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JCI table of contents: Dec. 22, 2010
Date:12/22/2010

AR makes sense

Individuals who die from bladder cancer do so predominantly because their tumor has spread to (metastasized to) another site, often the lungs. The protein ET-1 has been implicated in this process. As a result, therapeutics targeting the molecule to which ET-1 binds (ETAR) are being developed and tested in the clinic. Now, a team of researchers, working primarily at the University of Virginia, Charlottesville, has determined that these agents should be tested as adjuvant therapeutic agents, rather than as initial treatment for primary or metastatic disease, if they are to succeed in the clinic. Several lines of evidence led the team, which was headed by Dan Theodorescu, to this conclusion. In particular, the observation that tumor expression of ET-1 and ETAR was necessary for human and mouse cancer cell metastasis to the mouse lung but was less important for the growth of established primary and metastatic tumors.

TITLE: Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer

AUTHOR CONTACT:
Dan Theodorescu
University of Colorado, Aurora, Colorado, USA.
Phone: 303.724.7135; Fax: 303.724.3162; E-mail: dan.theodorescu@ucdenver.edu.

View this article at: http://www.jci.org/articles/view/42912?key=2683fab420b3d4fa6359


VIROLOGY: Predicting who will not respond to treatment for hepatitis C virus

Most people who become infected with hepatitis C virus (HCV) fail to clear the virus from their body and become chronically infected. Current treatment for chronic HCV infection is effective in only about half of those that receive it. Recent data indicate that high levels of the molecule CXCL10, which helps attract immune cells to sites of infection, in the blood of an HCV-infected patient forecast a
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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