Navigation Links
JCI online early table of contents: Sept. 13, 2010
Date:9/13/2010

w York, New York.
Phone: 212.639.3573; E-mail: harrisok@mskcc.org.

View this article at: http://www.jci.org/articles/view/42442?key=7ef55d4a4ce9ffed3af0


EDITOR'S PICK Signaling hope for Polycystic Kidney Disease

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disease that results in chronic kidney failure. Although the genes responsible for ADPKD have been identified (PKD1, PKD2), relatively little is known about how mutations in these genes promote cyst growth molecularly. In this paper, scientists at Children's Hospital in Boston, lead by Jordon Kreidberg, investigated the signaling pathways that go awry in the disease using mouse kidney epithelial cells in which Pkd1 was genetically deleted. They found that the protein c-Met was hyperactive in Pkd1-deficient cells, resulting in increased mTOR signaling, a pathway that had previously been linked to cyst formation. The increase in c-Met activity was related to sequestration of the protein c-Cbl in a cellular compartment known as the golgi, which increased c-Met protein stability. In support of a critical role for c-Met activity in disease progression, pharmacological inhibition of c-Met decreased mTOR activity and blocked cyst formation in a mouse model of ADPKD, leading the authors to suggest that c-Met is a potential therapeutic target in patients with ADPKD.

TITLE:

Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease

AUTHOR CONTACT:

Jordan Kreidberg,
Children's Hospital, Boston, Massachusetts, USA.
Phone: 617.919.2959; Fax: 617.730.0129;
E-mail: Jordan.Kreidberg@childrens.harvard.edu.

View this article at:

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... Ericdress.com today announced a site-wide ... to 85% off, on all its clothing, shoes and other ... 1 – 7, 2014 only. , At the special offer, ... above $109 can enjoy an extra $10 discount. Moreover, orders ... business specially recommended its new collection of 2015 evening dresses ...
(Date:11/27/2014)... As everyone knows, Cyber Monday is a crazy shopping ... Tidebuy is now providing many big promotions on its ... 15% of the current prices. The discount are up to ... free shipping (for orders above $88) from Dec. 1 – ... and more people are willing to shop on the internet. ...
(Date:11/27/2014)... 28, 2014 Recently, DressVe , the ... Cyber Monday Sales, which are valid during Nov. 29 – ... available on these new dresses, up to 90% off. In ... Click to view more at http://www.dressve.com/ , Dresses ... a great way to showcase somebody’s personality and figure. The ...
(Date:11/27/2014)... 2014 The report “Blepharitis – ... the therapeutic development for Blepharitis, complete with comparative ... target, mechanism of action (MoA), route of administration ... and featured news and press releases. It also ... for Blepharitis and special features on late-stage and ...
(Date:11/27/2014)... (PRWEB) November 27, 2014 TORQ Cycle is ... professional instructors who go out of the way to help ... people to get fit and do their workouts sincerely using ... they understand the fact that it is important for people ... past year, they have made sure that people take to ...
Breaking Medicine News(10 mins):Health News:Ericdress.com Special Monday Sales Are Ready For Everyone 2Health News:Tidebuy.com Launching Overcoats Sales for the Special Monday in 2014 2Health News:DressVe.com Introduces Its 2014 Special Monday Sales To The Global Customers 2Health News:Blepharitis Pipeline Market Review on Drugs and Companies H2 2014 2Health News:Blepharitis Pipeline Market Review on Drugs and Companies H2 2014 3Health News:Blepharitis Pipeline Market Review on Drugs and Companies H2 2014 4Health News:The new wave in Fitness : Stay Active with Innovative Indoor Cycling Programs 2
... technology reduces radiation exposure, eliminates workflow complexity, and ... MEDRAD,s Intego(TM) PET Infusion System has been named ... innovative products of the year. The magazine ... readership considers to be the most far-reaching, game ...
... Members Say Patient Care at Risk With Threats ... from three major unions representing more than 3,000 ... Care (ARH) facilities in eastern Kentucky and southern ... of directors to meet with them to discuss ...
... Foundation Health Plan,Inc., Kaiser Foundation Hospitals and their subsidiaries ... quarter ended December 31,2008, compared to $9.6 billion in ... million in the fourth quarter of 2008, compared to ... year. The difference between the two,quarters was primarily ...
... general health, functioning improve , , FRIDAY, Feb. 13 ... lose weight, exercise can improve postmenopausal women,s quality of ... sedentary postmenopausal women (average age 57.4) randomly assigned to ... groups: an exercise expenditure of 4 kilocalories per kilogram ...
... As the FDA and pharmaceutical manufacturers contemplate ... plans for extended release opioids, thousands of clinicians ... discovered a resource that supports the safe and ... in Pain ( www.emergingsolutionsinpain.com ) is a ...
... more to promote awareness, study says , , FRIDAY, Feb. 13 ... name or role -- the doctors assigned to their care, ... "The majority of hospitalized patients we looked at were not ... study author Dr. Vineet Arora, associate program director at the ...
Cached Medicine News:Health News:MEDRAD Molecular Imaging Earns Top Rank in Innovation 2Health News:MEDRAD Molecular Imaging Earns Top Rank in Innovation 3Health News:Health Care Workers Call on ARH Board Members to Meet, Develop Real Strategy to Deal With Hospitals' Bottom Line 2Health News:Health Care Workers Call on ARH Board Members to Meet, Develop Real Strategy to Deal With Hospitals' Bottom Line 3Health News:Kaiser Foundation Health Plan, Inc. and Kaiser Foundation Hospitals Report Fourth Quarter and Fiscal-Year 2008 Results 2Health News:Kaiser Foundation Health Plan, Inc. and Kaiser Foundation Hospitals Report Fourth Quarter and Fiscal-Year 2008 Results 3Health News:Kaiser Foundation Health Plan, Inc. and Kaiser Foundation Hospitals Report Fourth Quarter and Fiscal-Year 2008 Results 4Health News:Kaiser Foundation Health Plan, Inc. and Kaiser Foundation Hospitals Report Fourth Quarter and Fiscal-Year 2008 Results 5Health News:Exercise Boosts Quality of Life in Postmenopausal Women 2Health News:Opioid Safety and Efficacy Web Resource for Clinicians Supports Education and Practice Needs 2Health News:Opioid Safety and Efficacy Web Resource for Clinicians Supports Education and Practice Needs 3Health News:Many Hospital Patients Can't ID Their Doctors 2Health News:Many Hospital Patients Can't ID Their Doctors 3
(Date:11/26/2014)... Nov. 26, 2014  Aethlon Medical, Inc. (OTCQB:AEMD), announced ... to raise approximately $3.3 million at a price of ... one institutional healthcare focused investor. Each unit consists of one ... share purchase warrant. Each whole warrant entitles the holder ... $0.30 for a period of five years from closing.  ...
(Date:11/26/2014)... , Nov. 26, 2014 Lexicon ... announced the completion of previously announced concurrent financing ... After fees and estimated offering expenses, Lexicon anticipates ... transactions.  The transactions consisted of: , ... stock, pursuant to a registration statement that has ...
(Date:11/26/2014)... Investor-Edge has initiated coverage on the following equities: ... (NASDAQ: HZNP ), Endocyte Inc. (NASDAQ: ... and Theravance Inc. (NASDAQ: THRX ). Free research ... . On Tuesday, November 25, 2014, the NASDAQ ... Average edged 0.02% lower, to finish the day at 17,814.94, ...
Breaking Medicine Technology:Aethlon Medical Announces $3.3 Million Equity Investment 2Aethlon Medical Announces $3.3 Million Equity Investment 3Lexicon Announces Completion Of $280 Million In Financing Transactions 2Lexicon Announces Completion Of $280 Million In Financing Transactions 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5
... Amex: NBS ), an international biopharmaceutical company with ... the 2011 BIO CEO & Investor Conference. Hosted by the ... Conference will take place February 14-15 at the Waldorf-Astoria in ... will present in the Duke of Windsor Room at 8 ...
... LIONVILLE, Pa., Feb. 10, 2011 West Pharmaceutical Services, Inc. ... release 2010 fourth quarter financial results before the market opens ... conference call to discuss the results and business expectations at ... dial 866-831-6267 (U.S.) or 617-213-8857 (International). The passcode is 14994078. ...
Cached Medicine Technology:NeoStem to Present at 13th Annual BIO CEO & Investor Conference 2NeoStem to Present at 13th Annual BIO CEO & Investor Conference 3NeoStem to Present at 13th Annual BIO CEO & Investor Conference 4West to Host 2010 Fourth Quarter Conference Call 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: