Navigation Links
JCI table of contents: June 20, 2008
Date:6/20/2008

EDITOR'S PICK: Smoking out the mediators of airway damage caused by pollutants

New insight into how pollution and cigarette smoke damage airways has been provided by Pierangelo Geppetti and colleagues, at the University of Florence, Italy, who studied the effects of such chemicals on guinea pig airways. As discussed, in an accompanying commentary, by Sidney Simon and Wolfgang Liedtke, at Duke University Medical Center, it is hoped that this information will help in the development of therapeutics to combat the effects of pollutants and perhaps help individuals with smoke-related diseases such as chronic obstructive pulmonary disease and chronic asthma.

In the study, chemicals found in cigarette smoke were shown to activate signaling in nerves that ended in the airways of guinea pigs. These effects were abolished using a molecule that inhibited a protein known as TRPA1. Consistent with a central role for TRPA1 in sensing chemicals in cigarette smoke, no signaling in nerves that end in the airways was observed in mice lacking TRPA1 after exposure to the chemicals in cigarette smoke. Further analysis showed that alpha,beta-unsaturated aldehydes were the chemicals that activated TRPA1, suggesting that they might contribute to the airway damage that occurs in smoke-related diseases.

TITLE: Cigarette smokeinduced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents

AUTHOR CONTACT:
Pierangelo Geppetti
University of Florence, Florence, Italy.
Phone: 39-055-427-1329; Fax: 39-055-427-1280; E-mail: pierangelo.geppetti@unifi.it.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34886

ACCOMPANYING COMMENTARY

TITLE: How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airwa
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Ranbaxy Receives Tentative Approval to Manufacture and Market Galantamine Tablets on an Exclusive Basis
2. Schering-Plough/Merck Pharmaceuticals Announce FDA Filing Acceptance of New Drug Application for Loratadine/Montelukast Tablet
3. JCI table of contents: Sept. 4, 2007
4. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
5. Actavis Launches Carvedilol Tablets in the U.S.
6. Mylan Announces Final FDA Approval for Carvedilol Tablets
7. Ranbaxy Gains Approval to Manufacture and Market Carvedilol Tablets in the U.S. Market
8. Actavis Launches Amlodipine Tablets in the U.S.
9. Implantable device designed to detect, stop seizures under study at MCG
10. Stevens Health, Technology and Society roundtable: Sept. 19
11. Fruity vegetables and fish reduce asthma and allergies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... September 03, 2015 , ... Global Vision , the world leader ... spotlighting its award-winning print and artwork inspection solutions, ScanProof and ArtProof at ... at the Olympia London, booth #F33 , Be the first to get a sneak ...
(Date:9/3/2015)... (PRWEB) , ... September 03, 2015 , ... ... speakers for its upcoming virtual conference, “Proven Pharmacy Benefit Strategies for a Rapidly ... as CVS Health, Express Scripts and Milliman, will discuss how plan sponsors are ...
(Date:9/3/2015)... , ... September 03, 2015 , ... Hunters Creek ... Survivor Foundation with a champion AKC Black Lab Puppy. Celebrate Fall 2015 with unlimited ... for friends and family to enjoy Thanksgiving and Christmas with an extra big smile. ...
(Date:9/3/2015)... ... 2015 , ... ProScrub is a set of automated tools that allow Final ... speed effects without the use of keyframes. Utilize ProScrub's powerful sliders to determine ... perfect complements to energetic video productions. ProScrub is a Final Cut Pro ...
(Date:9/3/2015)... ... ... an unavoidable result of incision or injury to the skin. Unsightly as it may be, ... of a scar is dependent on many factors – the size and depth of the ... near invisibility on their own over a period of months,” says Dr. Jocelyn Lieb ...
Breaking Medicine News(10 mins):Health News:Global Vision to Spotlight Intelligent Proofreading at Packaging Innovations 2015 2Health News:Global Vision to Spotlight Intelligent Proofreading at Packaging Innovations 2015 3Health News:Speakers for Upcoming AIS Virtual Conference on Pharmacy Benefit Strategies Include Executives from CVS Health, Express Scripts 2Health News:Hunters Creek Retrievers Is Honored to Support the Lone Survivor Foundation with a Championship Trained Black Labrador Retriever Puppy 2Health News:Hunters Creek Retrievers Is Honored to Support the Lone Survivor Foundation with a Championship Trained Black Labrador Retriever Puppy 3Health News:FCPX Effects Developer Releases ProScrub for Final Cut Pro X 2Health News:Do I Have To Live With That Scar? 2Health News:Do I Have To Live With That Scar? 3Health News:Do I Have To Live With That Scar? 4
... , WEDNESDAY, Sept. 21 (HealthDay News) -- How ... they see a pediatrician, dermatologist or internist, a new ... birth to age 18 are affected by psoriasis, a ... flaky, dry skin. Researchers from University of California, ...
... 21, 2011) A soy germ-based nutritional supplement containing ... skin wrinkles of the outer corner of the eyes ... S-equol have potential to slow skin aging, according to ... in the peer-review journal Menopause and presented ...
... America (ASA) will include more than 1,000 presentations in the ... speech; the science of music; the impact of noise on ... irritating impacts the way we learn, work, and play. ... place October 31 - November 4 in San Diego, California, ...
... (HealthDay News) -- Most of the 220,000 people who undergo ... follow-up procedures they could have to remove any loose skin ... surgeons. However, not all patients who undergo so-called ... dramatic weight loss, said one doctor who,s an obesity expert. ...
... whose work is advancing understanding of neurodegenerative diseases, has ... highest honors bestowed on an individual in the United ... of neurology in the UCSF Memory and Aging Center, ... dementia, a family of neurological syndromes usually afflicting ...
... can invade your bloodstream, break into your brain and ... contagious protozoa infect more than half the world,s population, ... Cornell researchers recently discovered how T. gondii ... it the first known parasite to control its host,s ...
Cached Medicine News:Health News:Kids With Psoriasis Get Inconsistent Care 2Health News:Soy-based natural S-equol supplements improve crow's feet skin wrinkles in menopausal women 2Health News:Soy-based natural S-equol supplements improve crow's feet skin wrinkles in menopausal women 3Health News:Acoustical Society meeting: Highlights and media registration 2Health News:Acoustical Society meeting: Highlights and media registration 3Health News:Acoustical Society meeting: Highlights and media registration 4Health News:Acoustical Society meeting: Highlights and media registration 5Health News:Acoustical Society meeting: Highlights and media registration 6Health News:Many Unaware of Plastic Surgery Options After Weight Loss Procedures 2Health News:UCSF neurologist William Seeley, M.D., named MacArthur Fellow 2Health News:UCSF neurologist William Seeley, M.D., named MacArthur Fellow 3Health News:UCSF neurologist William Seeley, M.D., named MacArthur Fellow 4Health News:Researchers discover how 'promiscuous parasites' hijack host immune cells 2Health News:Researchers discover how 'promiscuous parasites' hijack host immune cells 3
(Date:9/2/2015)... 2, 2015 The quantum dot market report analyzes ... market based on the product includes medical devices, display, and ... lighting, battery and energy storage, QD laser, and transistor. The ... the quantum dot market. The report also provides the geographic ... , Europe , Asia-Pacific ...
(Date:9/2/2015)... YORK , Sept. 2, 2015   About ... the most common laboratory technologies that is used for ... antibodies in solution. ELISA test uses various types of ... phosphatases and the result is detected by photometry or ... the treatment of various infectious diseases such as HIV, ...
(Date:9/2/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/l8z67c/pharmaceutical ) has announced the ... Switzerland - November 26-27, 2015)" conference to their offering. ... of the key areas of pharmaceutical regulatory affairs in ... Macau and Taiwan ... aspects of gaining and maintaining a successful Marketing Authorisation in ...
Breaking Medicine Technology:Quantum Dot Market by Product , Material, Application, and Geography- Forecast up to 2020 2Global Enzyme-Linked Immunosorbent Assay (Elisa) Testing Market 2015-2019 2Global Enzyme-Linked Immunosorbent Assay (Elisa) Testing Market 2015-2019 3Pharmaceutical Regulatory Affairs in China Seminar: Basel, Switzerland - November 26-27, 2015 2
... Feb. 14, 2011 McNicoll, Lewis & Vlak LLC ... industries, announced today that Caroline Corner, Ph. D. has ... where she will cover the Medical Devices and Diagnostics ... (Logo: http://photos.prnewswire.com/prnh/20100920/NY67927LOGO) "The addition of ...
... HILL, N.C., Feb. 14, 2011 Thought Leader Select, ... the biopharmaceutical industry and the medical community, announces the ... blog Marketing4Health . The research ... to become the blog,s exclusive sponsor, beginning ...
Cached Medicine Technology:Medical Devices and Diagnostics Analyst Joins MLV to Further Expand its Coverage of the Life Sciences Sector 2Thought Leader Select Announces Media Partnership with Marketing4Health 2
... Units With Titanium Staples for use with ... Titanium Staples)., ,The Auto Suture™ MULTIFIRE ... staplers with MULTIFIRE GIA™ 60 and 80 ... Suture™ MULTIFIRE SGIA™ 60 knifeless single use ...
... The PROXIMATE HCS Procedure for Prolapse and ... of titanium staples in 33mm diameter size. ... canal for transection and resection of internal ... surgical treatment of hemorrhoidal disease. The PPH01 ...
... ILS Staplers are anastomotic staplers available in ... instrument to lumen diameter. The staplers permit ... to improve access and ease of use. ... tissue compression by adjusting the height of ...
ENDOPATH ILS Circular Sizer Set for ILS circular staplers. , ,The ILS Circular Sizer Set is intended to aid in selecting the appropriate size ILS Intraluminal Stapler for use in a variety of applica...
Medicine Products: