TITLE: Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
Georgetown University Medical Center, Washington, DC, USA.
Phone: 202.687.9504; Fax: 202.687.1434; E-mail: email@example.com.
View this article at: http://www.jci.org/articles/view/42874?key=b4953e0cf3401fb57e38
TITLE: Arsenic: a potentially useful poison for Hedgehog-driven cancers
G. Praveen Raju
Weill Cornell Medical College, New York, New York, USA.
Phone: 212.746.1279; Fax: 212.746.4001; E-mail: firstname.lastname@example.org.
View this article at: http://www.jci.org/articles/view/45692?key=d168085cd96838efb43b
ONCOLOGY: Gaining access to the brain to destroy brain tumors
A major obstacle to developing new approaches to treating brain tumors is the almost impenetrable blood-brain barrier, which, as its name suggests, shelters the brain from the general blood supply to the body. However, a team of researchers, led by Renata Pasqualini and Wadih Arap, at the University of Texas M.D. Anderson Cancer Center, Houston, has now developed an approach that allowed them to deliver therapeutic cargo and molecular imaging reporters across the blood-brain barrier in an intracranial mouse model of glioblastoma, one of the most lethal of all cancers. The approach relied on expression of the protein TfR by both cells l
|Contact: Karen Honey|
Journal of Clinical Investigation