Navigation Links
JCI online early table of contents: Sept. 19, 2011
Date:9/19/2011

EDITOR'S PICK: Link between ageing and Huntington disease provides candidate therapeutic target

Aging is a major risk factor for the progression of neurodegenerative diseases, including Huntington disease (HD). Morris White and colleagues, at Harvard Medical School, Boston, have now determined that modulating levels of the signaling protein Irs2 changes disease progression in a mouse model of HD. Specifically, increasing Irs2 levels in the brain increased nerve cell damage and reduced lifespan. Conversely, decreasing Irs2 levels reduced nerve cell damage, attenuated symptoms of disease, and increased lifespan. It has been previously shown that reducing Irs2 signaling increases the life span of mice; the data generated by White and colleagues suggests something more specific, that reducing IRS2 signaling could help slow the progression of HD.

TITLE: IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

AUTHOR CONTACT:
Morris F. White
Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.
Phone: 617.919.2846; Fax: 617.730.0244; E-mail: morris.white@childrens.harvard.edu.

View this article at: http://www.jci.org/articles/view/46305?key=ee2dfb41e6329f0f6012


EDITOR'S PICK: High-calorie food 'looks' different to obese individuals

The number of individuals who are obese and suffer with its associated health problems has reached epidemic levels. One factor behind this is that we are constantly surrounded by high-calorie foods and/or images of these foods. Robert Sherwin and colleagues, at Yale University School of Medicine, New Haven, have now visualized differences in the way that the brains of obese and nonobese individuals respond to visual cues of high-calorie foods.


'/>"/>
Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. JCI online early table of contents: Sept. 12, 2011
2. 2011 European Muldisciplinary Cancer Congress abstracts online Sept. 12
3. JCI online early table of contents: Sept. 1, 2011
4. Illegal Online Pharmacies Prey on Consumers
5. Women, Whites Most Likely to Seek Health Info Online: Survey
6. JCI online early table of contents: July 18, 2011
7. JCI online early table of contents: July 11, 2011
8. JCI online early table of contents: July 1, 2011
9. JCI online early table of contents: June 13, 2011
10. NYU Langone rheumatologists share insight with online RA community
11. JCI online early table of contents: June 1, 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... health concerns in the United States, with 32 percent ... 2012. As health problems such as childhood obesity grow, ... the problem. , A new study, led by Jenine ... at Washington University in St. Louis, examined the use ... conversations about the issue of overweight kids. , The ...
(Date:7/10/2014)... and Human Services (HHS) has announced a three-year grant ... Center totaling $4.7 million to support a new national ... cancer. , Titled "Evidence-Conformant Oncology Care," the project ... enhance care for adult cancer patients with late-stage disease, ... utilization. , "We believe that the best ...
(Date:7/10/2014)... to 70% of Parkinson,s disease (PD) patients experience ... life. Some patients have disturbed sleep/wake patterns such ... other patients may be subject to sudden and ... patients may exhibit REM-sleep behavior disorder (RBD), characterized ... before motor symptoms appear. A review in the ...
(Date:7/10/2014)... Huddersfield could help to improve the quality of some ... as butter, mayonnaise, yoghurt and fruit drinks and ... her work. , Katerina gained her MSc degree in ... she has embarked on research for a PhD. ... investigating the potential of carbohydrates extracted from the pods ...
(Date:7/10/2014)... 10, 2014) A research review identifying the clinical ... first step in the process of developing evidence-based guidelines ... new report published by Neurosurgery , ... Surgeons . The journal is published by Lippincott ... Wolters Kluwer Health . , Based on analysis ...
Breaking Medicine News(10 mins):Health News:Study looks at how Twitter can be used to address specific health issues 2Health News:UH Case Medical Center awarded $4.7 million grant from HHS 2Health News:UH Case Medical Center awarded $4.7 million grant from HHS 3Health News:Sleep disturbances, common in Parkinson's disease, can be early indicator of disease onset 2Health News:World interest in research work on the benefits of the Okra plant 2Health News:What's a concussion? Review identifies four evidence-based indicators 2Health News:What's a concussion? Review identifies four evidence-based indicators 3
... study which estimated obesity-related risk factors have indicated that ... prevalence of health risks// like hypertension, diabetes and hypercholesterolemia. ... main role in predisposing women to major health risks ... ,Obesity diagnosis and treatment are typically based on body ...
... Women's Hospital is all set to cancel several hundred ... //of elective surgeries beginning yesterday. ,According to ... 1800 patients would be unable to have a surgery ... Manager of the Central Area Health Service, Terry Mehan, ...
... accused the Government; of trying to "privatise the NHS ... large private// sector companies to apply for the management ... notice on the contract in the Official Journal of ... the implementation of the vision and step change from ...
... health authorities are reconsidering recent changes in visa rules that ... to work in the National Health Service. ,The department ... place a new system by which employers would need to ... a work permit for someone from outside the European Union. ...
... of 87 Hepatitis cases have been detected in Moga out ... health department said today//. ,The infected people ... of 13 doctors, Civil Surgeon Dr H P S Sandhu ... 69 cases from a private doctor and the local clinical ...
... environmental factors such as common infections may be a ... ,The authors of the study, from Leeds and ... out a sophisticated statistical analysis using information from the ... and young adults were diagnosed. ,The study ...
Cached Medicine News:Health News:Obese Women are more likely to suffer from Major Health Risks 2Health News:Obese Women are more likely to suffer from Major Health Risks 3Health News:Surgery cancellations in Queens land Hospital 2Health News:Government Accused Of Yielding NHS To Outside Interests 2Health News:Britain Reconsidering New Visa Rules for Indian Doctors 2Health News:Environmental Factors Trigger Onset of Diabetes 2
(Date:1/14/2014)... 14, 2014  Luminex Corporation (Nasdaq: LMNX ) today ... quarter of 2013 on Monday, February 3, 2014. A press ... close of trading. (Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ) ... the operating highlights and financial results for the fourth quarter ...
(Date:1/14/2014)... The Brandeis Medical Center, led by Dr. Emmanuel Brandeis ... affordable laser tattoo removal experience with the advanced Astanza Duality laser ... high quality cosmetic services with cutting edge medical technology and offering ... California has seen a dramatic increase in the presence ...
(Date:1/14/2014)... -- Acumed,s new SLIC Screw System - a jointed ... place and insert the screw accurately - offers surgeons ... repair or reconstruction as it holds the bones reduced ... http://photos.prnewswire.com/prnh/20140114/MN45636 ) The SLIC Screw is ...
Breaking Medicine Technology:Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3
The Model 5305 is a hand-held, portable, lightweight pulse oximeter designed for spot checking. It has a NiCad rechargeable battery....
The Model 340DT is a new desk top pulse oximeter that was designed for continuous pulse oximetry and has visual and audible alarms to aid with patient monitoring....
The Model 305 is a hand-held, portable, lightweight oximeter designed for spot checking. It has a NiCad rechargeable battery....
... memory capabilities for overnight sleep screening., ,The ... and pulse rate data, and can operate in ... ,1. The Model 130 can retain up ... patient, making the device ideally suited for treadmill ...
Medicine Products: