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JCI online early table of contents: September 26, 2011
Date:9/26/2011

laser
Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Phone: 972.2.6776599; Fax: 972.2.6437940; E-mail: beng@cc.huji.ac.il.

View this article at: http://www.jci.org/articles/view/60002?key=383987e4717d91eb619d

CARDIOVASCULAR DISEASE: Linking independent risk factors for atherosclerosis

Atherosclerosis is a disease of the major arterial blood vessels that is one of the major causes of heart attack and stroke. High levels of cholesterol in the blood and elevated numbers of immune cells in the blood (a condition known as leukocytosis) are independent risk factors for atherosclerosis. A team of researchers, led by Andrew Murphy, at Columbia University, New York, has now defined in mice a mechanistic link between high levels of cholesterol in the blood, leukocytosis, and the development of atherosclerosis. The authors suggest that targeting the mechanistic link they uncovered could provide a new approach to preventing atherosclerosis. In an accompanying commentary, Christian Weber and Oliver Soehnlein, at Ludwig-Maximilians-University Munich, Germany, discuss in detail the therapeutic implications of the work of Murphy and colleagues.

TITLE: ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

AUTHOR CONTACT:
Andrew J. Murphy
Columbia University, New York, New York, USA.
Phone: 212.305.5789; Fax: 212.305.5052; E-mail: am3440@columbia.edu.

View this article at: http://www.jci.org/articles/view/57559?key=b09574f6c14b84d4fb34

ACCOMPANYING COMMENTARY

TITLE: ApoE controls the interface linking lipids and inflammation in atherosclerosis


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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
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