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JCI table of contents: Dec. 22, 2010
Date:12/22/2010

arcoma and medulloblastoma are predominantly tumors of childhood and the Hh pathway is crucial for both embryonic and postnatal development, so ATO inhibition of this pathway might have severe side effects in such patients.

TITLE: Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

AUTHOR CONTACT:
Aykut ren
Georgetown University Medical Center, Washington, DC, USA.
Phone: 202.687.9504; Fax: 202.687.1434; E-mail: au26@georgetown.edu.

View this article at: http://www.jci.org/articles/view/42874?key=b4953e0cf3401fb57e38

ACCOMPANYING COMMENTARY
TITLE: Arsenic: a potentially useful poison for Hedgehog-driven cancers

AUTHOR CONTACT:
G. Praveen Raju
Weill Cornell Medical College, New York, New York, USA.
Phone: 212.746.1279; Fax: 212.746.4001; E-mail: prr9001@med.cornell.edu.

View this article at: http://www.jci.org/articles/view/45692?key=d168085cd96838efb43b


ONCOLOGY: Gaining access to the brain to destroy brain tumors

A major obstacle to developing new approaches to treating brain tumors is the almost impenetrable blood-brain barrier, which, as its name suggests, shelters the brain from the general blood supply to the body. However, a team of researchers, led by Renata Pasqualini and Wadih Arap, at the University of Texas M.D. Anderson Cancer Center, Houston, has now developed an approach that allowed them to deliver therapeutic cargo and molecular imaging reporters across the blood-brain barrier in an intracranial mouse model of glioblastoma, one of the most lethal of all cancers. The approach relied on expression of the protein TfR by both cells l
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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