Navigation Links
JCI online early table of contents: Sept. 12, 2011
Date:9/12/2011

on, Massachusetts, USA.
Phone: 617.724.8922; Fax: 617.726.5669; E-mail: ssever@partners.org.

Jochen Reiser
University of Miami, Miami, Florida, USA.
Phone: 305.243.2349; Fax: 305.243.2309; E-mail: jreiser@med.miami.edu.

View this article at: http://www.jci.org/articles/view/58552?key=b618f54191c2ab2d5ed1


NEPHROLOGY: Cells from outside the kidney link two features of chronic kidney disease

Individuals with chronic kidney disease often suffer from anemia. This is because the cells in the kidney that produce erythropoietin, the hormone that stimulates the production of new red blood cells in the bone marrow, are dysfunctional in these individuals. Dysfunction of these cells (fibroblasts) also causes scarring of the kidney, a condition known as renal fibrosis, which is a central feature of chronic kidney disease. Despite the importance of fibroblasts in chronic kidney disease, little is known about their origin and how they are regulated. Now, a team of researchers, led by Motoko Yanagita, at Kyoto University, Japan, has determined that the majority of erythropoietin-producing fibroblasts in the healthy mouse kidney are derived from cells that originally came from outside the kidney. Importantly, in the diseased kidney, these particular fibroblasts became dysfunctional, decreasing production of erythropoietin and contributing to fibrosis. Further, in a mouse model of renal fibrosis, treatment with tamoxifen (a drug FDA approved to treat breast cancer) increased erythropoietin production and decreased fibrosis. The authors therefore suggest that tamoxifen and related drugs could provide benefit to individuals with chronic kidney disease.

TITLE: Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. TheReliefPlace.com Launches Online Store “The Relief Shop” - What Does this Medical Supply Store Carry and How Can They Help You?
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. DavisPTnetwork Partners with the New York Physical Therapy Association to Provide Online Continuing Education
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. Pharmahelper Pleased To Recognize Online Pharmacy Practice Standards Announced By Google Adwords
6. Online Dating Reinvents Itself with the Recent Roll-Out of Teacherhookup.com, a Free Website that Focuses on a Person's Career in Education!
7. EdenHome.com Adds Aventura Organic Clothes to Site and Announces Largest Online Selection of Stylish Organic Clothes for Men, Women and Children
8. Fire Protection Online Resolves Safety Concerns with CO2 Fire Extinguishers
9. JCI online early table of contents: Feb. 15, 2010
10. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
11. New Online Store Makes Buying Cosmetics a Healthy Choice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... (PRWEB) January 22, 2015 The Incredible Bulk ... Ben Pakulski to increase lean muscle by up to 30lbs ... caught the attention of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative ... it is a step-by-step, scientific diet formula that allows the ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David ... Show to bestow a Juvent Sports Achievement award upon ... McKitrick. The award commemorated and congratulated McKitrick for her ... won her first amateur tournament in 1979 and most ...
(Date:1/22/2015)... Carinsurancesavings.biz has released a new blog post presenting the ... , Purchasing an accidental death and dismemberment rider for ... of rider provides benefits if the insured dies in an ... form of life insurance. , AD&D is not expensive ...
(Date:1/22/2015)... IsoComforter, Inc. has introduced the most innovative and ... to treat specific body parts and muscle groups. , ... to use patented cold therapy machine with the innovative IsoTube ... muscle injuries. IsoComforter has become the industry leader in ...
(Date:1/22/2015)... is a famous dress online store for wedding dresses and ... collection of wedding dresses , and launches a site-wide women’s ... dress on your big day; the wedding gown is the ... to find the most suitable wedding dress. Now, we are ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2
... fattest mice can overeat without developing insulin resistance or ... a dichotomy that helps explain why not all obese ... has found. , Consuming excess calories usually spurs insulin ... online today in the Journal of Clinical Investigation ...
... with difficulty reading actually respond better to female teachers, ... boys develop higher positive self-perceptions as readers when they ... male research assistants. , The study focused on 175 ... readers by their teachers. The boys participated in a ...
... reality, volunteers mimicked the near-death phenomenon , , THURSDAY, Aug. ... close to replicating the mysterious "out-of-body" experience that trauma ... results of two experiments on healthy volunteers, reported in ... what experts call a plausible neurological explanation for these ...
... Sahlgrenska Academy has established that surgery reduces premature death ... has shown that mortality is significantly lower among patients ... , The results are published today in The ... the first time that surgery against obesity not only ...
... costs increased 57% from 1999 to 2004, analysis shows , ... progress in the prevention and treatment of kidney failure in ... new analysis shows. , In 2004, the most recent year ... percent of the population) started dialysis or received a kidney ...
... gastric bypass, banding, experts say , , WEDNESDAY, Aug. 22 ... for years, two major studies find that weight-loss surgeries ... study of almost 16,000 obese people found long-term mortality ... bypass. And a Swedish study of more than 4,000 ...
Cached Medicine News:Health News:Despite overeating, morbidly obese mice gain protection against diabetes 2Health News:Experiments Get Close to 'Out-of-Body' Experience 2Health News:Experiments Get Close to 'Out-of-Body' Experience 3Health News:Experiments Get Close to 'Out-of-Body' Experience 4Health News:Surgery for severe obesity saves lives 2Health News:Expenses Overshadow Optimism for Kidney Failure Patients 2Health News:Weight-Loss Surgeries Extend Lives 2Health News:Weight-Loss Surgeries Extend Lives 3Health News:Weight-Loss Surgeries Extend Lives 4
(Date:1/23/2015)... Jan. 23, 2015  Today the U.S. Food and Drug ... the prevention of serogroup B meningococcal disease ... vaccine Trumenba®, which received FDA approval in October, represent ... disease. "I have heard over and ...
(Date:1/23/2015)... 23, 2015 Research and Markets ( http://www.researchandmarkets.com/research/5dh22x/urinary_catheters ... Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and ... Size, Share, Growth, Trends and Forecast 2014 - 2020" ... At present, the global market for urinary catheters is ...
(Date:1/23/2015)... BETHESDA, Md. , Jan. 23, 2015  Northwest Biotherapeutics, Inc. ... developing DCVax® personalized immune therapies for operable and inoperable solid ... will present at the 7 th Annual Phacilitate Immunotherapy ... NW Bio,s presentation at Phacilitate will take place on January ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3
... 2011 ChromaDex® Corp. (OTCBB: CDXC) today announced ... ChromaDex® the exclusive rights to a joint patent ... the method of inducing UDP-glucuronosyltransferase (UGT) activity using ... found in blueberries and demonstrated to have multiple ...
... Sept. 8, 2011 Abaxis, Inc. (NasdaqGS: ABAX), a ... today that Clint Serverson, chief executive officer,  will present ... Tuesday, September 13, 2011 at 10:20 a.m. ET at ... AbaxisAbaxis develops, manufactures, markets and sells portable blood analysis ...
Cached Medicine Technology:ChromaDex®'s Novel Ingredient pTeroPure® to be Studied as Potential Treatment for Fighting Skin Cancers 2ChromaDex®'s Novel Ingredient pTeroPure® to be Studied as Potential Treatment for Fighting Skin Cancers 3Abaxis to Present at 2011 Morgan Stanley Global Healthcare Unplugged Conference 2
... a high-throughput immunoassay system built around the ... with the important addition of Logic Driven ... be designed for optimal performance with the ... critical assays such as the cardiac biomarkers ...
... line of digital x-ray detectors from KUBTEC ... complete with 12 to 16 bit digital ... a photodiode array sensor with pixel spacing ... available in low x-ray energies (10-50 kV) ...
... The desk-top XCAT 50 X-Ray System from ... ability to provide two and three dimensional representation ... series provides volumetric reconstruction of specimen X-ray images, ... to provide high level of detail in standard ...
... provides the most current protocols ... urinary and fecal incontinence. It ... providing complete patient information for ... testimonials have proven Urostym™ to ...
Medicine Products: