Navigation Links
JCI table of contents: April 25, 2011
Date:4/25/2011

">http://www.jci.org/articles/view/45666?key=e1fa320bcbef4924b014

ACCOMPANYING COMMENTARY
TITLE: MMPs in tuberculosis: granuloma creators and tissue destroyers

AUTHOR CONTACT:
Padmini Salgame
University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA.
Phone: 973.972.8647; Fax: 973.972.0713; E-mail: salgampa@umdnj.edu.

View this article at: http://www.jci.org/articles/view/57423?key=3b7d5c2835bb456b9eab


ONCOLOGY: On the origin of the tumor

It is, in general, very hard to cure a cancer once it has become clinically apparent. By identifying the cells from which a cancer arises researchers hope that it might be possible to detect cancerous lesions at much earlier stages and treat them more successfully. With this in mind, Andrzej Dlugosz and colleagues, at the University of Michigan Medical School, Ann Arbor, have now identified in mice the cells from which two forms of basal cell carcinoma arise.

Basal cell carcinomas are the most common human cancers. Although uncontrolled Hedgehog signaling drives almost all basal cell carcinomas, it is not clear why they differ in appearance and can be divided into different types. In this study, Dlugosz and colleagues used engineered mouse models of basal cell carcinoma to determine that superficial basal cell carcinomalike tumors arise from interfollicular epidermis and nodular basal cell carcinomalike tumors from hair follicle stem cells, thereby generating data that indicate that the cell of origin influences the type of basal cell carcinoma that develops.

In an accompanying commentary, Ervin Epstein Jr., at Children's Hospital of Oakland Research Institute, Oakland, discusses how these data fit with other recent studies on the origin of basal cell carcinomas and op
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. JCI online early table of contents: April 18, 2011
2. Accountable care organizations have potential to curb costs and improve health care
3. JCI online early table of contents: April 11, 2011
4. Wiley hosts developmental psychology roundtable at SRCD
5. Implantable Device May Lower Tough-to-Treat Hypertension
6. JCI online early table of contents: April 1, 2011
7. Tetanus Still Diagnosed in U.S., Although Its Preventable
8. JCI online early table of contents: March 23, 2011
9. DSF Charitable Foundation gives $3.9M to CMUs Center or Nucleic Acids Science & Technology
10. Gardening linked to increased vegetable consumption in older adults
11. JCI online early table of contents: March 14, 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... , ... August 01, 2015 , ... Super Bowl 50 will emanate from ... League’s biggest day each year is the Super Bowl. In the two weeks that separate ... from the host venue. The 2016 Super Bowl game will mark the 50th time it ...
(Date:7/31/2015)... ... July 31, 2015 , ... Precision Aesthetics is New York’s only ... was also the first provider of Exilis non-surgical fat reduction in New York. ... has attracted a large International clientele. Many patients travel to New York to ...
(Date:7/31/2015)... , ... July 31, 2015 , ... ... new store run by GoodThreads. The store can be accessed by visiting ... many of which are customizable. The best part: whenever a product is purchased, ...
(Date:7/31/2015)... ... 31, 2015 , ... Sculpted Contours Luxury Medical Aesthetics announces the arrival of ... Aesthetics released this new applicator in the United States as an upgrade to the ... The original applicator required a 2 hour treatment time. The new CoolSmooth ...
(Date:7/31/2015)... ... 2015 , ... Jacksonville-based drug and alcohol rehabilitation center, Lakeview ... The medical community, social workers, law enforcement, and government officials are all invited ... effort to better understand and combat sex trafficking. Lead by sex trafficking expert ...
Breaking Medicine News(10 mins):Health News:Cheap 2016 Super Bowl Tickets at Levi's Stadium: Ticket Down Slashes Ticket Prices on Super Bowl 50 Tickets in Santa Clara, CA at Levi's Stadium 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 2Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 3Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3
... percent have or want to have a wellness program with a ... universal ... health care -, ... nation,s leading employee benefits advisory,organizations, today announced key findings from its ...
... achievements at April 22 reception, WASHINGTON, April ... (NASWF) is proud to present,William C. Bell, MSW, ... the,2007 International Rhoda G. Sarnat Award., The ... an individual,group, or organization that has significantly advanced ...
... been successfully treated for their disease face the ... testicular) tissue is transplanted back into their bodies ... university hospitals in Israel. , Writing in Europes ... 22 April), the researchers say that hundreds of ...
... University of Texas M. D. Anderson Cancer Center, mammography, ... has shown to significantly reduce the risk of being ... the age of 80, an age group currently without ... study, published online today (April 21) in the Journal ...
... Roush Fenway Racing;,Launches New Interactive Web site at redcrossracing.com, ... announced the launch of Red Cross Racing, a new ... raise awareness of the need to give,blood. Every two ... http://www.newscom.com/cgi-bin/prnh/20080421/DC20034 ), Through the support of 3M ...
... Underwriters, Inc. (Darwin) (NYSE: DR ) today ... 2008 financial results on Monday,April 28, 2008. The ... financial results will be conducted on Monday, April ... http://www.newscom.com/cgi-bin/prnh/20060829/NETU014LOGO ), The live webcast ...
Cached Medicine News:Health News:Survey: Employers Have High Confidence They Can Control Health Care Costs With Proper Tools 2Health News:Survey: Employers Have High Confidence They Can Control Health Care Costs With Proper Tools 3Health News:Social Workers Honor William C. Bell with the International Rhoda G. Sarnat Award 2Health News:Social Workers Honor William C. Bell with the International Rhoda G. Sarnat Award 3Health News:Cancer could return unless stored ovarian tissue undergoes adequate testing before re-implantation 2Health News:Cancer could return unless stored ovarian tissue undergoes adequate testing before re-implantation 3Health News:Mammography may be beneficial to all women, regardless of age 2Health News:Mammography may be beneficial to all women, regardless of age 3Health News:American Red Cross Launches National Campaign to Connect NASCAR Fans With Blood Donations 2Health News:American Red Cross Launches National Campaign to Connect NASCAR Fans With Blood Donations 3Health News:Darwin to Announce First Quarter 2008 Financial Results 2
(Date:7/31/2015)... , July 31, 2015  Xcelience, a contract ... it has made a structured cash investment in ... specializing in milling, micronization and powder size classification ... grow Powdersize,s business while simultaneously adding a complete ... portfolio of capabilities. "As we ...
(Date:7/31/2015)... 31, 2015 Egalet Corporation (Nasdaq: ... company focused on developing, manufacturing and marketing innovative ... previously announced underwritten public offering of 7,666,667 shares ... price of $11.25 per share. The shares of ... issued upon the exercise in full by the ...
(Date:7/31/2015)... SAN DIEGO , July 31, 2015 /PRNewswire/ ... Co., Ltd. (Headquarters: Tokyo , President ... Therapeutics, Inc. (Headquarters: San Diego, California ... "NASDAQ: HALO") have signed a clinical collaboration agreement to ... "eribulin") in combination with Halozyme,s investigational drug PEGPH20 (PEGylated ...
Breaking Medicine Technology:Xcelience Makes Structured Cash Investment in Powdersize 2Xcelience Makes Structured Cash Investment in Powdersize 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 2Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 5Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 6
... NEW YORK, April 13, 2012  Dr. David Samadi, leading ... prostate cancer survivors , and their families at the ... and detailed look at prostate cancer today, Dr. ... Robotic Technique) Surgery is so successful in treating the ...
... MIAMI BEACH, Fla., April 13, 2012  At the ... Scientific Meeting, April 14-18, at the Miami Beach ... innovations for Leksell Gamma Knife® Perfexion™ ... "Once again, AANS will give us the opportunity ...
Cached Medicine Technology:RoboticOncology.com News: SMARTer Prostate Cancer Treatment 2RoboticOncology.com News: SMARTer Prostate Cancer Treatment 3RoboticOncology.com News: SMARTer Prostate Cancer Treatment 4RoboticOncology.com News: SMARTer Prostate Cancer Treatment 5Elekta to Unveil New Neuroscience Solution for Leksell Gamma Knife at 2012 AANS Meeting 2
This multiple-function instrument allows the surgeon to grasp, coagulate, and transect tissue with a single instrument, eliminating the need for multiple instruments and, in some procedures, costly l...
Bipolar forceps...
... An in vitro Nucleic Acid ... using Microplate Chemiluminescence for the ... (HPV) Types 6,11,16,18,31,33,35,39,42,43,44,45,51,52,56,58,59 and 68 ... Lowand High-Risk Groups in Cervical ...
... superb radiation protection-0.62mm (+/- .05)Pb lead glass ... to their level of protection, they are ... smoothly on your bridge while hugging your ... wear corrective lenses, you can order Leaded ...
Medicine Products: