JCI table of contents: Jan. 25, 2011 (enn.edu sryeom@upenn.edu . View this...)

JCI table of contents: Jan. 25, 2011

Date:1/25/2011

enn.edu">sryeom@upenn.edu.

View this article at: http://www.jci.org/articles/view/45976?key=0691d06bba3bde5fff57

CARDIOLOGY: Developmental misstep results in extremely fast heartbeat

Wolff-Parkinson-White syndrome is characterized by periods of an extremely fast heartbeat. These occur because of the presence of additional electrical pathways in the heart that cause the bottom chambers of the heart (the ventricles) to contract prematurely. The developmental reasons for premature ventricular contraction (also known as ventricular preexcitation) are not well understood. However, two independent research groups have now identified in mice a new mechanism by which additional electrical pathways in the heart can form, resulting in ventricular preexcitation. Specifically, the data from both groups one led by Jonathan Epstein, at the University of Pennsylvania, Philadelphia; and the other by Vincent Christoffels, at the Academic Medical Center, The Netherlands indicate that additional electrical pathways in the heart form as a result of inappropriate development of a structure in the embryonic heart known as the AV canal.

In an accompanying commentary, Hiroshi Akazawa and Issei Komuro, at the Osaka University Graduate School of Medicine, Japan, discuss the importance of these two papers for understanding the mechanisms of physiologic and pathologic heart development.

TITLE: Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways

AUTHOR CONTACT:
Jonathan A. Epstein
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: 215.898.8731; Fax: 215.573.2094; E-mail: epsteinj@mail.med.upenn.edu.

View this article at: http://www.
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Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

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