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JCI online early table of contents: Sept. 19, 2011
Date:9/19/2011

ells outFOXed by HIV

In most individuals, infection with HIV-1 leads to severe immune system deficiency. Much research has focused on the loss of immune cells known as CD4+ T cells that occurs, since these cells themselves can be infected with the virus. Much less is known about the profound deregulation of immune cells known as B cells, which are critical for riding the body of invading viruses through their production of molecules known as antibodies. A team of researchers, led by Elias Haddad and Rafick-Pierre Skaly, at the Vaccine and Gene Therapy Institute, Port St. Lucie, has now investigated this issue and identified a molecular mechanism responsible for the progressive depletion of a subset of B cells (specifically peripheral CD27+ memory B cells) in individuals chronically infected with HIV-1. This mechanism provides potential targets for enhancing B cell function, and thereby restoring antibody responses, including toward HIV-1, in individuals infected with HIV-1.

TITLE: Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis

AUTHOR CONTACT:
Elias K. Haddad
Vaccine and Gene Therapy Institute, Port St. Lucie, Florida, USA.
Phone: 772.971.5099; Fax: 772.345.3675; E-mail: ehaddad@vgtifl.org.

Rafick-Pierre Skaly
Vaccine and Gene Therapy Institute, Port St. Lucie, Florida, USA.
Phone: 772.345.4785; Fax: 772.345.3675; E-mail: sekaly@vgtifl.org.

View this article at: http://www.jci.org/articles/view/59211?key=3766c49f51ed0a0ec71c


IMMUNOLOGY: Genetic link to severe bacterial meningitis identifies potential therapeutic strategy

Meningitis is inflammation of the protective membranes covering the brain and spinal cord. When caused by bacteria it is a life-thre
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Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

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