Navigation Links
JCI online early table of contents: Sept. 12, 2011
Date:9/12/2011

on, Massachusetts, USA.
Phone: 617.724.8922; Fax: 617.726.5669; E-mail: ssever@partners.org.

Jochen Reiser
University of Miami, Miami, Florida, USA.
Phone: 305.243.2349; Fax: 305.243.2309; E-mail: jreiser@med.miami.edu.

View this article at: http://www.jci.org/articles/view/58552?key=b618f54191c2ab2d5ed1


NEPHROLOGY: Cells from outside the kidney link two features of chronic kidney disease

Individuals with chronic kidney disease often suffer from anemia. This is because the cells in the kidney that produce erythropoietin, the hormone that stimulates the production of new red blood cells in the bone marrow, are dysfunctional in these individuals. Dysfunction of these cells (fibroblasts) also causes scarring of the kidney, a condition known as renal fibrosis, which is a central feature of chronic kidney disease. Despite the importance of fibroblasts in chronic kidney disease, little is known about their origin and how they are regulated. Now, a team of researchers, led by Motoko Yanagita, at Kyoto University, Japan, has determined that the majority of erythropoietin-producing fibroblasts in the healthy mouse kidney are derived from cells that originally came from outside the kidney. Importantly, in the diseased kidney, these particular fibroblasts became dysfunctional, decreasing production of erythropoietin and contributing to fibrosis. Further, in a mouse model of renal fibrosis, treatment with tamoxifen (a drug FDA approved to treat breast cancer) increased erythropoietin production and decreased fibrosis. The authors therefore suggest that tamoxifen and related drugs could provide benefit to individuals with chronic kidney disease.

