ ... provider of clinical trial imaging solutions, announced today, ... providing support for a new philanthropic, epidemiology study ... Africa .  VirtualScopics has teamed up ... children in Zambia.  The image results will be ...
(Date:9/3/2015)... YORK , Sept. 3, 2015  The findings ... are raising disturbing questions about the company,s handling of ... LLP reports.  On September 2 nd , part ... 300 adverse events, including at least 27 fatalities, have ... disclosed a confidential study commissioned by C.R. Bard in ...
(Date:9/3/2015)... DUBLIN , Sept. 3, 2015 Research ... of the "Investigation Report on China Olmesartan Market, ... In 1991, olmesartan medoxomil was successfully developed by Sankyo ... In Apr. 2002, olmesartan medoxomil was approved by FDA ... now become the best- selling drug in the world ...
Breaking Medicine Technology:VirtualScopics, Inc. Collaborates with Large Pharmaceutical Company on a Philanthropic, Epidemiology Study in Africa 2VirtualScopics, Inc. Collaborates with Large Pharmaceutical Company on a Philanthropic, Epidemiology Study in Africa 3VirtualScopics, Inc. Collaborates with Large Pharmaceutical Company on a Philanthropic, Epidemiology Study in Africa 4IVC Filter Lawsuit News: NBC News Investigation into C.R. Bard Recovery Filters Raises Disturbing Questions, Bernstein Liebhard LLP Reports 2IVC Filter Lawsuit News: NBC News Investigation into C.R. Bard Recovery Filters Raises Disturbing Questions, Bernstein Liebhard LLP Reports 3China Olmesartan Investigation Market Report 2010-2019 2
... Millex Filter Units,Filter units with hydrophobic ... Fluoropore membrane are ideal for the ... of sterile containers, and for sterilizing ... 25 mm Millex filter units are ...
... -4C. 5.5 Cubic Ft. ... light. Manual push button ... Two shelves. In-door shelves ... thermostat. Magnetic gasket. Hermetically ...
... Bottled Water, The Simplicity personal water system ... currently use bottled water. In addition to ... store bottled water, your laboratory applications may ... be absorbed from containers and cause water ...
The incorporation of a reverse osmosis (RO) system and an ultrapure water system into a single stand-alone tower provides numerous benefits to the busy laboratory....
Medicine Products: