Date:1/25/2011

hese cells is therefore of immense clinical interest. In this context, a team of researchers, led by Ying Qin Zang, at the Chinese Academy of Sciences, Shanghai, has now determined that the protein LXR negatively regulates the generation of both mouse and human Th17 cells. Importantly, LXR activation in mice ameliorated disease in a model of multiple sclerosis, whereas LXR deficiency exacerbated disease. Further analysis defined the signaling pathway underlying LXR-mediated regulation of Th17 cell generation. Thus, as highlighted by Liang Zhou and colleagues, at Northwestern University, Chicago, in an accompanying commentary, these data have important implications for those seeking to develop treatments for Th17 cellmediated autoimmune diseases.

TITLE: Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

AUTHOR CONTACT:
Ying Qin Zang
Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China.
Phone: 86.21.54920913; Fax: 86.21.54920913; E-mail: yqin@sibs.ac.cn.

View this article at: http://www.jci.org/articles/view/42974?key=fb9e07860b073ae41198

ACCOMPANYING COMMENTARY
TITLE: Nuclear receptors take center stage in Th17 cellmediated autoimmunity

AUTHOR CONTACT:
Liang Zhou
Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Phone: 312.503.3182; Fax: 312.503.8240; E-mail: L-Zhou@northwestern.edu.

View this article at: http://www.jci.org/articles/view/45939?key=37afc300bad910d99b5a

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ONCOLOGY: Stromal instigation promotes tumor growth

Critical to the growth and progression of a tumor is the aberrant fibrous tissue, which is know
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Contact: Ushma Neill press_releases@the-jci.org 734-546-5241 Journal of Clinical Investigation Source:Eurekalert

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