Navigation Links
JCI online early table of contents: Sept. 12, 2011
Date:9/12/2011

on, Massachusetts, USA.
Phone: 617.724.8922; Fax: 617.726.5669; E-mail: ssever@partners.org.

Jochen Reiser
University of Miami, Miami, Florida, USA.
Phone: 305.243.2349; Fax: 305.243.2309; E-mail: jreiser@med.miami.edu.

View this article at: http://www.jci.org/articles/view/58552?key=b618f54191c2ab2d5ed1


NEPHROLOGY: Cells from outside the kidney link two features of chronic kidney disease

Individuals with chronic kidney disease often suffer from anemia. This is because the cells in the kidney that produce erythropoietin, the hormone that stimulates the production of new red blood cells in the bone marrow, are dysfunctional in these individuals. Dysfunction of these cells (fibroblasts) also causes scarring of the kidney, a condition known as renal fibrosis, which is a central feature of chronic kidney disease. Despite the importance of fibroblasts in chronic kidney disease, little is known about their origin and how they are regulated. Now, a team of researchers, led by Motoko Yanagita, at Kyoto University, Japan, has determined that the majority of erythropoietin-producing fibroblasts in the healthy mouse kidney are derived from cells that originally came from outside the kidney. Importantly, in the diseased kidney, these particular fibroblasts became dysfunctional, decreasing production of erythropoietin and contributing to fibrosis. Further, in a mouse model of renal fibrosis, treatment with tamoxifen (a drug FDA approved to treat breast cancer) increased erythropoietin production and decreased fibrosis. The authors therefore suggest that tamoxifen and related drugs could provide benefit to individuals with chronic kidney disease.

TITLE: Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... WA (PRWEB) September 18, 2014 Kent, ... Lake Meridian Chiropractic are pleased to announce that Dawn Kelly ... 24-year-old clinic. Dr. Saggau looks forward to Ms. Kelly ... and administrative talents will make her a key contributor. ... combination of educational, professional, and personal experiences that will ...
(Date:9/18/2014)... Dr. David A. F. Ellis is a Board ... Facial Plastic and Reconstructive Surgery and a Professor at ... Plastic Surgery. He is recognized around the world ... Dr. Ellis will be presenting on numerous injectable topics. ... techniques and various treatments for complications associated with injectable ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Alexandria, VA ... announced today that 10 more communities have joined the ... public health department accreditation. The decisions bring the number ... to 54. PHAB is the non-profit organization that administers ... improve and protect the health of the public by ...
(Date:9/18/2014)... -- Exposure to diverse communities may boost infants, social ... different languages in the park or supermarket could help ... who are different from them, researchers found. ... biased against interacting with and learning from people who ... of Chicago psychology professor, said in a university news ...
(Date:9/18/2014)... Sept. 18, 2014 (HealthDay News) -- Older people become ... That,s because the balance of stress hormones during bereavement ... older people who are grieving are more likely to ... found. "During the difficult weeks and months after ... are the most abundant type of white blood cell ...
Breaking Medicine News(10 mins):Health News:Lake Meridian Chiropractic of Kent, WA Announces that Dawn Kelly Has Been Promoted to the Position of Office Manager 2Health News:Dr. David A. F. Ellis Has Been Invited to Speak at a Conference of the American Academy of Facial Plastic and Reconstructive Surgery in Orlando, Florida 2Health News:Ten More Communities Reaping Benefits of National Accreditation 2Health News:Ten More Communities Reaping Benefits of National Accreditation 3Health News:Ten More Communities Reaping Benefits of National Accreditation 4Health News:Study: Exposure to Diversity Might Boost Baby's Social Skills 2Health News:Grief Can Weigh on Immune System in Older Folks, Study Says 2
... identified a particular combination of health problems that can ... three-fold increase in the risk of mortality. , The ... at Warwick Medical School Dr Oscar Franco, has discovered ... blood sugar are the most dangerous combination of health ...
... ... hospice care to families throughout the San Francisco Bay Area. , ... Walnut Creek, CA (PRWEB) November 2, ... and personal caregiver services in Northern California, has announced the expansion of its services ...
... Video, "Waitin, Room Service" , WASHINGTON, Nov. 2 Lung ... will launch a new public service campaign aimed at creating ... http://www.newscom.com/cgi-bin/prnh/20081016/LCALOGO ) , Dr. Lung Love, a versatile, multi-genre ... Room Service" which is being launched today. , ...
... KENILWORTH, N.J., Nov. 2 Schering-Plough Corporation (NYSE: ... two projects in India to reduce the incidence of ... mass vaccination of dogs. The company will donate $200,000 ... expertise with partners to support successful implementation of the ...
... ... "Leadership in Innovation" Award Winner Patrick Soon-Shiong, MD, Chairman and CEO of Abraxis Health, ... in HealthcareSM Awards Event this week. They were: Dakim, Inc.; Epocrates, Inc.; and Osmetech ... ...
... ... the release of the Office of the National Coordinator for Health Information Technology (ONC) requirements ... by numerous EHR software and services companies that need to be certified. , ... Fort Worth, TX (PRWEB) November 2, 2009 ...
Cached Medicine News:Health News:Researchers identify the 3 killer indicators that are even worse than high cholesterol 2Health News:Professional HealthCare at Home Expands Services to Provide Licensed Hospice Care in Northern California 2Health News:Lung Cancer Alliance Announces New National Campaign Starring Dr. Armando Lung Love 2Health News:Schering-Plough Announces Sponsorship of Rabies-Control Projects in India 2Health News:Schering-Plough Announces Sponsorship of Rabies-Control Projects in India 3Health News:Schering-Plough Announces Sponsorship of Rabies-Control Projects in India 4Health News:Schering-Plough Announces Sponsorship of Rabies-Control Projects in India 5Health News:Patrick Soon-Shiong, MD, and Three Healthcare Companies Win 2009 Innovations in Healthcare Awards 2Health News:Patrick Soon-Shiong, MD, and Three Healthcare Companies Win 2009 Innovations in Healthcare Awards 3Health News:Patrick Soon-Shiong, MD, and Three Healthcare Companies Win 2009 Innovations in Healthcare Awards 4Health News:Drummond Group Plans to Certify Electronic Health Records 2Health News:Drummond Group Plans to Certify Electronic Health Records 3
(Date:9/18/2014)... LA JOLLA, Calif. , Sept. 18, 2014 ... RGLS ), a biopharmaceutical company leading the ... announced today it has initiated its ATHENA natural ... syndrome, a life-threatening genetic kidney disease with no ... characterize the natural decline of renal function markers ...
(Date:9/18/2014)... and ROCKVILLE, Md. , ... SPPI ), a biotechnology company with fully integrated ... in hematology and oncology, and CASI Pharmaceuticals, Inc. (Nasdaq: ... the acquisition, development and commercialization of innovative therapeutics addressing ... market with a primary focus on China ...
(Date:9/18/2014)... 2014  RXi Pharmaceuticals Corporation (NASDAQ: ... on discovering, developing and commercializing innovative therapies ... technologies, today announced that the Company,s President and ... , will present at the 7 th ... September 24, 2014 at 11:20 a.m. EDT.  ...
Breaking Medicine Technology:Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 2Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 3Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 4Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 5Regulus Initiates ATHENA Natural History of Disease Study in Alport Syndrome Patients 6Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 2Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 3Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 4Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 5Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 6Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 7Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 8Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 9Spectrum Pharmaceuticals Out-Licenses Rights for Greater China to CASI Pharmaceuticals for Three of Its Drugs 10RXi Pharmaceuticals to Present at the 7th Annual BioPharm America Conference 2RXi Pharmaceuticals to Present at the 7th Annual BioPharm America Conference 3
Enzyme Immunoassay of -Thromboglobulin Antigen by ELISA Method, 96 tests....
Calibration plasmas for Assays of Low Molecular Weight Heparins (LMWH)using the Anti-Xa method on STA© Analyzers....
Multi-constituent Calibration Plasma for Functional Assays of Coagulation Parameters on STA© Analyzers....
Multi-constituent normal and abnormal plasma controls for routine and specialty assays performed on the STA© family of hemostasis analyzers....
Medicine Products: