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JCI table of contents: Jan. 25, 2011
Date:1/25/2011

resembling erosive rheumatoid arthritis. Importantly, the disease was initiated by the GGTase-Ideficient macrophages, which hypersecreted inflammatory molecules known as cytokines. As the authors note and Mark Philips, at New York University, New York points out, in an accompanying commentary, these data have important implications for drug development, where GGTase-I inhibitors have been proposed as a strategy to treat inflammatory disorders and are under development as anticancer drugs.

TITLE: Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

AUTHOR CONTACT:
Martin O. Bergo
Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Phone: 46.31.342.78.58; Fax: 46.31.82.37.62; E-mail: martin.bergo@wlab.gu.se.

View this article at: http://www.jci.org/articles/view/43758?key=3a26ecf260de7bfbb5ca

ACCOMPANYING COMMENTARY
TITLE: The perplexing case of the geranylgeranyl transferasedeficient mouse

AUTHOR CONTACT:
Mark R. Philips
New York University Cancer Institute, New York, New York, USA.
Phone: 212.263.7404; Fax: 212.263.9210; E-mail: mark.philips@nyumc.org.

View this article at: http://www.jci.org/articles/view/45952?key=84050ca36dfb7be0c5e6


IMMUNOLOGY: More regulators of Th17 immune cell generation

A subset of immune cells known as Th17 cells have an important role in clearing certain bacterial and fungal infections. However, they are also thought to sometimes attack other cells and tissues of the body, causing autoimmune diseases such as multiple sclerosis. Understanding the regulatory pathways underlying the generation of t
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Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

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