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JCI online early table of contents: Sept. 19, 2011
Date:9/19/2011

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Peripheral T cell lymphomas are a group of rare and usually aggressive lymphomas (cancers involving cells of the immune system). A team of researchers, led by Charles Roberts, at the Dana-Farber Cancer Institute, Boston, has identified in a mouse model of peripheral T cell lymphoma, the cell from which the lymphoma develops. In this model, the cell of origin a mature CD44hiCD122loCD8+ T cell resembled a subset of immune cells that has capacity for self-renewal and robust expansion, features shared with stem cells. Further analysis determined that signaling to CD44hiCD122loCD8+ T cells via a protein complex on their surface known as the TCR was required for the development of the lymphoma. Roberts and colleagues therefore suggest that targeting signals downstream of the TCR could provide a way to treat peripheral T cell lymphomas, which are usually hard to treat.

TITLE: TCR-dependent transformation of mature memory phenotype T cells in mice

AUTHOR CONTACT:
Charles W.M. Roberts
Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Phone: 617.632.6497; Fax: 617.582.8096; E-mail: charles_roberts@dfci.harvard.edu.

View this article at: http://www.jci.org/articles/view/37210?key=fb9fca9f16ef9d50fe52


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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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