Navigation Links
JCI table of contents: Dec. 28, 2009
Date:12/28/2009

EDITOR'S PICK: 'Notch'ing up a role in the multisystem disease tuberous sclerosis complex

Two independent teams of researchers have identified a role for enhanced activation of the signaling protein Notch in tumors characterized by inactivation of either the TSC1 or the TSC2 protein. As indicated by Warren Pear, at the University of Pennsylvania, Philadelphia, in an accompanying commentary, these data provide a rationale for testing whether Notch inhibitors are of benefit to those with TSC-associated tumors.

Tuberous sclerosis complex (TSC) is a multisystem disease characterized by the formation of benign tumors in multiple organs. It is caused by mutations in either the TSC1 or TSC2 gene. In the first study, Elizabeth Petri Henske, at Brigham and Women's Hospital, Boston, and Fabrice Roegiers, at Fox Chase Cancer Center, Philadelphia, found evidence of Notch signaling pathway activation in human angiomyolipomas, benign kidney tumors often found in patients with TSC, and in an angiomyolipoma-derived cell line. Importantly, inhibition of Notch suppressed proliferation of TSC2-deficient rat cells in a xenograft model. These authors therefore conclude that TSC proteins regulate Notch activity and that Notch dysregulation may underlie some of the distinctive clinical and pathologic features of TSC.

Results presented in the second study, by Hongbing Zhang and colleagues, at the Chinese Academy of Medical Sciences and Peking Union Medical College, People's Republic of China, provide further evidence that TSC proteins regulate Notch activity and that Notch overactivity contributes to the tumorigenic potential of cells deficient in either TSC1 or TSC2.

TITLE: The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development

AUTHOR CONTACT:
Elizabeth Petri Henske
Brigham and Women's Hospital, Boston, Massachusetts, USA.
Phone: (6
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Ranbaxy Receives Tentative Approval to Manufacture and Market Galantamine Tablets on an Exclusive Basis
2. Schering-Plough/Merck Pharmaceuticals Announce FDA Filing Acceptance of New Drug Application for Loratadine/Montelukast Tablet
3. JCI table of contents: Sept. 4, 2007
4. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
5. Actavis Launches Carvedilol Tablets in the U.S.
6. Mylan Announces Final FDA Approval for Carvedilol Tablets
7. Ranbaxy Gains Approval to Manufacture and Market Carvedilol Tablets in the U.S. Market
8. Actavis Launches Amlodipine Tablets in the U.S.
9. Implantable device designed to detect, stop seizures under study at MCG
10. Stevens Health, Technology and Society roundtable: Sept. 19
11. Fruity vegetables and fish reduce asthma and allergies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... (PRWEB) August 29, 2014 ALS, more commonly ... that damages the motor neurons in the brain and spinal ... the nerve cells controlling movement are harmed, which causes the ... this leads to death. , ALS is a disease that ... as many as 30,000 Americans have the disease at any ...
(Date:8/29/2014)... Canadian Healthy Vending , the largest ... annual survey of its 200 operators from every region ... that appeal to Canadian consumer seeking refreshment at healthy ... top five selling healthy snacks and top five selling ... issue for consumers, employers, and families. Everyone wants to ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Until now, ... (relational tables) or unstructured data (document stores). SQL products ... products have basically managed the wide assortment of unstructured ... to work with Big Data is with a NoSQL ... the various aspects of all Big Data issues. ...
(Date:8/28/2014)... August 29, 2014 VPS (Virtual ... physical server computer into many servers, each of ... on someone’s own dedicated computer. Top10BestSEOHosting.com has recently ... that GoDaddy ( http://www.top10bestseohosting.com/go/GoDaddy.com/ ), Bluehost and IX ... in 2014. , The IT manager of Top10BestSEOHosting.com ...
(Date:8/28/2014)... York (PRWEB) August 29, 2014 New ... they will be traveling around the country to Log ... final show in November. The New Energy Works team ... their timber frame design and build expertise, project images, ... Drake Ambrosino , New Energy Works’ Mid-West Representative, will ...
Breaking Medicine News(10 mins):Health News:Charity Event to Raise Awareness and Donations for the ALS Foundation 2Health News:Survey Results: What Products Do Canadians Want in Their Healthy Vending Machines? 2Health News:Survey Results: What Products Do Canadians Want in Their Healthy Vending Machines? 3Health News:Scientel Announces Support for SQL Queries and Relational Tables Within Its Gensonix® NoSQL DB 2Health News:Scientel Announces Support for SQL Queries and Relational Tables Within Its Gensonix® NoSQL DB 3Health News:Scientel Announces Support for SQL Queries and Relational Tables Within Its Gensonix® NoSQL DB 4Health News:Top10BestSEOHosting.com Announces The Best Three VPS Hosting Suppliers 2Health News:New Energy Works Timberframers Prepares to Exhibit Timber Framing at Autumn Trade Shows 2Health News:New Energy Works Timberframers Prepares to Exhibit Timber Framing at Autumn Trade Shows 3
... In January, victorious,politicians will go to work on America,s ... patients don,t have to wait on their elected,officials to ... give,feedback directly to their doctors, according to patient satisfaction ... "We don,t know whether politicians listen to their ...
... Nov. 24 After diabetes and hypertension,renal artery stenosis ... the opinions of nephrologists and cardiologists, as well as ... to screen for it. , ... cerebrovascular,cardiac, and peripheral arterial disease increases the frequency of ...
... 24 These days, many are feeling,financially, emotionally and ... under your eyes. Feeling spiritual seems the farthest thing,from ... smartphones, and online social,networking sites, we remain connected 24/7, ... mentally and physically is the new ,old, trend?,Join the ...
... job seekers find each other easier, Fresho.com becomes a job search engine ... ... (PRWEB) November 24, 2008 -- Due to the current economic woes, employment ... searches. To cope with the increasing demand for new job openings, Fresho ...
... of the elderly, the golden years are anything but. ... a spouse or loved one, many adults 65 years and ... help this group understand and treat the problem, another group ... , "Centenarians are still rare, and depression hasn,t been studied ...
... Shows Network Evening News and Newspapers Devote More Coverage to ... , , Health Was the ... Primary Season , , WASHINGTON, ... period of upheaval and transformation, a study from the Kaiser ...
Cached Medicine News:Health News:Politicians May Not Listen ... But Doctors Do, Says DrScore 2Health News:When Is Screening for Renal Artery Stenosis Medically Necessary? 2Health News:Engaging In Life with One Spirit Book Club 2Health News:Fresho.com Adapts As The Online Recruiting Market Heats Up 2Health News:Bittersweet milestones 2Health News:Wide-Ranging Study of National News Reveals Health News Comprises Less Than Four Percent of All Coverage 2Health News:Wide-Ranging Study of National News Reveals Health News Comprises Less Than Four Percent of All Coverage 3Health News:Wide-Ranging Study of National News Reveals Health News Comprises Less Than Four Percent of All Coverage 4
(Date:8/28/2014)... Aug. 28, 2014 Levi & Korsinsky announces ... the United States District Court for the District of ... who purchased Galectin Therapeutics Inc. ("Galectin" or the "Company") ... 28, 2014. For more information, click here: ... during the Class Period the Company violated federal securities ...
(Date:8/28/2014)... , August 28, 2014 ... titled, "DNA diagnostics Market (products, applications, techniques, end ... Opportunities, Growth and Forecast, 2013 - 2020," indicates ... $19 billion by 2020 registering a CAGR of ... provide accurate diagnosis and cost effectiveness over alternative ...
(Date:8/28/2014)... Aug. 28, 2014 /PRNewswire-iReach/ -- Gateway Analytical announced ... 9 th Annual Global Pharma Manufacturing Summit ... 8-9 th . The Global Pharma Manufacturing Summit ... small molecule and biologic pharmaceutical manufacturing. The conference ... today,s manufacturers face, such as the increasing pressure ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Levi & Korsinsky, LLP Reminds Investors of Class Action Against Galectin Therapeutics Inc. and Its Board of Directors and a Lead Plaintiff Deadline of September 29, 2014 -- GALT 2DNA Diagnostics Market is Expected to Reach $19 Billion by 2020 - Allied Market Research 2DNA Diagnostics Market is Expected to Reach $19 Billion by 2020 - Allied Market Research 3Gateway Analytical to Promote Particulate Identification Services at the 9th Annual Global Pharma Manufacturing Summit 2Gateway Analytical to Promote Particulate Identification Services at the 9th Annual Global Pharma Manufacturing Summit 3
... -- China Health Resource, Inc. (OTCBB: CHRI), today announced results ... the first quarter of 2012. Revenues for ... increase of 234% over revenues of US $10,282,207 for 2010. For ... common share, compared with a net income of $2,707,286, or ...
... Oncos Therapeutics today announced the successful initiation ... adenovirus suggested as a potential new treatment for many types ... safety assessment part of the study. " We ... r thern Europe to start a clinical study with ...
Cached Medicine Technology:China Health Resource Reports on Record Year-End 2011 Results Continuing Strong in 2012 2China Health Resource Reports on Record Year-End 2011 Results Continuing Strong in 2012 3Oncos Therapeutics Initiates Phase I Clinical Study of CGTG-102, an Oncolytic Adenovirus for the Treatment of Solid Tumor Cancers 2
... research model of the Bowman Perfusion Monitor ... continuously in real-time. This precision instrument activates ... which is connected by an umbilical cord ... digital form and send the data to ...
Housed in a small lightweight, flame retardant plastic cases, meters are equipped with a convenient multiposition handle/stand. Measure microcirculation in 1 cubic mm of tissue for real-time assessme...
... featured laser doppler system for continuous ... multiple tissue sites. This latest generation ... Processing (DSP) and laser Doppler flowmetry ... to use, multi-channel monitor, setting new ...
Transcranial vascular DWL doppler....
Medicine Products: