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JCI table of contents: April 25, 2011
Date:4/25/2011

45636?key=c7a74618d3a706d6e2a5

ACCOMPANYING COMMENTARY
TITLE: Fibulin-5: two for the price of one maintaining pelvic support

AUTHOR CONTACT:
Gina M. Northington
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Phone: 215.662.6361; Fax: 215.662.7929; E-mail: gnorthington@obgyn.upenn.edu.

View this article at: http://www.jci.org/articles/view/57438?key=dab0f15181873ab2fbf9

INFECTIOUS DISEASE: Targeting tissue destruction in tuberculosis

Infection with the bacterium Mycobacterium tuberculosis can cause tuberculosis. In most people, however, the bacteria do not cause disease but are sequestered in the lung in walled off compartments known as granulomas. By studying both human samples and mice expressing the human form of the protein MMP-1, a team of researchers, led by Paul Elkington, at Imperial College London, United Kingdom, has now generated data indicating that MMP-1 drives lung tissue destruction in granulomas. The team therefore suggests that targeting MMP-1 might provide a way to limit the damage caused by infection with Mycobacterium tuberculosis. This and other data indicating that MMPs represent viable therapeutic targets to control Mycobacterium tuberculosis infections are discussed in an accompanying commentary by Padmini Salgame, at the University of Medicine and Dentistry of New Jersey, Newark.

TITLE: MMP-1 drives immunopathology in human tuberculosis and transgenic mice

AUTHOR CONTACT:
Paul Elkington
Imperial College London, London, United Kingdom.
Phone: +44.20.8383.2733; Fax: +44.20.8383.3394; E-mail: p.elkington@imperial.ac.uk.

View this article at:

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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