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JCI table of contents: Dec. 22, 2010
Date:12/22/2010

ining the blood vessels of the brain and cells of the tumor. As further analysis indicated that primary human gliomas express TfR, the authors hope that their approach can be translated to the clinic for the targeted detection and treatment of brain tumors.

In an accompanying commentary, Paul Mischel and David Nathanson, at the University of California, Los Angeles, discuss both the importance of these data for developing new approaches to treating brain tumors and the potential for this approach to be applied to the discovery of new druggable targets for other forms of cancer.

TITLE: Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma

AUTHOR CONTACT:
Renata Pasqualini
The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Phone: 713.792.3872; Fax: 713.745.2999; E-mail: rpasqual@mdanderson.org.

Wadih Arap
The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Phone: 713.792.3872; Fax: 713.745.2999; E-mail: warap@mdanderson.org.

View this article at: http://www.jci.org/articles/view/44798?key=5d899f946725c22b5f81

ACCOMPANYING COMMENTARY
TITLE: Charting the course across the blood-brain barrier

AUTHOR CONTACT:
Paul S. Mischel
David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Phone: 310.794.5223; Fax: 310.206.8290; E-mail: pmischel@mednet.ucla.edu.

View this article at: http://www.jci.org/articles/view/45758?key=7acf1d3d30e1e9039d10


ONCOLOGY: Adjuvant use of anti-cancer drug targeting the protein ET
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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