Navigation Links
JCI online early table of contents: Sept. 13, 2010
Date:9/13/2010

EDITOR'S PICK Hi-JAK-ing Cancer by Inhibiting Jak2

Myeloproliferative neoplasms (MPN) comprise a family of blood cancers characterized by clonal expansion of a single blood cell type. Untreated, these cancers can progress to bone marrow failure and acute myeloid leukemia. Several groups have identified activating mutations in the JAK2 gene as associated with MPN; JAK2 inhibition has therefore emerged as approach to MPN therapy. Thus far, however, JAK2 inhibition strategies have had limited efficacy and have been accompanied by significant toxicity. In this paper, Ross Levine and his group at the Memorial Sloane Kettering Cancer Center, New York, describe an indirect approach to reducing JAK2 activity by pharmacologically targeting HSP90, a protein that stabilizes JAK2. Inhibiting HSP90 normalized blood counts and improved survival in two mouse models of MPN, and the treatment promoted JAK2 degradation in samples from MPN patients. The authors believe that targeting HSP90, perhaps in combination with JAK2 inhibition, may be the way forward in the treatment of patients with MPN.

TITLE:

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans

AUTHOR CONTACT:

Ross L. Levine,
Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Phone: 646.888.2796; Fax: 646.422.0890; E-mail: leviner@mskcc.org.

Gabriela Chiosis,
Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Phone: 646.888.2238; Fax: 646.422.0416; E-mail: chiosisg@mskcc.org.

James E. Bradner,
Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Phone: 617.632.6629; Fax: 617.582.7370; E-mail: james_Bradner@dfci.harvard.edu.

Media contact
Kathleen Harrison
Memorial Sloane Kettering Cancer Center, Ne
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... August 31, 2015 , ... NSF International, ... the water, food, health sciences and consumer goods industries, has recognized Clean Water ... iron filtration media, Pro-OX Manganese Dioxide. , Developed by a team of scientists ...
(Date:8/31/2015)... ... August 31, 2015 , ... GenHart Software, LLC, a rising ... to help small businesses operate as efficiently and cost effectively as possible, with a ... impact in their first year of operation – and the Charleston business community is ...
(Date:8/30/2015)... ... August 31, 2015 , ... The acknowledgement from Caribbean ... by TripAdvisor earlier in 2015. The island of Providenciales itself received a TripAdvisor ... The Venetian on Grace Bay is offering a special promotion for newlyweds and honeymooners ...
(Date:8/30/2015)... ... 31, 2015 , ... This month, top rated New York ... living facilities and nursing homes protect their residents from neglect and improper care ... at the company, security systems don’t just protect; they also help monitor patients ...
(Date:8/30/2015)... ... 30, 2015 , ... InHealth Media ( http://www.inhealthmedia.com ) announced ... Director for InHealth Media. Mr. Spector comes with a wide array of ... on-air television, producing shows, on air-radio and media relations. , Brian joins ...
Breaking Medicine News(10 mins):Health News:NSF International Has Recognized Clean Water Systems & Stores Inc Facility 2Health News:NSF International Has Recognized Clean Water Systems & Stores Inc Facility 3Health News:GenHart Software, LCC Launches Scheduling, Appointment Reminder, Text Marketing Software Designed to Help Businesses Increase Revenue While Decreasing Client Attrition 2Health News:GenHart Software, LCC Launches Scheduling, Appointment Reminder, Text Marketing Software Designed to Help Businesses Increase Revenue While Decreasing Client Attrition 3Health News:Grace Bay Beach Named a Top Beach Destination for Weddings 2Health News:Total Security Announces Security Systems Tips for New York Assisted Living Facilities and Nursing Homes 2Health News:Total Security Announces Security Systems Tips for New York Assisted Living Facilities and Nursing Homes 3Health News:InHealth Media Appoints New Global Communications Director 2
... DENVER, Dec. 11 Birner Dental Management,Services, Inc. (Nasdaq: ... practices,announced its regular quarterly dividend. The Company,s board ... cents per share of common stock.,The dividend is payable ... , Birner Dental ...
... Northwestern University biomedical engineer has developed a new optical ... for the early diagnosis of cancer. , The researchers ... are present in cells extremely early on in carcinogenesis. ... changes in human colon cancer cells even when those ...
... health insurer in Pennsylvania to open store in Pittsburgh,s ... PITTSBURGH, Dec. 11 As individuals and seniors ... and small business owners look for health plan options, Highmark ... the first health insurer in the state to open a ...
... men between the ages of 20,and 50 are two ... dysfunction,(ED) as men of other races and ethnicities, according ... American Medical Association,s "Archives of Internal,Medicine".(1) Put another way, ... range are afflicted with this condition, and when the ...
... comes to health insurance quotes , there are no easy ... the military, but that doesn,t mean saving money is totally out ... to maximize your health insurance dollar: -  Do the Math: ... to you, be aware that lower premiums generally come with either ...
... Criteria in Four Major Procedures , , ... identified the nation,s Highest Value Hospitals based on a review ... Survey. The Leapfrog Group is the first national quality ... at the same time demonstrating an appropriate use of resources ...
Cached Medicine News:Health News:Light shines for potential early cancer diagnosis technique 2Health News:Highmark Blue Cross Blue Shield to Open 'Highmark Direct,' a Health Insurance Retail Store 2Health News:Highmark Blue Cross Blue Shield to Open 'Highmark Direct,' a Health Insurance Retail Store 3Health News:Hispanic Men Face Elevated Risk of Erectile Dysfunction 2Health News:How to Save Money on Health Insurance 2Health News:The Leapfrog Group Identifies Nation's 'Highest Value' Hospitals 2Health News:The Leapfrog Group Identifies Nation's 'Highest Value' Hospitals 3
(Date:8/28/2015)... N.C. , Aug. 28, 2015  Delays ... research projects can slow down the decision-making process, ... is, therefore, absolutely critical for biopharmaceutical companies to ... research approval process for quicker and more meaningful ... by Best Practices, LLC, nearly three-quarters of benchmarked ...
(Date:8/28/2015)... Research and Markets ( http://www.researchandmarkets.com/research/686gwf/investigation ) ... on China,s Bevacizumab Market ,2010-2019" report to their ... name of Avastin, bevacizumab injection is the first angiogenesis ... approved by CFDA to treat metastatic colorectal cancer. Currently, ... all come from Roche and its subsidiary Genectech. In ...
(Date:8/28/2015)... , Aug. 28, 2015 Patterson ... Inc. (Nasdaq: PDCO ), is now an ... announced acquisition of Patterson Medical by Madison Dearborn ... retain its name for a transition period before ... rehabilitation and sports medicine products.  With the focused ...
Breaking Medicine Technology:Expediting the Pharmaceutical Market Research Process for Faster Insights 2Investigation Report on China's Bevacizumab Market 2015-2019 2Patterson Medical Positioned for Continued Growth as a Newly Independent Company 2Patterson Medical Positioned for Continued Growth as a Newly Independent Company 3
... March 24, 2011 Reportlinker.com announces that a ... catalogue: Triple Analysis: Colorectal Cancer, ... http://www.reportlinker.com/p0284811/Triple-Analysis-Colorectal-Cancer-Leukemia-and-Pancreatic-Cancer.html This triple analysis focuses ... Leukemia and Pancreatic Cancer. Each of these three ...
... 24, 2011 Reportlinker.com announces that a new ... Process Analytical Technologies for Pharmaceuticals: ... The global market for process analytical ... million in 2010. This market is expected to ...
Cached Medicine Technology:Reportlinker Adds Triple Analysis: Colorectal Cancer, Leukemia and Pancreatic Cancer 2Reportlinker Adds Triple Analysis: Colorectal Cancer, Leukemia and Pancreatic Cancer 3Reportlinker Adds Triple Analysis: Colorectal Cancer, Leukemia and Pancreatic Cancer 4Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 2Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 3Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 4Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 5Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 6Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 7Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 8Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 9Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 10Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 11Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 12Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 13Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 14Reportlinker Adds Process Analytical Technologies for Pharmaceuticals: Global Markets 15
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: