Navigation Links
JCI online early table of contents: Sept. 12, 2011
Date:9/12/2011

on, Massachusetts, USA.
Phone: 617.724.8922; Fax: 617.726.5669; E-mail: ssever@partners.org.

Jochen Reiser
University of Miami, Miami, Florida, USA.
Phone: 305.243.2349; Fax: 305.243.2309; E-mail: jreiser@med.miami.edu.

View this article at: http://www.jci.org/articles/view/58552?key=b618f54191c2ab2d5ed1


NEPHROLOGY: Cells from outside the kidney link two features of chronic kidney disease

Individuals with chronic kidney disease often suffer from anemia. This is because the cells in the kidney that produce erythropoietin, the hormone that stimulates the production of new red blood cells in the bone marrow, are dysfunctional in these individuals. Dysfunction of these cells (fibroblasts) also causes scarring of the kidney, a condition known as renal fibrosis, which is a central feature of chronic kidney disease. Despite the importance of fibroblasts in chronic kidney disease, little is known about their origin and how they are regulated. Now, a team of researchers, led by Motoko Yanagita, at Kyoto University, Japan, has determined that the majority of erythropoietin-producing fibroblasts in the healthy mouse kidney are derived from cells that originally came from outside the kidney. Importantly, in the diseased kidney, these particular fibroblasts became dysfunctional, decreasing production of erythropoietin and contributing to fibrosis. Further, in a mouse model of renal fibrosis, treatment with tamoxifen (a drug FDA approved to treat breast cancer) increased erythropoietin production and decreased fibrosis. The authors therefore suggest that tamoxifen and related drugs could provide benefit to individuals with chronic kidney disease.

TITLE: Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... 2014 UHY LLP, a member of ... of UHY International Business – Issue 29. This bi-annual ... the most current business challenges and key issues faced ... covers the following topics:, , Key ... thrive over the next five years? Where are growth ...
(Date:7/28/2014)... Dawn Echols’ professional background spans ... music. This experience has honed her people skills ... Her professional counseling ( http://dawningphoenix.com ) work includes ... offenders in domestic violence. , As owner ... enjoys counseling individuals and groups for a variety ...
(Date:7/28/2014)... of a surgical procedure to treat severe chronic migraine ... percent of the time in patients treated at Massachusetts ... of Plastic and Reconstructive Surgery report that more than ... all of whom had headaches associated with compression ... year later. The team,s paper has received advance ...
(Date:7/28/2014)... Shofner Vision Center recently wrapped up ... LASIK and Cataract Surgeon, Dr. Stewart Shofner created ... public awareness for local not-for-profit organizations that help ... families. “This was our 2nd annual summer mission ... a variety of local not-for-profit organizations who are ...
(Date:7/28/2014)... Ticket Down is a dependable source for cheap ... the Sun Life Stadium in early September. The decades ... has is one that has continues to go on. With ... a consistent basis. The rivalry between South America nations, ... 2014 World Cup. To the delight of soccer aficionados ...
Breaking Medicine News(10 mins):Health News:Uhy International Business Issue 29 Now Available 2Health News:Uhy International Business Issue 29 Now Available 3Health News:Dawn M. Echols, M.S., LPC of Dawning Phoenix Speaks at Newly Formed Task Force 2Health News:Non-endoscopic migraine surgery provides significant symptom relief 2Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 2Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 3Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Showdown 2Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Showdown 3
... woke up as married men Sunday after a clutch ... weekend. ,The off-field antics of the so-called ... were as much the focus as their husbands and ... there was an almighty fixture pile-up for those celebrities, ...
... flu in more than a year has highlighted growing complacency ... the country, experts said Sunday . A 20-year-old man from ... H5N1 strain a week ago, the communist government said, and ... the virus since last month. ,The country's first ...
... born after embryo biopsy for preimplantation genetic diagnosis (PGD) ... born after artificial reproduction technologies (ART) without PGD. ... at risk of transmitting genetic diseases. Instead of carrying ... pregnancy, in vitro fertilisation (IVF) with intracytoplasmic sperm injection ...
... has found that waiting just two minutes to cut the ... boost as it reduces the risk of blood disorders . ... University in Hamilton, Canada, and involved more than 1,900 newborns. ... university, said that the results showed that as little as ...
... have identified potential chinks in the parasite that causes ... some 12 million people around the world . Their ... cases of leishmaniasis could be a boon for drug ... already slender. ,British-led scientists compared the genetic ...
... her parents and doctors in a perplex state when her weight ... to the normal baby growth chart Kaceys recordings were way beyond ... see her ballooning. I was scared, worried - because the weight ... it was like two, three pounds every week. And it was ...
Cached Medicine News:Health News:WAG Wedding Extravaganza for England Footballers 2Health News:Vietnam Bird Flu Death a Call for Action, Say Experts 2Health News:Vietnam Bird Flu Death a Call for Action, Say Experts 3Health News:Children Born After PGD as Healthy as Kids Born After ART 2Health News:2 Minute Delay in Cutting Cord can Give Babies a 'significant' Health Boost 2Health News:Gene Study Throws Up New Targets for Leishmaniasis 2Health News:Obese Infant Kacey Causes Concern 2
(Date:7/28/2014)... -- Anthera Pharmaceuticals, Inc. (NASDAQ: ANTH ), today ... ended June 30, 2014. Net loss for ... compared to $8.3 million for the same period in 2013. ... a decrease in interest expense in the current period.  ... 30, 2014 was $15.2 million, compared with net loss of ...
(Date:7/28/2014)... , July 28, 2014   Stone ... settlement of off-label marketing and fraud claims between ... Vascular Solutions, Inc. ("VSI").  The settlement covers fraud ... devices for endovenous laser ablation of varicose veins ... a firm with a history of representing whistleblowers ...
(Date:7/28/2014)... , July 28, 2014  Surgical Theater, LLC ... to its Business Advisory Board. New members include ... President for Business Development and New Technologies for ... , former Senior Vice President and General Manager ... Theater applies flight simulation technology to brain surgery ...
Breaking Medicine Technology:Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 2Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 3Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 4Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 5Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 6Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 7Stone & Magnanini LLP Announces $520,000 Department of Justice False Claims Act Settlement With Vascular Solutions, Inc. 2Stone & Magnanini LLP Announces $520,000 Department of Justice False Claims Act Settlement With Vascular Solutions, Inc. 3Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 2Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 3Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 4Surgical Theater Names Former Given Imaging Ltd. and Philips Healthcare Executives to Business Advisory Board 5
... OAKS, Calif., and COLLEGEVILLE, Pa., Nov. 6, 2010 Amgen ... PFE ) and world-class professional golfer Phil Mickelson, have ... diagnosis of psoriatic arthritis and treatment with Enbrel® (etanercept), and ... for proper assessment and care. "This partnership ...
... N.C., Nov. 5, 2010 Marketing strategies that engage ... particular therapeutic area are critical to launching a successful ... According to a recently released report from Best Practices, ... Successful Diabetes Product Launches" (click link to download a ...
Cached Medicine Technology:Amgen, Pfizer, and World-Class Professional Golfer Phil Mickelson Announce Partnership 2Amgen, Pfizer, and World-Class Professional Golfer Phil Mickelson Announce Partnership 3Amgen, Pfizer, and World-Class Professional Golfer Phil Mickelson Announce Partnership 4Amgen, Pfizer, and World-Class Professional Golfer Phil Mickelson Announce Partnership 5Amgen, Pfizer, and World-Class Professional Golfer Phil Mickelson Announce Partnership 6Diabetes Product Launch: Prepping the Market Through Thought Leader Outreach 2
The Total Toe System offers a new generation in first metatarsophalangeal joint reconstruction....
... part in our daily lives. But degenerative ... cause severe handicaps. A decisive consideration in ... to produce a reconstructed joint function that ... possible.,The cementless RM Finger System has proven ...
... hands play an important part in our ... and rheumatic changes can cause severe handicaps. ... the finger-joint prostheses was to produce a ... natural function as nearly possible.,The cementless RM ...
... SYSTEM for the Orthopedic Foot and Ankle ... be used for small bone osteotomies, fractures ... simplified screw sizes in one compact tray. ... set of instrumentation. These lag screws ...
Medicine Products: