Navigation Links
JCI online early table of contents: Sept. 13, 2010
Date:9/13/2010

(fH), a negative regulator of the complement pathway. Consistent with this, studies in animal models have linked DDD to activation of complement. In this paper, Santiago Rodriguez de Crdoba and colleagues, at the Centro de Investigaciones Biolgicas, Madrid, identified a familial case of DDD linked to a gain of function mutation in the C3 gene that rendered the protein resistant to cleavage and inactivation by fH. The authors believe that this finding will be important in the treatment of human patients, as it suggests that fH replacement will be ineffective in those patients with DDD that carry C3 mutations. Furthermore, this work reveals the structural properties of C3 that are relevant to its inactivation, and thus may be critical in the development of therapeutics.

TITLE:

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation

AUTHOR CONTACT:
Santiago Rodrguez de Crdoba,
Centro de Investigaciones Biolgicas, Madrid, Spain.
Phone: 34.918373112; Fax: 34.915360432; E-mail: SRdeCordoba@cib.csic.es.

View this article at: http://www.jci.org/articles/view/43343?key=10a2d12b59b663b040c1


CARDIOLOGY Taking fatty acid oxidation to heart

The heart generates most of its energy by burning fats (or lipids) through a process called fatty acid oxidation (FAO). Despite this reliance on fat for energy, increased lipid accumulation in the heart can lead to reduced heart function in patients with obesity and type 2 diabetes. The proteins PPAR-alpha and PPAR-gamma are thought to play a role in promoting lipid accumulation and FAO in fat tissue, and increased expression and activation of PPAR-alpha and -gamma in the heart leads to cardiomyopathy, i.e., weakening of the heart muscle.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... 30, 2014 The Plastic Surgery Group ... Jersey and even in the U.S. to provide clients ... off of patients’ waists with deep-tissue heating. , Unlike ... sections, Vanquish is more inclusive to target large sections ... comfortably under panels about one inch away from their ...
(Date:8/30/2014)... The establishment and creation of ... one of the main strategies of the Church ... impact around the world. , Architecturally stellar buildings ... executives and trainers deliver L. Ron Hubbard's spiritual ... statistics demonstrate that significant reduction in crime, major ...
(Date:8/30/2014)... Seniors Guide, the comprehensive guide to all things senior, ... Disease, Dementia, and Memory Loss . , Country singer Glen ... with the Alzheimer’s, inspired Seniors Guide writers to review the ... movie, out on October 14, 2014, shows a glimpse of ... disease – which inspires a final tour from the musician ...
(Date:8/30/2014)... HealthDay Reporter FRIDAY, Aug. 29, ... on for broken bones or other orthopedic trauma shops around ... Less-educated patients and patients who had used narcotic painkillers ... said study lead author Dr. Brent Morris, a shoulder and ... suggests that doctors aren,t talking to one another about the ...
(Date:8/30/2014)... plant-based medication commonly used to treat gout, before ... reducing potential complications from this type of surgery, ... adverse effects, according to a study published by ... early online to coincide with its presentation at ... complications after cardiac surgery include postpericardiotomy syndrome (the ...
Breaking Medicine News(10 mins):Health News:NJ Top Docs Presents, The Plastic Surgery Group 2Health News:Cradle of Aviation Museum Opens Its Doors to Long Island Scientologists 2Health News:Alzheimer’s Disease and Dementia Focus on Retirement Website SeniorsGuideOnline.com 2Health News:'Doctor-Shopping' for Painkillers Common After Broken-Bone Surgery, Study Finds 2Health News:'Doctor-Shopping' for Painkillers Common After Broken-Bone Surgery, Study Finds 3Health News:Medication shows mixed results in reducing complications from cardiac surgery 2
... get vaccinated against influenza to help protect ... Creek Square during this ... time of year, - Last year, the 2006-2007 influenza season peaked in Austin between late ... January and mid March,- According to ...
... for Women,s Health Research Report and Media Briefing ... WASHINGTON, Nov. 13 Women are more,susceptible ... as pregnancy, postpartum and perimenopause, according to a ... a Washington, D.C.-based,advocacy organization, released at a media ...
... Technology Corp., CALGARY, Nov. 13 /PRNewswire-FirstCall/ - The ... September 30, 2007, it,recorded a net loss of $17.1 ... million. In the same quarter last year, the company ... per share, on revenues of $8.2 million. In ...
... mom calls vaccine ,family priority, this season , , TUESDAY, Nov. ... (for Alias ) and the heart of husband Ben ... is to protect the health of the couple,s 2-year-old daughter, ... than 100 children die every year from this disease -- ...
... formation is an important feature of chronic pancreatitis, especially ... in size, highly irregular in shape and cause enormous ... not well-understood. It is very important to understand the ... before it causes obstruction and damage to the pancreatic ...
... Enables Insurers, Employers, and Government Agencies to Evaluate ... Quality and Cost of Medical Care, ... ; TSX: TOC) has introduced Physician Performance Assessment, an,application that health ... and cost of medical care. The Physician Performance Assessment application ...
Cached Medicine News:Health News:Novartis Vaccines Partners With RediClinic for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 2Health News:Novartis Vaccines Partners With RediClinic for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 3Health News:Novartis Vaccines Partners With RediClinic for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 4Health News:Novartis Vaccines Partners With RediClinic for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 5Health News:Novartis Vaccines Partners With RediClinic for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers 6Health News:Hormonal Changes and Depression: What is the Connection? 2Health News:Hormonal Changes and Depression: What is the Connection? 3Health News:Hormonal Changes and Depression: What is the Connection? 4Health News:Westaim announces 2007 third quarter results 2Health News:Westaim announces 2007 third quarter results 3Health News:Westaim announces 2007 third quarter results 4Health News:Jennifer Garner Puts Flu Shot in the Spotlight 2Health News:Jennifer Garner Puts Flu Shot in the Spotlight 3Health News:Jennifer Garner Puts Flu Shot in the Spotlight 4Health News:The most important candidate genes for pancreatic stone formation 2Health News:Thomson Healthcare Launches Application That Assesses Physician Performance 2Health News:Thomson Healthcare Launches Application That Assesses Physician Performance 3
(Date:8/29/2014)... -- ChemImage will present a workshop focused on hyperspectral ... Science Society,s 22 nd International Symposium on ... .  Forensic Scientists will be in attendance ... can bring to examination procedures. ... Development at ChemImage, will host a workshop during ...
(Date:8/29/2014)... -- In part four of a blog series ... a strategic asset, Mary Baxter, MBA, RPh ., ... Innovation Delivery Solutions business, discusses how expanding patient access ... patients. "Every hospital pharmacist knows that filling ... in a value-based healthcare world," Baxter says. "For the ...
(Date:8/29/2014)... Calif. , Aug. 29, 2014  Pacific Medical ... its new website design . The main website, ... that showcases the company,s new services and content relevant ... implementing a new streamlined design, viewers can now better ... for health care practices and create a more visible ...
Breaking Medicine Technology:ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 2Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 3Five Ways Hospital Pharmacies Can Fulfill Their Quality Care Mission 4PMDS Announces New Website 2
... Implementation of electronic medical records (EMR) by healthcare providers ... so many reports, the determining factor responsible for this ... reported by USA Today, upfront costs (which include purchasing ... $36,000 per physician. In addition, the learning curve for ...
... N.J., Oct. 30 Novo Nordisk Inc. announced the ... hemophilia(TM) campaign through a rebranded Web site and ... face many daily challenges, and Novo Nordisk is committed ... a lifetime of possibilities. , These new online resources ...
Cached Medicine Technology:Electronic Medical Record System and More 2Electronic Medical Record System and More 3Novo Nordisk is Changing Possibilities in Hemophilia 2Novo Nordisk is Changing Possibilities in Hemophilia 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: