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JCI table of contents: April 25, 2011

en doors for further investigation.

TITLE: Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations

Andrzej A. Dlugosz
University of Michigan Medical School, Ann Arbor, Michigan, USA.
Phone: 734.647.9482; Fax: 734.763.4575; E-mail:

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TITLE: Mommy where do tumors come from?

Ervin H. Epstein Jr.
Children's Hospital of Oakland Research Institute, Oakland, California, USA.
Phone: 510.502.6144; Fax: 510.597.7096; E-mail:

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INFLAMMATION: New role for energy generators in controlling inflammation

The inflammatory response is initiated as a protective response but if the response is sustained or excessive it leads to tissue damage. A team of researchers, led by Jahar Bhattacharya, at Columbia University College of Physicians and Surgeons, New York, has now identified in mice a new molecular mechanism that curbs excessive inflammation. Specifically, the team found that mitochondria (the energy generating compartments of a cell) in cells lining blood vessels in the lungs are key regulators of inflammation. As highlighted by both the authors and, in an accompanying commentary, Laura A. Dada and Jacob I. Sznajder, these data provide potential new therapeutic targets for the treatment of the deleterious effects of the inflammatory response.

TITLE: Activation of TNFR1 ectodomain shedding by mitochondr

Contact: Karen Honey
Journal of Clinical Investigation

Page: 1 2 3 4 5 6

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