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JCI table of contents: April 25, 2011
Date:4/25/2011

">http://www.jci.org/articles/view/45666?key=e1fa320bcbef4924b014

ACCOMPANYING COMMENTARY
TITLE: MMPs in tuberculosis: granuloma creators and tissue destroyers

AUTHOR CONTACT:
Padmini Salgame
University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA.
Phone: 973.972.8647; Fax: 973.972.0713; E-mail: salgampa@umdnj.edu.

View this article at: http://www.jci.org/articles/view/57423?key=3b7d5c2835bb456b9eab


ONCOLOGY: On the origin of the tumor

It is, in general, very hard to cure a cancer once it has become clinically apparent. By identifying the cells from which a cancer arises researchers hope that it might be possible to detect cancerous lesions at much earlier stages and treat them more successfully. With this in mind, Andrzej Dlugosz and colleagues, at the University of Michigan Medical School, Ann Arbor, have now identified in mice the cells from which two forms of basal cell carcinoma arise.

Basal cell carcinomas are the most common human cancers. Although uncontrolled Hedgehog signaling drives almost all basal cell carcinomas, it is not clear why they differ in appearance and can be divided into different types. In this study, Dlugosz and colleagues used engineered mouse models of basal cell carcinoma to determine that superficial basal cell carcinomalike tumors arise from interfollicular epidermis and nodular basal cell carcinomalike tumors from hair follicle stem cells, thereby generating data that indicate that the cell of origin influences the type of basal cell carcinoma that develops.

In an accompanying commentary, Ervin Epstein Jr., at Children's Hospital of Oakland Research Institute, Oakland, discusses how these data fit with other recent studies on the origin of basal cell carcinomas and op
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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