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JCI table of contents: Jan. 25, 2011
Date:1/25/2011

EDITOR'S PICK: Possible new approach to treating a life-threatening blood disorder

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease of the blood system. The condition is caused by the presence of ultralarge multimers of the protein von Willebrand factor, which promote the formation of blood clots (thrombi) in small blood vessels throughout the body. Current treatments are protracted and associated with complications. However, a team of researchers, led by Jos Lpez, at the Puget Sound Blood Center, Seattle, has generated data in mice that suggest that the drug N-acetylcysteine (NAC), which is FDA approved as a treatment for chronic obstructive lung disease and as an antidote for toxicity due to acetaminophen (paracetamol), might provide a rapid and effective treatment for patients with TTP through its ability to decrease the size of von Willebrand factor multimers.

In an accompanying commentary, Michael Berndt and Robert Andrews, concur with the conclusions of Lpez and colleagues, although they caution that there are a number of caveats to the view that NAC could be used to treat patents with TTP.

TITLE: N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice

AUTHOR CONTACT:
Jos A. Lpez
Puget Sound Blood Center, Seattle, Washington, USA.
Phone: 206.398.5930; Fax: 206.587.6056; E-mail: josel@psbcresearch.org.

View this article at: http://www.jci.org/articles/view/41062?key=f24412516a0e75fcdeae

ACCOMPANYING COMMENTARY
TITLE: Thrombotic thrombocytopenic purpura: reducing the risk?

AUTHOR CONTACT:
Michael C. Berndt
Dublin City University, and Royal College of Surgeons in Ireland, Dublin, Ireland.
Phone: 353.1.7007658; Fax: 353.1.7006558; E-mail:

Contact: Ushma Neill
press_releases@the-jci.org
734-546-5241
Journal of Clinical Investigation
Source:Eurekalert

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