TITLE: Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... TX (PRWEB) , ... July 03, 2015 , ... ... the United States, named Mariah N. Manzanares, MD as the new Medical Director of ... new facility medical director of our Frisco facility,” said Dr. James M. Muzzarelli, Executive ...
(Date:7/2/2015)... VA (PRWEB) , ... July 02, 2015 , ... sweetFrog ... Albany, Mississippi. The opening is the first sweetFrog store located in Mississippi. The premium ... growing companies in 2014. , The store, located at 104 Railroad Avenue, New Albany, ...
(Date:7/2/2015)... ... July 02, 2015 , ... When Walker Parking Consultants specified ... of Minnesota, they knew it would save the university energy and maintenance costs. ... the total energy savings after installation was an impressive 89 percent, which resulted ...
(Date:7/2/2015)... ... ... As Americans celebrate the Fourth of July outdoors this weekend, local physicians ... July is UV Safety Month, and physicians at American Family Care and AFC Doctors ... Experts say most skin cancers can be found early with regular skin exams. Physicians ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... ActiveBunch.com recently ... passion for social fitness. Built to function as a lifestyle community, Active Bunch allows ... the opportunity to network, meet, and participate in discussions or group events. , ...
Breaking Medicine News(10 mins):Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 2Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 3Health News:sweetfrog Opens First Location in Mississippi 2Health News:Kenall’s TekDek™ Helps University Achieve Award-Winning Energy Savings in Parking Structure Lighting Retrofit 2Health News:Local Physicians Warn of Holiday Health Hazards 2Health News:Local Physicians Warn of Holiday Health Hazards 3Health News:Local Physicians Warn of Holiday Health Hazards 4Health News:ActiveBunch.com Launches as a Social Community for People with Active Lifestyles 2
... to Create a Sustainable Model for ... ... ZMH ; SWX: ZMH) today announced comprehensive changes in its,corporate compliance ... support the development and marketing,of products and services that address unmet clinical ...
... 17 Family Research Council,Action applauds GOP Presidential ... from Villanova University supporting the pro-life,platform of the ... record of possible running mates., FRC Action,s ... to hear Senator McCain depict his support for ...
... The U.S. Agency for,International Development and Iraq,s ... Understanding (MOU) outlining a shared vision and,collaborative effort ... to,deliver health services to Iraqi citizens, and contribute ... MOU strengthens the strategic cooperation between the MoH ...
... Medical,Innovations, Inc. (Amex: IMA ), a global ... it will release its first quarter,2008 earnings on ... host a,conference call beginning at 10:00 a.m. (Eastern ... other corporate matters. During the conference,call the Company ...
... 17 LabX.com, the first,business-to-business internet auction ... it has acquired the print and digital,publication ... Amherst ,NH . Vicon Publishing will continue ... Magazine, Controlled Environments Magazine(R), and,Forensic Magazine(R). Lab ...
... HVAC company provides tips for improving indoor air quality, ... National,Indoor Comfort Week, Atlas Butler Heating and Cooling is ... in their homes and offices,is free of harmful pollutants., ... indoor,environmental systems on which everyone relies, and honors the ...
Cached Medicine News:Health News:Zimmer Announces New Compliance Model 2Health News:Zimmer Announces New Compliance Model 3Health News:Zimmer Announces New Compliance Model 4Health News:Zimmer Announces New Compliance Model 5Health News:Zimmer Announces New Compliance Model 6Health News:Zimmer Announces New Compliance Model 7Health News:FRC Action Praises John McCain's Pro-Life Comments 2Health News:Iraq's Ministry of Health and USAID Sign Memorandum of Understanding to Increase Cooperation in Public Management 2Health News:Inverness Medical Innovations Schedules Conference Call for 10:00 a.m. ET April 24, 2008 to Discuss First Quarter 2008 Results 2Health News:Internet Auction Site LabX Acquires Lab Manager Magazine(R) Print and Digital Publications, E-Newsletters, Website and Conference 2Health News:National Indoor Comfort Week - A Breath of Fresh Air for Allergy Sufferers 2
(Date:7/2/2015)... According to a new market research ... Spinal Cord Stimulation, Transcranial Magnetic Stimulation), Application (Depression, Parkinson,s, Tinnitus, ... published by MarketsandMarkets, the global Neuromodulation Market is estimated at ... Billion by 2020, at a CAGR of 11.2% during the ... 4 market data T ables and ...
(Date:7/2/2015)... Conn. , July 2, 2015 Numotion,s ... Executive Officer announced that Tamas Feitel has ... Feitel joins Numotion after a highly successful 18 year ... leadership roles driving strategy, profitability, and productivity to result ... most recent position was Chief Financial Officer for GE ...
(Date:7/2/2015)... DUBLIN , June 25, 2015 /PRNewswire/ ... http://www.researchandmarkets.com/research/8mfjxh/2015_new ) has announced the addition of ... Chemistry and Immunodiagnostics: Global Challenges, Emerging Technologies, ... 2015 New Frontiers in Clinical ... Competitive Landscape is a new seven-country strategic ...
Breaking Medicine Technology:Neuromodulation Market Worth $6.20 Billion by 2020 2Neuromodulation Market Worth $6.20 Billion by 2020 3Neuromodulation Market Worth $6.20 Billion by 2020 4Numotion Names Tamas Feitel Chief Financial Officer 2New Frontiers in 2015 Global Clinical Chemistry and Immunodiagnostics Market: Challenges, Emerging Technologies, Competitive Landscape 2
... Sept. 18 Worldwide markets of,approved EGFr/HEr2 inhibitors grew ... to more than $3.2 billion, exceeding total sales reported ... expanding,indications for these drugs and fueling continued rapid market ... than 50 novel,agents targeting this pathway are in development. ...
... FOLD ) today announced that it plans to ... HCl) for Pompe Disease at the,American Society of Human ... CA. This plan was announced by John Crowley, President ... & Medtech 2007 Conference in London, United Kingdom. ...
Cached Medicine Technology:Amicus Therapeutics Announces Plans to Present Phase 1 Data for AT2220 for Pompe Disease 2
Available in 10 beautiful opaque colors....
A new generation of enhancing color contact lens designed specifically for light eyes....
Expressions Accents contact lenses let you enhance your eyes natural color while enjoying incredible comfort and outstanding vision quality....
... the appearance of photo-aged skin, removes age ... telangiectasias, and broken capillaries. This innovative new ... pigmentary sun damage through a process called ... and the Nd:YAG Laser is optimized for ...
Medicine Products: