Navigation Links
JCI table of contents: Jan. 24, 2008
Date:1/24/2008

stem/progenitor population in vivo is associated with enhanced bone regeneration in mice

AUTHOR CONTACT:
David T. Scadden
Massachusetts General Hospital, Boston, Massachusetts, USA.
Phone: (617) 726-5615; Fax: (617) 724-2662; E-mail: dscadden@mgh.harvard.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33102

ACCOMPANYING COMMENTARY TITLE: Bone building with bortezomib

AUTHOR CONTACT:
G. David Roodman
Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Phone: (412) 688-6571; Fax: (412) 688-6960; E-mail: roodmangd@upmc.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34734


NEUROBIOLOGY: Understanding a cause of Lou Gehrigs disease

Amyotrophic lateral sclerosis (ALS), often known as Lou Gehrigs disease, is the most common adult-onset motor neuron disease. Although most cases of ALS arise randomly, a sizeable proportion of individuals inherit the disease. Among these inherited cases, mutations in the SOD1 gene are the most frequently identified cause. A new study in mice, by John Engelhardt and colleagues at Iowa University, Iowa City, has identified a new mechanism by which SOD1 mutations associated with ALS can alter normal cellular function and trigger cell damage. As there is no known cure for ALS, the authors hope that these data might provide potential targets for the development of drugs to treat individuals with ALS caused by mutations in the SOD1 gene.

