Navigation Links
JCI table of contents: Dec. 20, 2007
Date:12/20/2007

EDITOR'S PICK: You can teach an old dog new tricks: antimalarial prevents cancer in mice

New data generated by a team of researchers from St Jude Childrens Research Hospital, Memphis, and Scripps Research Institute, Jupiter, have indicated that the antimalarial drug chloroquine effectively prevents cancer in mouse models of two distinct human cancer syndromes, Burkitt lymphoma and ataxia telangiectasia. As discussed in the accompanying commentary by Chi Dang, from Johns Hopkins University School of Medicine, Baltimore, these results complement an old epidemiology study suggesting that malarial prophylaxis with chloroquine diminished the incidence of Burkitt lymphoma.

In the study, chloroquine was shown to inhibit the development of Myc-induced lymphomas (a mouse model of Burkitt lymphoma) and to inhibit the development of lymphomas in ATM-deficient mice (a mouse model of ataxia telangiectasia). By contrast, chloroquine did not inhibit the development of lymphomas in p53-deficient mice. Further analysis indicated that chloroquine induced cellular features of autophagy (self-eating) and mediated its effects by inducing lysosomal stress and provoking a p53-dependent cell death. The authors therefore suggested that modulating autophagy, either using chloroquine or other approaches, might provide a new avenue for the development of anticancer therapeutics.

TITLE: Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

AUTHOR CONTACT:
Michael B. Kastan
St. Jude Childrens Research Hospital, Memphis, Tennessee, USA.
Phone: (901) 495-3968; Fax: (901) 495-3966; E-mail: michael.kastan@stjude.org.

John L. Cleveland
The Scripps Research Institute, Jupiter, Florida, USA.
Phone: (561) 799-8808; E-mail: jcleve@scripps.edu.

View the PDF of this article
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Ranbaxy Receives Tentative Approval to Manufacture and Market Galantamine Tablets on an Exclusive Basis
2. Schering-Plough/Merck Pharmaceuticals Announce FDA Filing Acceptance of New Drug Application for Loratadine/Montelukast Tablet
3. JCI table of contents: Sept. 4, 2007
4. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
5. Actavis Launches Carvedilol Tablets in the U.S.
6. Mylan Announces Final FDA Approval for Carvedilol Tablets
7. Ranbaxy Gains Approval to Manufacture and Market Carvedilol Tablets in the U.S. Market
8. Actavis Launches Amlodipine Tablets in the U.S.
9. Implantable device designed to detect, stop seizures under study at MCG
10. Stevens Health, Technology and Society roundtable: Sept. 19
11. Fruity vegetables and fish reduce asthma and allergies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... KY (PRWEB) , ... September 02, 2015 , ... Ericson ... the CDI Education Director for HCPro and Associate Director of Education for the Association ... CDI, Advancing CDI and ICD-10 for CDI Boot Camps. She serves as a CDI ...
(Date:9/2/2015)... ... September 02, 2015 , ... The 2015 China Overseas ... investment and business conference will be hosted at five star Beijing Kunlun Hotel ... networking conference will feature leading EB-5 industry professionals and Chinese private equity partners ...
(Date:9/2/2015)... Minneapolis, MN (PRWEB) , ... September 02, 2015 ... ... is commercializing products for the upper extremity surgical market, announced today that more ... instrument for trigger releases in the hand. Plus, nearly 70 of these ...
(Date:9/2/2015)... (PRWEB) , ... September 02, 2015 , ... On September ... to attend doTERRA’s annual convention, the largest single-company convention to date for the state ... and look forward to a tremendous event,” states David Stirling, doTERRA CEO. “One of ...
(Date:9/2/2015)... ... September 02, 2015 , ... The payroll conference ... days of payroll education covering legislative updates, including unemployment, global payroll best practices, ... representatives from Ceridian, Ultimate Software, the American Payroll Association, Barnett Associates, and the ...
Breaking Medicine News(10 mins):Health News:ezDI Names Noted CDI Educator Cheryl Ericson as Company’s Clinical Documentation Manager 2Health News:ezDI Names Noted CDI Educator Cheryl Ericson as Company’s Clinical Documentation Manager 3Health News:ezDI Names Noted CDI Educator Cheryl Ericson as Company’s Clinical Documentation Manager 4Health News:The 2015 China Overseas Investment and Entrepreneurship Summit (COIES) Announced 2Health News:Trigger Tome Surpasses 600 Successful Patient Procedures 2Health News:doTERRA to Host the Largest Single-Company Convention in the State of Utah 2Health News:23rd Annual NJ Statewide Payroll Conference in Vernon, NJ at the Minerals Hotel on October 15-16, 2015 2
... indeed a ‘ubiquitous’ festival, as it is celebrated throughout the ... 26 million Indian homes.// The joys of the season is ... making the most of the special bargains and discounts of ... the celebration. Plans are afoot in great enthusiasm as homes ...
... The surprising structure and properties of a protein responsible for ... it binds its target RNA// -- are described by researchers ... is an essential nutrient, and defects in uptake and metabolism ... a variety of diseases and disorders, including heart disease, arthritis ...
... Agricultural Research Service (ARS) funded research suggest that berry extracts ... found that laboratory animals, which were fed berry extracts and ... damage to brain function. ,Three groups ... for about three months. The control group was fed a ...
... Health plans, school girls as young as 12 could ... cause cervical cancer//. Researchers have found that the Human ... of cervical cancer, which kills around 1,000 women a ... the human papilloma virus (HPV) before they become sexually ...
... (AL) on Saturday voiced concern on the developments regarding the ... Libyan children with the HIV/AIDS virus//. AL also issued an ... ,The AL also expressed full sympathy underlining the ... order to curb the consequences of this "painful human catastrophe". ...
... (FDA) is expected to announce soon the results of its ... some species of cloned animals. ,Two experts ... Agriculture Policy are available to media to comment on the ... safety of consuming meat and milk from cloned animals. ...
Cached Medicine News:Health News:Come Apart and Rest Awhile – It’s Christma 2Health News:Come Apart and Rest Awhile – It’s Christma 3Health News:Structure of Iron Regulatory Protein-RNA Complex Solved 2
(Date:9/2/2015)... , Sept. 2, 2015 Research ... addition of the "Medical Device Studies: Clinical ... conference to their offering. This ... are involved in gathering clinical evidence required for ... is required for all medical devices and the ...
(Date:9/2/2015)... , Sept. 2, 2015 Research and Markets ... "New EU Pharmacovigilance Legislation (London, UK - November ... The 15 new EU modules concerning Pharmacovigilance are ... is conducted in Europe . The ... modules and their requirements, examine how they overlap and ...
(Date:9/2/2015)... , Sept. 2, 2015 Demers Ambulances is ... Inc. as their new dealer for the states of ... Tennessee . "This will ... said Benoit Lafortune , Executive Vice-President for Demers Ambulances. ... Mississippi and Alabama , ...
Breaking Medicine Technology:Medical Device Studies: Clinical Evidence Course - London, UK - November 10-11, 2015 2Demers Ambulances has named Emergency Equipment Professionals (EEP) Inc. as their dealer for the states of MS, AL and TN 2
... GSK ) today announced that the United ... for PROMACTA® (eltrombopag), an oral tablet that can raise ... chronic immune (idiopathic) thrombocytopenic purpura (ITP) who have had ... PROMACTA initially received FDA orphan drug designation ...
... Therapeutics LLC ("Deston") announced today that it is currently exploring ... Auralgan Otic Solution ("Auralgan") by the Federal Government and that ... drug product. "Despite the recent actions by ... and effective treatment for ear pain and inflammation," said David ...
Cached Medicine Technology:FDA Grants Full Approval for PROMACTA® (eltrombopag) for Treatment of Rare Blood Disorder 2FDA Grants Full Approval for PROMACTA® (eltrombopag) for Treatment of Rare Blood Disorder 3FDA Grants Full Approval for PROMACTA® (eltrombopag) for Treatment of Rare Blood Disorder 4Deston Therapeutics Stands By Safety and Efficacy of Auralgan After FDA Action 2Deston Therapeutics Stands By Safety and Efficacy of Auralgan After FDA Action 3Deston Therapeutics Stands By Safety and Efficacy of Auralgan After FDA Action 4
... Vascular Graft, the newest vascular graft offering ... leader in vascular surgical products for more ... reducing kinking and compression problems that ... graft provides all of the benefits of ...
... rasping necessary in cruciate ligament reconstruction procedures ... bone surface. This condition, if not rectified ... cruciate replacement. The GORE SMOOTHER Crucial Tool ... procedures. The tool functions as both a ...
Vikingselect™ Intra-Operative Monitoring (IOM)....
... system has been designed by practicing ... of the ever changing and demanding ... analyzing data from multiple modalities, including: ... and multiple patients at multiple sites. ...
Medicine Products: