Sherwin and colleagues found that in nonobese individuals with low levels of glucose in their blood, certain regions of the brain were triggered in response to food cues and the individuals had a great desire for high-calorie foods. If these individuals had a normal level of glucose in their blood, different regions of the brain were triggered by the food cures and the individuals were less interested in high-calorie foods. Importantly, this ability of normal levels of glucose in the blood to reduce desire for high-calorie foods was not present in individuals who were obese.
TITLE: Circulating glucose levels modulate neural control of desire for high-calorie foods in humans
Robert S. Sherwin
Yale University School of Medicine, New Haven, Connecticut, USA.
Phone: 203.785.4183; Fax: 203.737.5558; E-mail: firstname.lastname@example.org.
View this article at: http://www.jci.org/articles/view/57873?key=ec18a1879ada48745025
EDITOR'S PICK: Mast cells reduce toxicity of Gila monster and scorpion venom
Gila monsters are large venomous lizards. Although envenomation by the Gila monster is not often fatal to adult humans, it results in intense pain, swelling, weakness, and nausea. A team of researchers, led by Stephen Galli, at Stanford University School of Medicine, Stanford, has now uncovered a natural mechanism by which mice reduce the toxicity, and thereby the morbidity and mortality, of Gila monster venom immune cells known as mast cells release the protein MCPT4, which degrades the Gila monster venom helodermin. This mechanism also acted to reduce the toxicity of venom from 2 species of scorpions. These data provide insight into the benefits of mast cells, which have long been viewed as contributors to disease, in particular anaphylaxis and allergic diseases
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Journal of Clinical Investigation