In the study, SOD1 was shown to regulate the production of the potentially dangerous oxygen radical superoxide by a protein known as Nox. In normal cells, SOD1 was found to bind and stabilize an activator of No
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. New Drug Application Submitted to FDA for Investigational Analgesic Tapentadol Immediate Release Tablets
2. China Nepstar Chain Drugstore Launches Charitable Initiative to Promote Awareness of Low-income Working Womens Health Issues
3. What is the more suitable for early detection of low abundant lamivudine-resistant mutants?
4. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic OTC Versions of Childrens Zyrtec(R) Chewable Tablets for Allergy Relief and Childrens Zyrtec(R) Chewable Tablets for Hives Relief
5. Ways to improve informed consent are testable, study says
6. JCI online early table of contents: Jan. 10 2008
7. Bayer Corporation Renames Its U.S. Foundation, Refocuses Charitable Giving Areas
8. Round Table Family Charities Raises $350,000 for Childrens Miracle Network
9. New study: US ranks last among other industrialized nations on preventable deaths
10. US ranks last among other industrialized nations on preventable deaths
11. Ambien CR(R) (zolpidem tartrate extended-release) tablets CIV Improved Chronic Insomnia in Patients with Co-Morbid Generalized Anxiety Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2015)... May 24, 2015 EnviroLeather™ by ... “InkGard™ Plus” – a classic, rugged leather grain ... allowing difficult stains, including ink, to be easily ... colors suitable for corporate, healthcare, hospitality and education ... with EnviroLeather’s goal of developing products that are ...
(Date:5/24/2015)... Viejo, CA (PRWEB) May 24, 2015 ProPin ... use in Final Cut Pro X. Utilize ProPin to pin ... in a given scene. , ProPin allows users to ... completely customizable in FCPX. With on-screen controls, video editors can ... allows users to pin and mark with absolute ease. , Using ...
(Date:5/24/2015)... Medicx Media Solutions http://www.medicxmedia.com ... Krihak as its head of programmatic strategy and ... expertise and leadership position in the data driven ... , Krihak is an experienced, award-winning agency and ... sales planning teams for mobile platform Jumptap. ...
(Date:5/24/2015)... 24, 2015 A report out ... the single best option for avoiding cardiovascular disease is ... level was the single most powerful predictor of death ... as diabetes and family history of premature death -- ... heart and lung fitness. , The Importance of Cardiovascular ...
(Date:5/23/2015)... D.C. (PRWEB) May 23, 2015 On ... of powers of a youngster's yogic power learned through ... Sri Nithyananda Swami in Bangalore, India. , Yogamaatha, a ... more than 50 high profile professionals attending the 2015 ... by reading fluently -- blindfolded. , In a ...
Breaking Medicine News(10 mins):Health News:EnviroLeather By LDI Launches "InkGard Plus" - Stain Resistant Faux Leather 2Health News:Developers at Pixel Film Studios Release ProPin for Final Cut Pro X. 2Health News:Medicx Media Solutions Expands Executive Team 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 3Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3
... 2009, Cambridge, UK ,Anyone with a sweet tooth knows ... negative consequences. The same can be said about the ... new study of myelin, a protein key to efficient neuronal ... much like the insulation on a cable, allows for rapid ...
... nanospheres equipped with a targeting peptide find melanoma cells, penetrate ... near-infrared light, a research team led by scientists at The ... the Feb. 1 issue of Clinical Cancer Research . ... grail of therapeutic nanotechnology for cancer. We,re getting closer to ...
... Knowing what to expect before and after procedure aids healing, ... With increasing numbers of baby boomers reaching retirement age, joint ... , But improved movement and lack of pain in ... to expect from the surgery and subsequent physical therapy can ...
... Total Health Center shows that our new Hgh product destroys fat cells ... , ... (PRWEB) February 1, 2009 -- Scientists at The Total Health and ... to destroy fat on men and women without dieting. Sources at the ...
... A study in the Feb. 1 issue of the ... levels that occurs during pregnancy is more pronounced in pregnant ... , During the last trimester of pregnancy, levels ... women with RLS and 25,475 pg/mL in healthy controls. ...
... A study in the Feb. 1 issue of the ... associated with changes in the levels of specific cytokines ... suggest that inflammation may be the pathway linking extreme ... Each additional hour of self-reported sleep duration was associated ...
Cached Medicine News:Health News:Targeted nanospheres find, penetrate, then fuel burning of melanoma 2Health News:Targeted nanospheres find, penetrate, then fuel burning of melanoma 3Health News:A Checklist for Joint Replacement Surgery 2Health News:Pregnancy-related hormonal changes linked to increased risk of restless legs syndrome 2Health News:Study suggests that inflammation may be the link between extreme sleep durations and poor health 2
(Date:5/22/2015)... ROCKVILLE, Md. , May 22, 2015 /PRNewswire/ ... "RegeneRx") today announced a peer-reviewed publication of the ... study evaluating RGN-259 (RegeneRx,s preservative-free eye drops) for ... Inc.,s controlled adverse environment (CAE ® ) model.  ... and the results, which were previously disseminated by ...
(Date:5/22/2015)... 2015   InspireMD, Inc. (NYSE MKT: NSPR) ("InspireMD" ... ("EPS"), today announced that its CGuard TM Embolic Prevention ... Prof. Piotr Musialek , at the EuroPCR ... . PARADIGM, an investigator-initiated P rospective ... roti D revascularization I n symptomatic and increased-risk ...
(Date:5/22/2015)... Richmond Pharmacology is a ... a worldwide reputation for excellence in clinical trials. ... peer reviewed medical journals. Its officers are engaged ... discussions about rules for transparency and publication of ... , Clinical research is conducted worldwide, ...
Breaking Medicine Technology:Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 2Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 3Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 4InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4
... Milestone Scientific Inc. (OTCQB: MLSS), the recognized leader in ... its 2010 year-end results for the 12 months ended ... Commission on Wednesday, March 30, 2011. Milestone,s ... 4, 2011 beginning at 4:15 PM Eastern Daylight Savings ...
... YORK, April 1, 2011 NeoStem, Inc. (NYSE Amex: ... company with operations in the U.S. and China, is today ... activities: Revenues for the year ended December ... 2009.  2010 was the first full year that results for ...
Cached Medicine Technology:Milestone Scientific Will Host Its 2011 Conference Call on Monday, April 4, 2011 2NeoStem Provides Results for 2010 and an Update on Recent Activities 2NeoStem Provides Results for 2010 and an Update on Recent Activities 3NeoStem Provides Results for 2010 and an Update on Recent Activities 4NeoStem Provides Results for 2010 and an Update on Recent Activities 5
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: