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JCI table of contents: Jan. 24, 2008
Date:1/24/2008

he-jci.org/article.php?id=32899">https://www.the-jci.org/article.php?id=32899

ACCOMPANYING COMMENTARY TITLE: Can you hear me now? A genetic model of otitis media with effusion

AUTHOR CONTACT:
Evelyn Lazaridis
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: (215) 898-7504; Fax: (215) 898-7504; E-mail: elaz@mail.med.upenn.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33716


OPHTHALMOLOGY: I can see clearly now Epo has come and gone

Erythropoietin (Epo) is a hormone that stimulates red blood cell production and that is used to treat individuals who are anemic, including individuals who are anemic and have diseases of the eye caused by pathologic new blood vessel growth in the retina, such as diabetic retinopathy (DR) and retinopathy of prematurity. However, high levels of Epo have been found in the eye of individuals who are not anemic but who have DR, meaning that the relationship between Epo and retinopathies is not well defined. A new study by Lois Smith and her colleagues at Childrens Hospital, Boston, has now revealed a highly timing-dependent role for Epo in this disease process in mice.

Retinopathy occurs in two phases that are characterized by blood vessel loss and growth, respectively. In this study, Epo deficiency during early retinopathy was shown to contribute to retinal blood vessel loss in mice, and Epo treatment reduced this loss. In contrast, late Epo treatment exacerbated retinal disease by enhancing blood vessel growth. The authors have therefore recommended careful monitoring of Epo therapy in patients at risk for retinopathy, particularly diabetics. As early treatment with Epo also protected mice from retinal nerve cell death, Maria Grant and colleagues suggested in an accompanying commentary that Epo might p
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Journal of Clinical Investigation
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